Cited by 179

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Drug‐induced liver injury in a Swedish University hospital out‐patient hepatology clinic

DE VALLE, M. B., AV KLINTEBERG, V., ALEM, N., OLSSON, R., BJÖRNSSON, E.·2006·Alimentary Pharmacology & Therapeutics

Abstract

Summary: Background: Limited data exist on the proportion of drug‐induced liver injury among out‐patients seen in a hepatology clinic. Aim: To determine the proportion of drug‐induced liver injury cases, and identify the most important agents and the nature of the liver injury. Methods: A computerized diagnoses database in an out‐patient hepatology clinic in a Swedish University hospital was analysed during the period 1995–2005. All suspected drug‐induced liver injury cases were causality assessed with the International Consensus Criteria. Results: A total of 1164 cases were seen for the first time during this period. Drug‐induced liver injury with at least a possible causal relationship was found in 77 cases (6.6%), 38 (3.3%) of whom were referred for evaluation to the out‐patient clinic whereas 3% had a follow‐up after hospitalization of drug‐induced liver injury. The median age was 58 years, 43 (56%) were females, a hepatocellular pattern was observed in 37 cases (48%), cholestatic in 31 (40%) and mixed in 12%. Antibiotics were the most common agents causing drug‐induced liver injury followed by non‐steroidal anti‐inflammatory drugs, with diclofenac most often responsible for the drug‐induced liver injury. Conclusions: Drug‐induced liver injury cases constituted 6% of all out‐patients and 3% of referrals and occurred more often in women. Antibiotics and diclofenac were the most common causes of drug‐induced liver injury among out‐patients.

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Crossref · 10.1111/j.1365-2036.2006.03117.x

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  • Females are suggested to have a higher risk of idiosyncratic DILI than males in many retrospective studies.

    “Though females are suggested to have a higher risk of idiosyncratic DILI than males in many retrospective studies, 8,[27][28][29][30]”

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Metadata

Authors
DE VALLE, M. B., AV KLINTEBERG, V., ALEM, N., OLSSON, R., & BJÖRNSSON, E.
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2006-09-20
Volume
24
Issue
8
Pages
1187-1195
ISSN
  • 0269-2813
  • 1365-2036
Cited by
179
References
0
Language
en

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