Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis
Abstract
Background Platelet-activating factor (PAF) is an important mediator and correlates with anaphylaxis severity. How well PAF correlates with severity relative to histamine or tryptase is not known.Objective To analyze the levels of PAF, histamine, and tryptase as a function of severity in patients with acute allergic reactions.Methods PAF, histamine, and tryptase levels were measured in blood samples collected from 23 healthy volunteers and from 41 patients during acute allergic reactions. Reactions were stratified by severity from grade 1 (least severe) to grade 3 (most severe).Results Among the 3 reaction grades, there were significant differences by ANOVA for PAF (P < .0001). The proportion of elevated PAF values increased across severity groups (P = .0009). Increased PAF levels were observed in 20%, 66.7%, and 100% of the patients with grades 1, 2, and 3 allergic reactions, respectively. While the proportion of elevated histamine values increased from 40% to 57% to 70% across grades 1, 2, and 3, respectively, these were not significantly different (P = .40). For tryptase, the proportion of elevated values increased monotonically from 0 in grade 1 to 4.8% in grade 2 to 60% in grade 3 (P = .0002).Conclusions The PAF level was significantly elevated in proportion to the severity of acute allergic reactions. Whereas the PAF level was elevated in all patients with severe anaphylaxis, this was not true for either histamine or tryptase. Neither histamine nor tryptase showed as good correlations with severity scores as did PAF. These data are consistent with a pivotal role for PAF as a mediator of anaphylaxis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There are insufficient data to demonstrate the clinical utility of heparin, serotonin, neuropeptides, platelet-activating factor, and chromogranin A in the diagnosis of MCA and MCAS.
“However, there are insuf fi cient data to demonstrate their clinical utility in the diagnosis of MCA and MCAS.”
From Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review (2021) · cites this paper as [73]
Cites
Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis
Vadas, P., Gold, M., Perelman, B., Liss, G. M., Lack, G., Blyth, T., Simons, F. E. R., Simons, K. J., Cass, D., & Yeung, J. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070030 · Cited by 526 · see citing works
Self-citationLieberman, P., Camargo, C. A., Bohlke, K., Jick, H., Miller, R. L., Sheikh, A., & Simons, F. E. R. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61086-1 · Cited by 480 · see citing works
Anaphylaxis: Lessons from mouse models
Finkelman, F. D. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.033 · Cited by 443 · see citing works
Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis
Smart, B. A. (2008) · PEDIATRICS · doi:10.1542/peds.2008-2139jj · Cited by 396 · see citing works
Role of Platelet-Activating Factor in Cardiovascular Pathophysiology
Montrucchio, G., Alloatti, G., & Camussi, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1669 · Cited by 372 · see citing works
Emergency department anaphylaxis: A review of 142 patients in a single year
Brown, A. F., McKinnon, D., & Chu, K. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.119028 · Cited by 371 · see citing works
Anaphylaxis: can we tell who is at risk of a fatal reaction?
Pumphrey, R. S. H. (2004) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/01.all.0000136762.89313.0b · Cited by 320 · see citing works
Anaphylaxis: a review of 601 cases
Webb, L. M., & Lieberman, P. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61367-1 · Cited by 287 · see citing works
Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W.-H., Kume, K., Fukuchi, Y., Ikuta, K., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.11.1779 · Cited by 281 · see citing works
Lin, R. Y., Schwartz, L. B., Curry, A., Pesola, G. R., Knight, R. J., Lee, H.-S., Bakalchuk, L., Tenenbaum, C., & Westfal, R. E. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.107600 · Cited by 277 · see citing works
Platelet-Activating Factor, a Pleiotrophic Mediator of Physiological and Pathological Processes
Stafforini, D. M., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/714037693 · Cited by 234 · see citing works
Anaphylaxis, killer allergy: Long-term management in the community
Simons, F. E. R. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.002 · Cited by 224 · see citing works
Molecular mechanisms of anaphylaxis: Lessons from studies with murine models
Finkelman, F. D., Rothenberg, M. E., Brandt, E. B., Morris, S. C., & Strait, R. T. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.12.1125 · Cited by 211 · see citing works
Biochemical Markers of Anaphylactoid Reactions to Drugs Comparison of Plasma Histamine and Tryptase
Laroche, D., Vergnaud, M.-C., Sillard, B., Soufarapis, H., & Bricard, H. (1991) · Anesthesiology · doi:10.1097/00000542-199112000-00004 · Cited by 190 · see citing works
Allergy and the cardiovascular system
Triggiani, M., Patella, V., Staiano, R. I., Granata, F., & Marone, G. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03714.x · Cited by 179 · see citing works
Stone, S. F., Cotterell, C. L., Isbister, G. K., Holdgate, A., & Brown, S. G. A. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.055 · Cited by 151 · see citing works
Can serum mast cell tryptase help diagnose anaphylaxis?
Brown, S. G. A., Blackman, K. E., & Heddle, R. J. (2004) · Emergency Medicine Australasia · doi:10.1111/j.1742-6723.2004.00562.x · Cited by 137 · see citing works
Anaphylactic shock depends on PI3K and eNOS-derived NO
Cauwels, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25426 · Cited by 134 · see citing works
Arias, K., Baig, M., Colangelo, M., Chu, D. K., Walker, T. D., Goncharova, S. I., Coyle, A. J., Vadas, P., Waserman, S., & Jordana, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.012 · Cited by 114 · see citing works
Self-citationMast cells and basophils: friends as well as foes in bronchial asthma?
Marone, G., Triggiani, M., & de Paulis, A. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.10.010 · Cited by 108 · see citing works
Sarchielli, P., Alberti, A., Coppola, F., Baldi, A., Gallai, B., Floridi, A., Floridi, A., Capocchi, G., & Gallai, V. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2003.00717.x · Cited by 70 · see citing works
Effector Cells of Anaphylaxis: Mast Cells and Basophils
Schwartz, L. B. (2004) · Novartis Foundation symposium · doi:10.1002/0470861193.ch6 · Cited by 52 · see citing works
Serum tryptase levels in adverse drug reactions
Ordoqui, E., Zubeldia, J. M., Aranzábal, A., Rubio, M. F., Herrero, T., Tornero, P., Rodríguez, V. M., Prieto, A., & Baeza, M. L. (1997) · Allergy · doi:10.1111/j.1398-9995.1997.tb00182.x · Cited by 47 · see citing works
Fukuda, Y., Kawashima, H., Saito, K., Inomata, N., Matsui, M., & Nakanishi, T. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00920-6 · Cited by 46 · see citing works
Lie, W. J., Homburg, C., Kuijpers, T. W., Knol, E. F., Mul, E. P. J., Roos, D., & Tool, A. T. J. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01726.x · Cited by 35 · see citing works
Ohtsuka, T., Matsumaru, S., Uchida, K., Onobori, M., Matsumoto, T., 桑畑, 圭., & Arita, M. (1993) · PubMed · Cited by 28 · see citing works
Role for Basophils in Systemic Anaphylaxis
Karasuyama, H., Tsujimura, Y., Obata‐Ninomiya, K., & Mukai, K. (2010) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000315939 · Cited by 24 · see citing works
Cytokine Enhancement of Anaphylaxis
Strait, R. T., Morris, S. C., & Finkelman, F. D. (2004) · Novartis Foundation symposium · doi:10.1002/0470861193.ch7 · Cited by 23 · see citing works
Okunuki, H., Teshima, R., SAKUSHIMA, J.-I., Akiyama, H., Goda, Y., TOYODA, M., & Sawada, J. (2000) · Immunology Letters · doi:10.1016/s0165-2478(00)00264-9 · Cited by 18 · see citing works
PAF acetylhydrolase deficiency predisposes to fatal anaphylaxis
Vadas, P., Gold, M., Liss, G. M., Smith, C., Yeung, J., & Perelman, B. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(03)80712-1 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Shaker, M. S., Wallace, D. V., Golden, D. B. K., Oppenheimer, J. J., Bernstein, J. A., Campbell, R. L., Dinakar, C., Ellis, A. K., Greenhawt, M., Khan, D. A., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.01.017 · Cited by 744 · see citing works
The pathophysiology of anaphylaxis
Reber, L. L., Hernandez, J. D., & Galli, S. J. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.06.003 · Cited by 518 · see citing works
International consensus on (ICON) anaphylaxis
Simons, F. E. R., Ardusso, L., Bilò, M. B., Cardona, V., Ebisawa, M., El‐Gamal, Y., Lieberman, P., Lockey, R. F., Muraro, A. M., Roberts, G. C., et al. (2014) · World Allergy Organization Journal · doi:10.1186/1939-4551-7-9 · Cited by 489 · see citing works
Anaphylaxis—a practice parameter update 2015
Lieberman, P., Nicklas, R. A., Randolph, C., Oppenheimer, J., Bernstein, D., Bernstein, J., Ellis, A., Golden, D. B. K., Greenberger, P., Kemp, S., et al. (2015) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2015.07.019 · Cited by 474 · see citing works
Tordesillas, L., Berin, M. C., & Sampson, H. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.004 · Cited by 341 · see citing works
Human IgE-independent systemic anaphylaxis
Finkelman, F. D., Khodoun, M. V., & Strait, R. T. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.015 · Cited by 299 · see citing works
Anaphylaxis: Clinical patterns, mediator release, and severity
Brown, S. G. A., Stone, S. F., Fatovich, D. M., Burrows, S., Holdgate, A., Celenza, A., Coulson, A., Hartnett, L., Nagree, Y., Cotterell, C. L., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.06.015 · Cited by 277 · see citing works
World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base
Simons, F. E. R., Ardusso, L. R. F., Dimov, V., Ebisawa, M., El-Gamal, Y. M., Lockey, R. F., Sanchez-Borges, M., Senna, G. E., Sheikh, A., Thong, B. Y., et al. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000354543 · Cited by 269 · see citing works
Guideline for acute therapy and management of anaphylaxis
Ring, J., Beyer, K., Biedermann, T., Bircher, A. J., Duda, D., Fischer, J., Friedrichs, F., Fuchs, T., Gieler, U., Jakob, T., et al. (2014) · Allergo Journal International · doi:10.1007/s40629-014-0009-1 · Cited by 222 · see citing works
Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome
Valent, P., Akin, C., Bonadonna, P., Hartmann, K., Brockow, K., Niedoszytko, M., Nedoszytko, B., Siebenhaar, F., Sperr, W. R., Oude Elberink, J. N. G., et al. (2019) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2019.01.006 · Cited by 220 · see citing works
“Other potentially relevant mediators associated with activation of MC are platelet activating factor (PAF), tryptases and various cytokines (20,31,33-36) (Table 4).”
BackgroundAn IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis
Jönsson, F., de Chaisemartin, L., Granger, V., Gouél‐Cheron, A., Gillis, C. M., Zhu, Q., Dib, F., Nicaise‐Roland, P., Ganneau, C., Hurtado-Nédelec, M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat1479 · Cited by 169 · see citing works
Nguyen, S. M. T., Rupprecht, C. P., Haque, A., Pattanaik, D., Yusin, J. S., & Krishnaswamy, G. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157785 · Cited by 176 · see citing works
Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update
Ring, J., Beyer, K., Biedermann, T., Bircher, A. J., Fischer, M. J., Fuchs, T., Heller, A. R., Hoffmann, F., Huttegger, I., Jakob, T., et al. (2021) · Allergo Journal International · doi:10.1007/s40629-020-00158-y · Cited by 161 · see citing works
Human mast cell tryptase in biology and medicine
Vitte, J. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2014.04.001 · Cited by 152 · see citing works
Lordan, R., Tsoupras, A., Zabetakis, I., & Demopoulos, C. (2019) · Molecules · doi:10.3390/molecules24234414 · Cited by 137 · see citing works
Potential effector and immunoregulatory functions of mast cells in mucosal immunity
Reber, L. L., Sibilano, R., Mukai, K., & Galli, S. J. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.131 · Cited by 142 · see citing works
Mucosal Immunology of Food Allergy
Berin, M. C., & Sampson, H. A. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.043 · Cited by 144 · see citing works
Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives
Beck, S. C., Wilding, T., Buka, R. J., Baretto, R. L., Huissoon, A. P., & Krishna, M. T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00494 · Cited by 133 · see citing works
Do Corticosteroids Prevent Biphasic Anaphylaxis?
Alqurashi, W., & Ellis, A. K. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.05.022 · Cited by 122 · see citing works
Biomarkers for evaluation of mast cell and basophil activation
Kabashima, K., Nakashima, C., Nonomura, Y., Otsuka, A., Cardamone, C., Parente, R., Feo, G. D., & Triggiani, M. (2018) · Immunological Reviews · doi:10.1111/imr.12639 · Cited by 122 · see citing works
Food allergy: an enigmatic epidemic
Berin, M. C., & Sampson, H. A. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.04.003 · Cited by 117 · see citing works
Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis
Alqurashi, W., Stiell, I. G., Chan, K. J., Neto, G. M., Alsadoon, A., & Wells, G. A. (2015) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2015.05.013 · Cited by 101 · see citing works
A new framework for the interpretation of IgE sensitization tests
Roberts, G., Ollert, M., Aalberse, R., Austin, M., Custovic, A., DunnGalvin, A., Eigenmann, P. A., Fassio, F., Grattan, C., Hellings, P., et al. (2016) · Allergy · doi:10.1111/all.12939 · Cited by 98 · see citing works
Tryptase levels in children presenting with anaphylaxis: Temporal trends and associated factors
De Schryver, S., Halbrich, M., Clarke, A., La Vieille, S., Eisman, H., Alizadehfar, R., Joseph, L., Morris, J., & Ben-Shoshan, M. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.09.001 · Cited by 96 · see citing works
Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets
Schauberger, E. M., Peinhaupt, M., Cazares, T. A., & Lindsley, A. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0628-3 · Cited by 89 · see citing works
Platelet activating factor in allergies
Pałgan, K., & Bartuzi, Z. (2015) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632015600598 · Cited by 88 · see citing works
Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis
Korošec, P., Turner, P., Šilar, M., Kopač, P., Košnik, M., Gibbs, B. F., Shamji, M. H., Čustović, A., & Rijavec, M. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.12.989 · Cited by 86 · see citing works
Management of Food Allergies and Food-Related Anaphylaxis
Iglesia, E. G. A., Kwan, M., Virkud, Y. V., & Iweala, O. I. (2024) · JAMA · doi:10.1001/jama.2023.26857 · Cited by 85 · see citing works
Platelet Activating Factor Contributes to Vascular Leak in Acute Dengue Infection
Jeewandara, C., Gomes, L., Wickramasinghe, N., Gutowska‐Owsiak, D., Waithe, D., Paranavitane, S. A., Shyamali, N. L. A., Ogg, G. S., & Malavige, G. N. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003459 · Cited by 85 · see citing works
Gülen, T., Akin, C., Bonadonna, P., Siebenhaar, F., Broesby-Olsen, S., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, H. N. G., Butterfield, J. H., et al. (2021) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2021.06.011 · Cited by 83 · see citing works
“Other potential markers that have been discussed in the context of MCA include heparin, serotonin, neuropeptides, platelet-activating factor, and chromogranin A (CgA).(13,71-76) However, there are insufficient data to demonstrate their clinical utility in the diagnosis of MCA and MCAS.”
BackgroundThe rise of food allergy: Environmental factors and emerging treatments
Benedé, S., Blázquez, A.-B., Chiang, D. S., Tordesillas, L., & Berin, M. C. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.04.012 · Cited by 84 · see citing works
Mechanisms of human drug-induced anaphylaxis
Bruhns, P., & Chollet‐Martin, S. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.02.013 · Cited by 76 · see citing works
Risk multipliers for severe food anaphylaxis
Smith, P. K., Hourihane, J. O., & Lieberman, P. (2015) · World Allergy Organization Journal · doi:10.1186/s40413-015-0081-0 · Cited by 73 · see citing works
IgG1+ B‐cell immunity predates IgE responses in epicutaneous sensitization to foods
Jiménez‐Saiz, R., Ellenbogen, Y., Koenig, J. F. E., Gordon, M. E., Walker, T. D., Rosace, D., Spill, P., Bruton, K. M., Kong, J., Monteiro, K., et al. (2018) · Allergy · doi:10.1111/all.13481 · Cited by 68 · see citing works
Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice
Gillis, C. M., Jönsson, F., Mancardi, D. A., Tu, N., Beutier, H., van Rooijen, N., Macdonald, L. E., Murphy, A. J., & Bruhns, P. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.058 · Cited by 69 · see citing works
Dua, S., Dowey, J., Foley, L., Islam, S., King, Y., Ewan, P., & Clark, A. T. (2018) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2018.01.006 · Cited by 67 · see citing works
Targeting mast cells in inflammatory diseases
Reber, L. L., & Frossard, N. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.01.004 · Cited by 64 · see citing works
Human eosinophils and mast cells: Birds of a feather flock together
Robida, P. A., Puzzovio, P. G., Pahima, H. T., Levi‐Schaffer, F., & Bochner, B. S. (2018) · Immunological Reviews · doi:10.1111/imr.12638 · Cited by 61 · see citing works
The future of biologics: Applications for food allergy
Bauer, R. N., Manohar, M., Singh, A. M., Jay, D. C., & Nadeau, K. C. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1908 · Cited by 58 · see citing works
Stinging Insect Allergy: State of the Art 2015
Tankersley, M. S., & Ledford, D. K. (2015) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.03.012 · Cited by 57 · see citing works
Buka, R. J., Knibb, R. C., Crossman, R. J., Melchior, C., Huissoon, A. P., Hackett, S. J., Dorrian, S., Cooke, M. W., & Krishna, M. T. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.06.021 · Cited by 54 · see citing works
Leitlinie zu Akuttherapie und Management der Anaphylaxie - Update 2021
Ring, J., Beyer, K., Biedermann, T., Bircher, A. J., Fischer, M. J., Heller, A. R., Huttegger, I., Jakob, T., Klimek, L., Kopp, M., et al. (2021) · Allergo Journal · doi:10.1007/s15007-020-4750-0 · Cited by 54 · see citing works
Where's the Leak in Vascular Barriers? A Review
Kottke, M. A., & Walters, J. (2016) · Shock · doi:10.1097/shk.0000000000000666 · Cited by 53 · see citing works
Inherited and acquired determinants of serum tryptase levels in humans
Lyons, J. J. (2021) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2021.06.019 · Cited by 52 · see citing works
Pathogenesis of IgE‐mediated food allergy
Berin, M. C. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12598 · Cited by 52 · see citing works
Anaphylaxis as a clinical manifestation of clonal mast cell disorders
Matito, A., Alvarez-Twose, I., Morgado, J. M., Sánchez-Muñoz, L., Orfao, A., & Escribano, L. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0450-8 · Cited by 51 · see citing works
Kuruvilla, M. E., & Khan, D. A. (2015) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2015.01.008 · Cited by 50 · see citing works
Greenberger, P. A., & Lieberman, P. L. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.02.012 · Cited by 50 · see citing works
Ulambayar, B., Yang, E., Cha, H., Shin, Y. S., Park, H., & Ye, Y. (2019) · Clinical and Translational Allergy · doi:10.1186/s13601-019-0275-6 · Cited by 50 · see citing works
Overview of Allergy and Anaphylaxis
Dribin, T. E., Motosue, M. S., & Campbell, R. L. (2021) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2021.08.007 · Cited by 49 · see citing works
Leitlinie zu Akuttherapie und Management der Anaphylaxie
Ring, J., Beyer, K., Biedermann, T., Bircher, A. J., Duda, D., Fischer, J., Friedrichs, F., Fuchs, T., Gieler, U., Jakob, T., et al. (2014) · Allergo Journal · doi:10.1007/s15007-014-0542-8 · Cited by 49 · see citing works
Important and specific role for basophils in acute allergic reactions
Korošec, P., Gibbs, B. F., Rijavec, M., Čustović, A., & Turner, P. (2018) · Clinical & Experimental Allergy · doi:10.1111/cea.13117 · Cited by 45 · see citing works
Pathophysiological, Cellular, and Molecular Events of the Vascular System in Anaphylaxis
Nuñez‐Borque, E., Fernández‐Bravo, S., Yuste‐Montalvo, A., & Esteban, V. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.836222 · Cited by 47 · see citing works
The Immunobiology and Treatment of Food Allergy
Barshow, S., Tirumalasetty, J., Sampath, V., Zhou, X., Seastedt, H., Schuetz, J. P., & Nadeau, K. C. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090122-043501 · Cited by 48 · see citing works
Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells
Brailoiu, E., Barlow, C. L., Ramirez, S. H., Abood, M. E., & Brailoiu, G. C. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.039 · Cited by 44 · see citing works
Platelet-Activating Factor (PAF) in Allergic Rhinitis: Clinical and Therapeutic Implications
Muñoz‐Cano, R., Casas‐Saucedo, R., Santiago, A. V., Bobolea, I. D., Ribó, P., & Mullol, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091338 · Cited by 44 · see citing works
Mast cell heterogeneity underlies different manifestations of food allergy in mice
Benedé, S., & Berin, M. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190453 · Cited by 43 · see citing works
Prevention and management of acute reactions to intravenous iron in surgical patients
Gómez‐Ramírez, S., Shander, A., Spahn, D. R., Auerbach, M., Liumbruno, G. M., Vaglio, S., & Múñoz, M. (2018) · Blood transfusion · doi:10.5167/uzh-159250 · Cited by 42 · see citing works
Markers of anaphylaxis – a systematic review
Tomasiak, M. M., Klimek, M., Lis, A., Moniuszko, M., & Bodzenta‐Łukaszyk, A. (2018) · Advances in Medical Sciences · doi:10.1016/j.advms.2017.12.003 · Cited by 41 · see citing works
Sicherer, S. H., & Leung, D. Y. M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.11.013 · Cited by 40 · see citing works
Muñoz‐Cano, R., Pascal, M., Bartra, J., Picado, C., Valero, A., Kim, D., Brooks, S. R., Ombrello, M. J., Metcalfe, D. D., Rivera, J., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.042 · Cited by 40 · see citing works
Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis
Khodoun, M. V., Kucuk, Z. Y., Strait, R. T., Krishnamurthy, D., Janek, K. C., Clay, C. D., Morris, S. C., & Finkelman, F. D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.008 · Cited by 39 · see citing works
Serum levels of 9α,11β-PGF2 and cysteinyl leukotrienes are useful biomarkers of anaphylaxis
Nassiri, M., Eckermann, O., Babina, M., Edenharter, G., & Worm, M. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.07.001 · Cited by 36 · see citing works
Scombroid syndrome: it seems to be fish allergy but... it isn’t
Ridolo, E., Martignago, I., Senna, G., & Ricci, G. (2016) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000297 · Cited by 36 · see citing works
Caiado, J., & Picard, M. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0451-7 · Cited by 36 · see citing works
Metabolomic profiling revealed altered lipid metabolite levels in childhood food allergy
Jang, H., Kim, E. G., Kim, M. N., Kim, S. Y., Kim, Y. H., Sohn, M. H., & Kim, K. W. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.10.034 · Cited by 34 · see citing works
Biomarkers of anaphylaxis, beyond tryptase
Sala-Cunill, A., & Cardona, V. (2015) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000184 · Cited by 32 · see citing works
Emerging Food Allergy Biomarkers
Patil, S. U., Bunyavanich, S., & Berin, M. C. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.04.054 · Cited by 33 · see citing works
Méndez‐Barbero, N., Yuste‐Montalvo, A., Nuñez‐Borque, E., Jensen, B. M., Gutiérrez‐Muñoz, C., Tomé‐Amat, J., Garrido‐Arandia, M., Díaz‐Perales, A., Ballesteros‐Martínez, C., Laguna, J. J., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.09.019 · Cited by 32 · see citing works
Inagaki, S., Maeda, S., Narita, M., Nakamura, T., Shimosawa, T., Murata, T., & Ohya, Y. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.06.032 · Cited by 30 · see citing works
Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria
Zhang, Y., Zhang, H., Du, S., Yan, S., & Zeng, J. (2021) · International Archives of Allergy and Immunology · doi:10.1159/000515753 · Cited by 30 · see citing works
Spontaneous hemoperitoneum and anaphylactic shock associated with Hymenoptera envenomation in a dog
Caldwell, D. J., Petras, K. E., Mattison, B. L., Wells, R. J., & Heffelman, V. L. (2018) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/vec.12751 · Cited by 29 · see citing works
Mast cell activation: beyond histamine and tryptase
Theoharides, T. C., Perlman, A. I., Twahir, A., & Kempuraj, D. (2023) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2200936 · Cited by 27 · see citing works
Ballesteros‐Martínez, C., Méndez‐Barbero, N., Yuste‐Montalvo, A., Jensen, B. M., Gómez‐Cardeñosa, A., Klitfod, L., Garrido‐Arandia, M., Álvarez‐Llamas, G., Pastor‐Vargas, C., Vivanco, F., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01323 · Cited by 27 · see citing works
Tacquard, C. A., Oulehri, W., Collange, O., Garvey, L. H., Nicoll, S., Tuzin, N., Gény, B., & Mertès, P. (2019) · Clinical & Experimental Allergy · doi:10.1111/cea.13540 · Cited by 27 · see citing works
Platelet‐activating factor acetylhydrolase is a biomarker of severe anaphylaxis in children
Upton, J. E. M., Hoang, J. A., Leon‐Ponte, M., Finkelstein, Y., Du, Y. J., Adeli, K., Eiwegger, T., Grunebaum, E., & Vadas, P. (2022) · Allergy · doi:10.1111/all.15308 · Cited by 27 · see citing works
Self-citationIdentifying patients at risk of anaphylaxis
Toit, G. D., Smith, P. K., Muraro, A. M., Fox, A. T., Roberts, G. C., Ring, J., & Worm, M. (2024) · World Allergy Organization Journal · doi:10.1016/j.waojou.2024.100904 · Cited by 28 · see citing works
Secretory and Membrane-Associated Biomarkers of Mast Cell Activation and Proliferation
Parente, R., Giudice, V., Cardamone, C., Serio, B., Selleri, C., & Triggiani, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087071 · Cited by 25 · see citing works
Williams, K. W., & Sharma, H. (2014) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2014.09.010 · Cited by 24 · see citing works
Farbman, K. S., & Michelson, K. A. (2016) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000340 · Cited by 24 · see citing works
Diagnostic Challenges in Anaphylaxis
Lieberman, P., Bingemann, T. A., & Wang, J. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.11.003 · Cited by 24 · see citing works
Perales-Chorda, C., Obeso, D., Twomey, L., Rojas‐Benedicto, A., Puchades‐Carrasco, L., Roca, M., Pineda‐Lucena, A., Laguna, J. J., Barbas, C., Esteban, V., et al. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.13991 · Cited by 23 · see citing works
Sicherer, S. H., & Leung, D. Y. M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.11.007 · Cited by 22 · see citing works
Clinical Characteristics of Inpatients with Anaphylaxis in China
Tang, R., Xu, H., Cao, J., Chen, S., Sun, J., Hu, H., Li, H., Diao, Y., & Li, Z. (2015) · BioMed Research International · doi:10.1155/2015/429534 · Cited by 22 · see citing works
Perelman, B., Adil, A., & Vadas, P. (2014) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-10-20 · Cited by 22 · see citing works
Self-citationPiwowarek, K. Ł., Rzeszotarska, A., Korsak, J., Juszkiewicz, A., Chciałowski, A., & Kruszewski, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256168 · Cited by 21 · see citing works
Zhu, Y., Wang, D. ‐., Liu, B., Hu, Y., Shen, Y., Xu, J., & Tang, H. (2019) · Clinical and Experimental Dermatology · doi:10.1111/ced.14035 · Cited by 21 · see citing works
Guo, X. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i47.13288 · Cited by 21 · see citing works
Mast Cell Desensitization in Allergen Immunotherapy
López‐Sanz, C., Jiménez‐Saiz, R., Esteban, V., Dolset, M. I. D., Perales-Chorda, C., Villaseñor, A., Barber, D., & Escribese, M. M. (2022) · Frontiers in Allergy · doi:10.3389/falgy.2022.898494 · Cited by 20 · see citing works
Using the Right Criteria for MCAS
Gülen, T. (2024) · Current Allergy and Asthma Reports · doi:10.1007/s11882-024-01126-0 · Cited by 20 · see citing works
New Biomarkers in Anaphylaxis (Beyond Tryptase)
Galvan-Blasco, P., Gil-Serrano, J., & Sala-Cunill, A. (2022) · Current Treatment Options in Allergy · doi:10.1007/s40521-022-00326-1 · Cited by 19 · see citing works
IgE and non-IgE-mediated pathways in anaphylaxis
Worm, M., Pažur, K., Morakabati, P., & Redhu, D. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-025-01056-7 · Cited by 23 · see citing works
Brockow, K. (2021) · Journal of Immunological Methods · doi:10.1016/j.jim.2021.113101 · Cited by 20 · see citing works
Andrades, E., Clarós, M., Torres, J. V., Nonell, L., Gonzàlez‐Farré, M., Curto‐Barredo, L., Rozas‐Muñoz, E., Gimeno, R., Barranco, C., Pujol, R. M., et al. (2022) · BioFactors · doi:10.1002/biof.1880 · Cited by 19 · see citing works
Mayorga, C., Fernández‐Santamaría, R., Çelík, G., Labella, M., Murdaca, G., Sokołowska, M., Naisbitt, D. J., & Sabato, V. (2025) · Allergy · doi:10.1111/all.16576 · Cited by 19 · see citing works
Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care
Mabelane, T., & Ogunbanjo, G. A. (2019) · African Journal of Primary Health Care & Family Medicine · doi:10.4102/phcfm.v11i1.1901 · Cited by 18 · see citing works
Food allergy: begin at the skin, end at the mast cell?
Lukacs, N. W., & Hogan, S. P. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01185-y · Cited by 20 · see citing works
Kounis syndrome: a narrative review
Fourie, P. (2016) · Southern African Journal of Anaesthesia and Analgesia · doi:10.1080/22201181.2016.1154309 · Cited by 16 · see citing works
Risk factors for fatal anaphylaxis
Pumphrey, R. S. H., & Sturm, G. J. (2014) · doi:10.2217/fmeb2013.13.248 · Cited by 16 · see citing works
Akin, C., Siebenhaar, F., Wechsler, J. B., Youngblood, B. A., & Maurer, M. (2024) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2024.03.010 · Cited by 15 · see citing works
- Authors
- Vadas, P., Perelman, B., & Liss, G.
- Affiliations
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Corresponding author
- Vadas, Peter
- ORCID
- Vadas, Peter
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 131
- Issue
- 1
- Pages
- 144-149
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2048983224
- Cited by
- 223
- References
- 30
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 16 · 2023: 11 · 2022: 19 · 2021: 19 · 2020: 15 · 2019: 16 · 2018: 17 · 2017: 11 · 2016: 17 · 2015: 26 · 2014: 18 · 2013: 15 · 2012: 1
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- platelet-activating factor, histamine, tryptase, anaphylaxis, anaphylaxis severity, acute allergic reactions, severity classification
- MeSH terms
- Adolescent, Adult, Aged, Anaphylaxis, Cross-Sectional Studies, Female, Histamine, Humans, Male, Middle Aged, Platelet Activating Factor, Tryptases, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
