New Biomarkers in Anaphylaxis (Beyond Tryptase)
Open accessAbstract
Purpose of review The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying mechanisms, effector cells, and the potential biomarkers involved depending on the anaphylaxis endotypes.Recent findings New insight into the potential relevance of pathways others than IgE-dependent anaphylaxis has been unraveled, as well as other biomarkers than tryptase, such as the role of platelet activation factor, basogranulin, dipeptidyl peptidase I, CCL-2, and other cytokines.Summary Gaining knowledge of all the mediators and cellular activation/communication pathways involved in each endotype of anaphylaxis will allow the application of precision medicine in patients with anaphylactic reactions, providing insights to the most appropriate approach in each case and helping to stratify severity and risk prediction.
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Other mediators such as platelet-activating factor (PAF), prostaglandin D2, leukotriene E4, histamine, or other cytokines might be more sensitive in patients with food-induced anaphylaxis.
“It is possible that other mediators such as platelet-activating factor (PAF), prostaglandin D2, leukotriene E4, histamine, or other cytokines might be more sensitive in these patients [34,35,36,37].”
From Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders (2023) · cites this paper as [37]
The Tryptase section says tryptase may not rise in food-induced anaphylaxis, and the PAF, prostaglandin, leukotriene, and cytokine sections discuss other potential biomarkers. The paper does not establish that the listed mediators are more sensitive specifically in food-induced anaphylaxis; its Histamine section also cautions that histamine is not a good diagnostic biomarker in daily practice because of its short half-life. Page numbers were not available in our copy. (LLM, conf=0.84)
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Flagged first, then by citations
Research works printed but not linked: 2
- [24]Kabashima K Nakashima C Nonomura Y Otsuka A Cardamone C Parente R Biomarkers for evaluation of mast cell and basophil activation Immunol Rev 2018 282 1 114 120 10.1111/imr.12639 29431209 · DOI
- Passia E Jandus P Using baseline and peak serum tryptase levels to diagnose anaphylaxis: a review Clin Rev Allergy Immunol 2020 58 3 366 76 10.1007/s12016-020-08777-7 32034676 · DOI
Cited by
Sorted by citations
Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders
Beyens, M., Toscano, A., Ebo, D., Gülen, T., & Sabato, V. (2023) · Diagnostics · doi:10.3390/diagnostics13243662 · Cited by 22 · see citing works
- Authors
- Galvan-Blasco, P., Gil-Serrano, J., & Sala-Cunill, A.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Sala-Cunill, A.
- Venue
- Current Treatment Options in Allergy
- Published
- 2022-11-28
- Volume
- 9
- Issue
- 4
- Pages
- 303-322
- ISSN
- 2196-3053 (ISSN-L)
- PMC
- PMC9702867
- OpenAlex
- W4310117095
- Cited by
- 19
- References
- 88
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 5
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Treatment Options in Allergy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- anaphylaxis, biomarkers, tryptase, platelet activation factor, dipeptidyl peptidase I, MCP-1, cytokines, precision medicine, risk stratification
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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