Cited by 127Epigenetics and DNA MethylationGenetic Associations and EpidemiologyHealth, Environment, Cognitive Aging

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Epigenetic Research in Neuropsychiatric Disorders: the “Tissue Issue”

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Bakulski, Kelly M., Halladay, Alycia, Hu, Valerie W., Mill, Jonathan, Fallin, M. Daniele·2016·Current Behavioral Neuroscience Reports

DOI 10.1007/s40473-016-0083-4PMC PMC5235359

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Abstract

Purpose of review Evidence has linked neuropsychiatric disorders with epigenetic marks as either a biomarker of disease, biomarker of exposure, or mechanism of disease processes. Neuropsychiatric epidemiologic studies using either target brain tissue or surrogate blood tissue each have methodological challenges and distinct advantages.Recent findings Brain tissue studies are challenged by small sample sizes of cases and controls, incomplete phenotyping, post-mortem timing, and cellular heterogeneity, but the use of a primary disease relevant tissue is critical. Blood-based studies have access to much larger sample sizes and more replication opportunities, as well as the potential for longitudinal measurements, both prior to onset and during the course of treatments. Yet, blood studies also are challenged by cell-type heterogeneity, and many question the validity of using peripheral tissues as a brain biomarker. Emerging evidence suggests that these limitations to blood-based epigenetic studies are surmountable, but confirmation in target tissue remains important.Summary Epigenetic mechanisms have the potential to help elucidate biology connecting experiential risk factors with neuropsychiatric disease manifestation. Cross-tissue studies as well as advanced epidemiologic methods should be employed to more effectively conduct neuropsychiatric epigenetic research.

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Authors: Bakulski, K. M., Halladay, A., Hu, V. W., Mill, J., & Fallin, M. D.
Affiliations: University of Michigan (US)
Rutgers, The State University of New Jersey (US)
George Washington University (US)
King's College London (GB)
Johns Hopkins University (US)
Corresponding author: Fallin, M. Daniele
ORCID: Bakulski, Kelly M.
Halladay, Alycia
Hu, Valerie W.
Mill, Jonathan
Fallin, M. Daniele
Venue: Current Behavioral Neuroscience Reports
Publisher: Springer Science and Business Media LLC
Published: 2016-08-02
Volume: 3
Issue: 3
Pages: 264-274
ISSN: 2196-2979 (ISSN-L)
DOI: 10.1007/s40473-016-0083-4
PMC: PMC5235359
OpenAlex: W2505166506
Cited by: 127
References: 111
Citations by year: 2026: 5 · 2025: 7 · 2024: 12 · 2023: 13 · 2022: 25 · 2021: 13 · 2020: 15 · 2019: 11 · 2018: 14 · 2017: 12
FWCI: 6.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Current Behavioral Neuroscience Reports (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (ES017646, ES023061)
Medical Research Council (MRC; MR/K013807/1)
National Institutes of Health (AG036039)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: epigenetics, neuropsychiatric disorders, blood-based biomarkers, brain tissue, surrogate tissue, cellular heterogeneity, postmortem brain, risk factors

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