Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome

Kaya, Z.; Caglayan, S.; Akkiprik, M.; Aral, C.; Ozisik, G.; Ozata, M.; Ozer, A.

doi:10.1007/s40618-015-0409-1

Cited by 19Diabetes, Cardiovascular Risks, and LipoproteinsGenetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome

Kaya, Z., Caglayan, S., Akkiprik, M., Aral, C., Ozisik, G., Ozata, M., Ozer, A.·2016·Journal of Endocrinological Investigation

DOI 10.1007/s40618-015-0409-1

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Abstract

Background The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS.Materials and methods Seventy subjects with MetS and 185 healthy controls were enrolled in the study. PCR-RFLP analysis was used for genotyping. Results for each polymorphism have been verified by allele-specific oligonucleotide analysis.Results BclI GG genotype was significantly associated with an increased risk of MetS (p = 0.02). Also, only in women, the G allele carriers were significantly associated with higher C-peptide. T allele carriers of TthIII1 polymorphism were significantly associated with higher C-peptide, triglyceride, insulin and C-reactive protein (CRP, p value 0.048, 0.022, 0.005 and 0.022, respectively), and lower fasting blood glucose (FBG, p = 0.02). The combined carriers of BclI polymorphism G allele and TthIII1 polymorphism T allele were significantly associated with higher diastolic blood pressure in all patients, and lower FBG and postprandial blood glucose in only men. All the ER22/23EK polymorphisms coexisted with polymorphic variant of TthIII1 (p = 0.0058).Conclusion The presence of homozygote polymorphic variant of BclI might be good predictive markers for the disease susceptibility. The BclI and the TthIII1 polymorphism are associated with sex-specific clinical parameters. Our findings also suggest that the combination of BclI and TthIII1 polymorphisms may play a protective role in blood glucose.

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From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [81]
Cortisol plays a significant role in muscle proteolysis during caloric restriction.
“Cortisol, a catabolic hormone, plays a significant role in muscle proteolysis during caloric restriction.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [81]

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Authors: Kaya, Z., Caglayan, S., Akkiprik, M., Aral, C., Ozisik, G., Ozata, M., & Ozer, A.
Affiliations: Van Yüzüncü Yıl Üniversitesi (TR)
Tekirdağ Namık Kemal University (TR)
ORCID: Kaya, Z.
Aral, C.
Venue: Journal of Endocrinological Investigation
Publisher: Springer Science and Business Media LLC
Published: 2015-11-23
Volume: 39
Issue: 5
Pages: 557-566
ISSN: 0391-4097 (ISSN-L)
1720-8386
DOI: 10.1007/s40618-015-0409-1
OpenAlex: W2274813852
Cited by: 19
References: 36
Citations by year: 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 3 · 2017: 2
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Endocrinological Investigation (publishedVersion)
PubMed (publishedVersion)
Van Yüzüncü Yıl University Academic Data Management System (submittedVersion)
Dspace Repository (Marmara Üniversitesi) (submittedVersion)
Funders: Türkiye Bilimsel ve Teknolojik Araştirma Kurumu (TR) (104S272, SBAG-K-60)
The Research Foundation of Marmara University (BAPKO) (SAG-C-DRP-101011-0286)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: metabolic syndrome, glucocorticoid receptor, NR3C1 gene, genetic polymorphism, BclI polymorphism, ER22/23EK polymorphism, N363S polymorphism, genetic susceptibility, sex differences, insulin resistance, blood glucose, C-peptide, C-reactive protein, triglycerides, diastolic blood pressure, Turkish population
MeSH terms: Adult, Female, Genotype, Humans, Male, Polymorphism, Genetic, Receptors, Glucocorticoid, Polymorphism, Restriction Fragment Length, Risk Factors, Turkey, Prevalence, Case-Control Studies, Polymerase Chain Reaction, Genetic Predisposition to Disease, Metabolic Syndrome

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Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome

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