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Drug‐induced liver injury in a Swedish University hospital out‐patient hepatology clinic
Abstract
Summary: Background: Limited data exist on the proportion of drug‐induced liver injury among out‐patients seen in a hepatology clinic. Aim: To determine the proportion of drug‐induced liver injury cases, and identify the most important agents and the nature of the liver injury. Methods: A computerized diagnoses database in an out‐patient hepatology clinic in a Swedish University hospital was analysed during the period 1995–2005. All suspected drug‐induced liver injury cases were causality assessed with the International Consensus Criteria. Results: A total of 1164 cases were seen for the first time during this period. Drug‐induced liver injury with at least a possible causal relationship was found in 77 cases (6.6%), 38 (3.3%) of whom were referred for evaluation to the out‐patient clinic whereas 3% had a follow‐up after hospitalization of drug‐induced liver injury. The median age was 58 years, 43 (56%) were females, a hepatocellular pattern was observed in 37 cases (48%), cholestatic in 31 (40%) and mixed in 12%. Antibiotics were the most common agents causing drug‐induced liver injury followed by non‐steroidal anti‐inflammatory drugs, with diclofenac most often responsible for the drug‐induced liver injury. Conclusions: Drug‐induced liver injury cases constituted 6% of all out‐patients and 3% of referrals and occurred more often in women. Antibiotics and diclofenac were the most common causes of drug‐induced liver injury among out‐patients.
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Females are suggested to have a higher risk of idiosyncratic DILI than males in many retrospective studies.
“Though females are suggested to have a higher risk of idiosyncratic DILI than males in many retrospective studies, 8,[27][28][29][30]”
From Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019) · cites this paper as [29]
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Metadata
- Authors
- DE VALLE, M. B., AV KLINTEBERG, V., ALEM, N., OLSSON, R., & BJÖRNSSON, E.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2006-09-20
- Volume
- 24
- Issue
- 8
- Pages
- 1187-1195
- ISSN
- 0269-2813
- 1365-2036
- Cited by
- 179
- References
- 0
- Language
- en
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