Pediatric Drug Safety Signal Detection: A New Drug–Event Reference Set for Performance Testing of Data-Mining Methods and Systems

Osokogu, Osemeke U.; Fregonese, Federica; Ferrajolo, Carmen; Verhamme, Katia; de Bie, Sandra; Jong, Geert ’t; Catapano, Mariana; Weibel, Daniel; Kaguelidou, Florentia; Bramer, Wichor M.; Hsia, Yingfen; Wong, Ian C. K.; Gazarian, Madlen; Bonhoeffer, Jan; Sturkenboom, Miriam

doi:10.1007/s40264-015-0265-0

Pediatric Drug Safety Signal Detection: A New Drug–Event Reference Set for Performance Testing of Data-Mining Methods and Systems

BackgroundBetter evidence regarding drug safety in the pediatric population might be generated from existing data sources such as spontaneous reporting systems and electronic healthcare records. The Global Research in Paediatrics (GRiP)–Network of Excellence aims to develop pediatric-specific met…