The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Selenium, aging and aging-related diseases
Abstract
Selenium is an essential trace element in the human body and plays an important role in the body via selenoprotein, which contains selenium. Selenoproteins (glutathione peroxidase, thioredoxin reductase, methionine sulfoxide reductase1 and endoplasmic reticulum-selenoproteins, etc.) have antioxidant effects and are involved in regulating antioxidant activities. Aging is an inevitable process and is always accompanied by aging-related diseases. Reactive oxygen species are important initial factors in aging and aging-related diseases. Selenium contributes to the alleviation of reduced reactive oxygen species-mediated inflammation, reduced DNA damage and prolonged telomere length and thereby plays roles in fighting aging and preventing aging-related diseases. In the elderly, aging-related diseases include neuropsychiatric diseases, tumors, cardiovascular diseases, and skin aging, among others. Selenium supplementation is an important strategy for anti-aging and the prevention of aging-related diseases and is of great significance for the elderly. However, with the accumulation of related research, selenium supplementation does not necessarily contribute to the prevention of aging and aging-related diseases. It is believed that a low level of selenium is beneficial to the human body. Thus, the effect of selenium on human aging and aging-related diseases is still controversial. This paper reviews the research progress and objective role of selenium in aging and aging-related diseases.
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In the citing paper
“Selenium supplementation is an important strategy for inhibiting wrinkles, because it can reverse ultraviolet light damage and play an anti-ageing role in the skin [89,92].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [89]
In the citing paper
“Selenium exhibits strong antioxidant properties and protects against DNA damage [88,89].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [89]
In the citing paper
“The mineral is also important for skin function, having a protective effect and the ability to scavenge free radicals [89].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [89]
Citations
Cites
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Regulation of Selenium Metabolism and Transport
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Cited by
Sorted by citations
Selenium–Fascinating Microelement, Properties and Sources in Food
Kieliszek, M. (2019) · Molecules · doi:10.3390/molecules24071298 · Cited by 631
Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345
“Selenium supplementation is an important strategy for inhibiting wrinkles, because it can reverse ultraviolet light damage and play an anti-ageing role in the skin [89,92].”
BackgroundSelenium: An Antioxidant with a Critical Role in Anti-Aging
Bjørklund, G., Shanaida, M., Lysiuk, R., Antonyak, H., Klishch, I. M., Shanaida, V., & Peana, M. (2022) · Molecules · doi:10.3390/molecules27196613 · Cited by 264
Natural Compounds and Products from an Anti-Aging Perspective
Bjørklund, G., Shanaida, M., Lysiuk, R., Butnariu, M., Peana, M., Sărac, I., Strus, O., Smetanina, K., & Chirumbolo, S. (2022) · Molecules · doi:10.3390/molecules27207084 · Cited by 234
Selenium supplementation in the prevention of coronavirus infections (COVID-19)
Kieliszek, M., & Lipinski, B. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109878 · Cited by 182
Metadata
- Authors
- Cai, Z., Zhang, J., & Li, H.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Li, Hongjun
- Venue
- Aging Clinical and Experimental Research
- Published
- 2018-12-03
- Volume
- 31
- Issue
- 8
- Pages
- 1035-1047
- ISSN
- 1594-0667 (ISSN-L)
- 1720-8319
- OpenAlex
- W2902968311
- Cited by
- 150
- References
- 134
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 28 · 2023: 25 · 2022: 32 · 2021: 18 · 2020: 16 · 2019: 9
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Aging Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- selenium, aging, age-related diseases, selenoproteins, glutathione peroxidase, thioredoxin reductase, methionine sulfoxide reductase, reactive oxygen species, antioxidant activity, telomere length, DNA damage, inflammation, selenium supplementation, skin aging, cardiovascular disease, cancer prevention, neuropsychiatric disorders
- MeSH terms
- Aging, Animals, DNA Damage, Glutathione Peroxidase, Humans, Selenium, Reactive Oxygen Species
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