The role of Syk/CARD9 coupled C-type lectins in antifungal immunity
Open accessAbstract
Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-κB activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.
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CLEC7A is a canonical fungal pathogen receptor that signals through SYK in the periphery and has been identified to be upregulated in stage 2 DAM.
“CLEC7A is a canonical fungal pathogen receptor that signals through SYK in the periphery and has recently been identified to be upregulated in stage 2 DAM (Drummond et al., 2011; Keren-Shaul et al., 2017).”
From SYK coordinates neuroprotective microglial responses in neurodegenerative disease (2022) · cites this paper as Drummond et al., 2011
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Research works printed but not linked: 3
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“CLEC7A is a canonical fungal pathogen receptor that signals through SYK in the periphery and has recently been identified to be upregulated in stage 2 DAM (Drummond et al., 2011; Keren-Shaul et al., 2017).”
Role of dectin-2 for host defense against systemic infection with Candida glabrata
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Self-citation
- Authors
- Drummond, R. A., Saijo, S., Iwakura, Y., & Brown, G. D.
- Affiliations
- University of Aberdeen (GB)
- Chiba University (JP)
- The University of Tokyo (JP)
- Corresponding author
- Brown, Gordon D.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2011-01-11
- Volume
- 41
- Issue
- 2
- Pages
- 276-281
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- PMC
- PMC3434674
- OpenAlex
- W1996644651
- Cited by
- 221
- References
- 49
- Citations by year
- 2026: 12 · 2025: 6 · 2024: 8 · 2023: 15 · 2022: 16 · 2021: 14 · 2020: 23 · 2019: 10 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 12 · 2014: 18 · 2013: 25 · 2012: 22
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Immunology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (publishedVersion, other-oa)
- Funders
- Wellcome Trust (086558)
- Japan Society for the Promotion of Science (23390101)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- C-type lectin receptors, Syk, CARD9, antifungal immunity, fungal infection, pattern recognition receptors, Dectin-1, Dectin-2, Mincle, NF-κB activation, innate immunity, signal transduction, immunotherapy
- MeSH terms
- Syk Kinase, Animals, Humans, Mycoses, Protein-Tyrosine Kinases, Signal Transduction, Lectins, C-Type, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, CARD Signaling Adaptor Proteins
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