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Cited by 131Antifungal resistance and susceptibilityNeutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

The role of neutrophils in host defense against invasive fungal infections

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Desai, Jigar V., Lionakis, Michail S.·2018·Current Clinical Microbiology Reports
DOI 10.1007/s40588-018-0098-6PMC PMC6758935
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Abstract

Purpose of review Invasive fungal infections caused by the commensal yeast Candida and the ubiquitous, inhaled mold Aspergillus have emerged as major causes of morbidity and mortality in critically ill and immunosuppressed patient populations. Here, we review how neutrophils contribute to effective immunity against these infections. Recent findings Studies in mouse models of invasive candidiasis and aspergillosis, and observations in hematological patients with chemotherapy-induced neutropenia and in patients with primary immunodeficiency disorders that manifest with these infections have highlighted the critical role of neutrophils and have identified key immune factors that promote neutrophil-mediated effective host defense against invasive fungal disease. Summary Neutrophils are crucial in host protection against invasive candidiasis and aspergillosis. Recent advances in our understanding of the molecular cues that mediate protective neutrophil recruitment and effector function against these infections hold promise for developing immune-based strategies to improve the outcomes of affected patients.

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  • In an intradermal mouse model of C. auris skin infection, scRNA-seq identifies a fibroblast subset expressing adipocyte lineage markers as the only proliferating non-immune cell population.

    “Utilizing an intradermal mouse model of C. auris skin infection, scRNA-seq identified a fibroblast subset expressing adipocyte lineage markers as the only proliferating non-immune cell population [83], suggesting an analogous reactive adipogenesis during cutaneous C. auris infection.”

    From Host–Candida auris interactions in the skin (2026) · cites this paper as [83]

    The cited review’s sections on Candida albicans and Aspergillus infections discuss neutrophil recruitment and antifungal activity, not the claimed C. auris skin model. Searches for intradermal C. auris infection, scRNA-seq, adipocyte-lineage fibroblasts, and proliferating non-immune cells found no passage addressing the claim in our copy. (LLM, conf=0.76)

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  • Non-immune stromal cells mount a coordinated innate response during C. auris infection, coupling structural maintenance with immune activation.

    “Together, these findings demonstrate that non-immune stromal cells mount a coordinated innate response during C. auris infection, coupling structural maintenance with immune activation.”

    From Host–Candida auris interactions in the skin (2026) · cites this paper as [83]

    The sections on anti-Candida albicans and anti-Aspergillus fumigatus neutrophil effector functions discuss immune-cell interactions, not a stromal-cell response to C. auris. Searches for C. auris, non-immune stromal cells, and structural maintenance found no passage addressing the attributed claim. No page numbers were provided in our copy. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Desai, J. V., & Lionakis, M. S.
Affiliations
National Institutes of Health (US)
Corresponding author
Lionakis, Michail S.
ORCID
Venue
Current Clinical Microbiology Reports
Publisher
Springer Science and Business Media LLC
Published
2018-06-22
Volume
5
Issue
3
Pages
181-189
ISSN
2196-5471 (ISSN-L)
DOI
10.1007/s40588-018-0098-6
PMC
PMC6758935
OpenAlex
W2809161821
Cited by
131
References
10
Citations by year
2026: 12 · 2025: 26 · 2024: 20 · 2023: 14 · 2022: 27 · 2021: 22 · 2020: 10
FWCI
6.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Clinical Microbiology Reports (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
neutrophils, invasive fungal infections, invasive candidiasis, aspergillosis, host defense, neutrophil recruitment, neutrophil effector functions, chemotherapy-induced neutropenia, primary immunodeficiency, immunosuppression, critically ill patients

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