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Cited by 12

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

The Frequency of Drug-Induced Liver Injury Due to Antibiotics Among Hospitalised Patients

Björnsson, Robert A, Sigurdsson, Sigurdur Sölvi, Arnarson, Dagur Tjörvi, Logason, Egill, Björnsson, Einar Stefan·2025·Drug Safety
DOI 10.1007/s40264-025-01541-w
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Abstract

Introduction Most epidemiological studies have found antibiotics to be the most common cause of drug-induced liver injury (DILI). It is unclear what the risk of DILI is associated with different antibiotics. Objective The aim of the study was to assess the frequency of DILI due to the most commonly used antibiotics among inpatients, in a population-based setting. Methods Patients who were treated with the 14 most-used antibiotics at Landspitali University Hospital Iceland 2012-2023, with concomitant: > 5 × upper limit of normal (ULN) of alanine aminotransferase (ALT) and/or > 2 × ULN of alkaline phosphatase (ALP), were identified. If DILI was a potential cause, the Revised Electronic Causality Assessment Method (RECAM) method was used to determine likelihood of DILI. Results Overall 2292 patients fulfilled the inclusion criteria, 52 of whom were found to have DILI, median age 67 (range 21-93) years, 58% females, 17 (33%) with jaundice and three (5.8%) died of liver failure. The most commonly implicated agent was amoxicillin/clavulanate (n = 23) in 1:1327 users (0.075%), ceftriaxone (n = 8) 1:3779 (0.02%), cefazolin (n = 7) 1: 6363 (0.016%), cloxacillin 1:6024 (n = 4) (0.017%), piperacillin/tazobactam (n = 2) 1:1551 (0.097%), vancomycin (n = 2) 1:1966 (0.076%), trimethoprim-sulfamethoxazole (TMP/SMX) (n = 3) 1:1096 (0.091%) and ciprofloxacin (n = 1) 1:10,938 (0.009%). In two cases, more than one antibiotic was considered likely. Conclusions Drug-induced liver injury was found…

Overview

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Crossref · 10.1007/s40264-025-01541-w

Cites

27 of 27 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 2

  1. https://www.ncbi.nlm.nih.gov/books/NBK547852/
  2. deLemos AS, Ghabril M, Rockey DC, Gu J, Barnhart H, Fontana RJ, et al. Amoxicillin-clavulanate-induced liver injury. Dig Dis Sci. 2016;61:2406–16. · DOI

Cited by

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Metadata

Authors
Björnsson, R. A., Sigurdsson, S. S., Arnarson, D. T., Logason, E., & Björnsson, E. S.
ORCID
Björnsson, Einar Stefan
Venue
Drug Safety
Publisher
Springer Science and Business Media LLC
Published
2025-03-12
Volume
48
Issue
7
Pages
795-804
ISSN
  • 0114-5916
  • 1179-1942
DOI
10.1007/s40264-025-01541-w
Cited by
12
References
27
Language
en
Licence

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.