Epigenetics: A landscape takes shape
Open accessAbstract
Epigenetics has recently evolved from a collection of diverse phenomena to a defined and far-reaching field of study. In this Essay, we examine the epistemology of epigenetics, provide a brief overview of underlying molecular mechanisms, and suggest future challenges for the field.
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The epigenetic landscape is a platform for interaction of a variety of environmental factors with a complex genetic environment to change gene expression.
“the term epigenetic landscape is defined as a platform for the interaction of a variety of environmental factors with a complex genetic environment to change the expression of genes [29,30,31].”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [29]
The paper’s Abstract links changes in the “epigenetic landscape” to distinct, stable patterns of gene expression. It does not define that landscape as a platform where environmental factors interact with a complex genetic environment, so that part of the attributed definition is unsupported. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe generally accepted concept of epigenetics specifies mitotically and/or meiotically heritance and one that does not entail a change in genomic DNA.
“the generally accepted concept has obtained a more accurate definition as specifying mitotically and/or meiotically heritance and one that does not entail a change in genomic DNA.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [29]
The definition passage (section labeled Abstract; page unavailable) supports the claim that epigenetic changes do not alter the underlying DNA sequence. It describes those changes as potentially stable and *ideally* heritable, however, rather than requiring mitotic or meiotic inheritance as the citing sentence states. (LLM, conf=0.88)
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- Authors
- Goldberg, A. D., Allis, C. D., & Bernstein, E.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Allis, C. David
- Bernstein, Emily
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 128
- Issue
- 4
- Pages
- 635-638
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2130907138
- Cited by
- 2,466
- References
- 2
- Citations by year
- 2026: 63 · 2025: 89 · 2024: 116 · 2023: 151 · 2022: 147 · 2021: 170 · 2020: 147 · 2019: 159 · 2018: 150 · 2017: 166 · 2016: 163 · 2015: 148 · 2014: 150 · 2013: 127 · 2012: 129
- FWCI
- 36.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM 07739, T32GM007739)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenetics, history of epigenetics
- MeSH terms
- Animals, Cell Differentiation, Cell Division, Gene Expression Regulation, Histones, Humans, DNA Methylation, RNA, Untranslated, Chromatin Assembly and Disassembly, Epigenesis, Genetic
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