The treatment of hyperinsulinemic hypoglycaemia in adults: an update
Open accessAbstract
Background Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. Methods A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. Results One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. Conclusions New approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local-regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Functional β-cell disorders are also known as adult-onset nesidioblastosis or non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS).
“The latter are a group of diseases also known as adult-onset nesidioblastosis or non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) [5,16-20].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cryer, P. E., Axelrod, L., Grossman, A. B., Heller, S. R., Montori, V. M., Seaquist, E. R., & Service, F. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1410 · Cited by 1,277 · see citing works
ARIOGLU, E., ANDEWELT, A., DIABO, C., BELL, M., TAYLOR, S. I., & GORDEN, P. (2002) · Medicine · doi:10.1097/00005792-200203000-00001 · Cited by 223 · see citing works
Vilarrasa, N., Goday, A., Rubio, M. A., Caixàs, A., Pellitero, S., Ciudin, A., Calañas, A., Botella, J. I., Bretón, I., Morales, M. J., et al. (2016) · Obesity Facts · doi:10.1159/000442764 · Cited by 197 · see citing works
Anlauf, M., Wieben, D., Perren, A., Sipos, B., Komminoth, P., Raffel, A., Kruse, M. L., Fottner, C., Knoefel, W. T., Mönig, H., et al. (2005) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000151617.14598.ae · Cited by 167 · see citing works
Clancy, T. E., Moore, F. D., & Zinner, M. J. (2006) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2006.04.008 · Cited by 133 · see citing works
Severe Recurrent Hypoglycemia after Gastric Bypass Surgery
Z’graggen, K., Guweidhi, A., Steffen, R., Potoczna, N., Biral, R., Walther, F., Komminoth, P., & Horber, F. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9480-4 · Cited by 125 · see citing works
Adult diffuse nesidioblastosis: genetically or environmentally induced?
Klöppel, G., Anlauf, M., Raffel, A., Perren, A., & Knoefel, W. T. (2008) · Human Pathology · doi:10.1016/j.humpath.2007.09.010 · Cited by 108 · cited 1× · see citing works
“1 3 combined hyperplasia, diffuse proliferation and hypertrophy of islet cells from pancreatic ducts [100, 101].”
BackgroundRumilla, K. M., Erickson, L. A., Service, F. J., Vella, A., Thompson, G. B., Grant, C. S., & Lloyd, R. V. (2009) · Modern Pathology · doi:10.1038/modpathol.2008.169 · Cited by 85 · cited 1× · see citing works
“Further, other factors such as IGF-2, IGF-1 alpha receptor, TGF beta receptor and ghrelin might be involved in nesidioblastosis pathogenesis [118].”
BackgroundRecurrent Hypoglycemia from Insulin Autoimmune Syndrome
Wong, S. L., Priestman, A., & Holmes, D. T. (2014) · Journal of General Internal Medicine · doi:10.1007/s11606-013-2588-9 · Cited by 73 · see citing works
Vanderveen, K. A., Grant, C. S., Thompson, G. B., Farley, D. R., Richards, M. L., Vella, A., Vollrath, B., & Service, F. J. (2010) · Surgery · doi:10.1016/j.surg.2010.09.027 · Cited by 67 · see citing works
Hypoglycemia due to an insulin binding antibody in a patient with an IgA-κ myeloma.
Halsall, D. J., Mangi, M., Soos, M., Fahie-Wilson, M. N., Wark, G., Mainwaring-Burton, R., & O’Rahilly, S. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0075 · Cited by 56 · see citing works
Flagged first, then by citations
Research works printed but not linked: 13
- [8]8. Partelli S, Maurizi A, Tamburrino D, Baldoni A, Polenta V , Crippa S, Falconi M (2014) GEP-NETS update: a review on surgery of gastro-entero-pancreatic neuroendocrine tumors. Eur J Endocrinol 171:153-162
- [23]23. Mehrabi A, Fischer L, Hafezi M, Dirlewanger A, Grenacher L, Diener MK, Fonouni H, Golriz M, Garoussi C, Fard N, Rahbari NN, Werner J, Büchler MW (2014) A systematic review of localization, surgical treatment options, and outcome of insulinoma. Pancreas 43:675-686
- [33]33. de Herder WW, Niederle B, Scoazec JY, Pauwels S, Kloppel G, Falconi M, Kwekkeboom DJ, Oberg K, Eriksson B, Wiedenmann B, Rindi G, O'Toole D, Ferone D, Frascati Consensus Conference, European Neuroendocrine Tumor Society (2006) Well-differentiated pancreatic tumor/carcinoma: insulinoma. Neuroendocrinology 84:183-188
- [47]47. Jensen RT, Cadiot G, Brandi ML, de Herder WW, Kaltsas G, Komminoth P, Scoazec JY, Salazar R, Sauvanet A, Kianmanesh R, Barcelona Consensus Conference Participants (2012) ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes. Neuroendocrinology 95:98-119
- [80]80. Eriksson B, Annibale B, Bajetta E, Mitry E, Pavel M, Platania M, Salazar R, Plöckinger U, Mallorca Consensus Conference participants; European Neuroendocrine Tumor Society (2009) ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: chemotherapy in patients with neuroendocrine tumors. Neuroendocrinology 90:214-219
- [81]81. Dussol AS, Joly MO, Vercherat C, Forestier J, Hervieu V, Scoazec JY, Lombard-Bohas C, Walter T (2015) Gemcitabine and oxaliplatin or alkylating agents for neuroendocrine tumors: comparison of efficacy and search for predictive factors guiding treatment choice. Cancer 121(19):3428-3434
- [85]85. Pavel M, Baudin E, Couvelard A, Krenning E, Öberg K, Steinmüller T, Anlauf M, Wiedenmann B, Salazar R (2012) <!-- image --> - Barcelona Consensus Conference participants: ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 95:157-176
- [88]88. Strosberg JR, Cheema A, Kvols LK (2011) A review of systemic and liver-directed therapies for metastatic neuroendocrine tumors of the gastroenteropancreatic tract. Cancer Control 18:127-137
- [91]91. Berwaerts J, Verhelst J, Hubens H et al (1997) Role of hepatic arterial embolisation in the treatment of malignant insulinoma. Report of two cases and review of the literature. Acta Clin Belg 52:263-274
- [93]93. Starke A, Saddig C, Mansfeld L, Koester R, Tschahargane C, Czygan P, Goretzki P (2005) Malignant metastatic insulinoma-postoperative treatment and follow-up. World J Surg 29(6):789-793
- [96]96. Van Schaik E, van Vliet EI, Feelders RA, Krenning EP, Khan S, Kamp K, Valkema R, van Nederveen FH, Teunissen JJ, Kwekkeboom DJ, de Herder WW (2011) Improved control of severe hypoglycaemia in patients with malignant insulinomas by peptide receptor radionuclide therapy. J Clin Endocrinol Metab 96(11):3381-3389
- [102]102. Service FJ (1993) Clinical review 42: hypoglycaemias. J Clin Endocrinol Metab 76:269-272
- [121]121. Won JG, Tseng HS, Yang AH, Tang KT et al (2006) Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS). Clin Endocrinol (Oxf) 65(5):566-578
Cited by
Sorted by citations
Yamada, Y., Kitayama, K., Oyachi, M., Higuchi, S., Kawakita, R., Kanamori, Y., & Yorifuji, T. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13180 · Cited by 63 · see citing works
Dieterle, M. P., Husari, A., Prozmann, S. N., Wiethoff, H., Stenzinger, A., Röhrich, M., Pfeiffer, U., Kießling, W. R., Engel, H., Sourij, H., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11061741 · Cited by 5 · see citing works
- Authors
- On behalf of NIKE Group, Davi′, M. V., Pia, A., Guarnotta, V., Pizza, G., Colao, A., & Faggiano, A.
- Affiliations
- University of Verona (IT)
- Ospedale San Luigi Gonzaga (IT)
- Federico II University Hospital (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Venue
- Journal of Endocrinological Investigation
- Published
- 2016-09-13
- Volume
- 40
- Issue
- 1
- Pages
- 9-20
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- OpenAlex
- W2520440653
- Cited by
- 51
- References
- 11
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 10 · 2018: 2 · 2017: 5 · 2016: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Endocrinological Investigation (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- insulinoma, nesidioblastosis, gastric bypass, minimally invasive surgery, everolimus, malignant insulinoma, differential diagnosis
- MeSH terms
- Adult, Humans, Hyperinsulinism, Hypoglycemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
