Outcomes and quality of life after partial pancreatectomy for noninsulinoma pancreatogenous hypoglycemia from diffuse islet cell disease
Open accessAbstract
Background Noninsulinoma pancreatogenous hypoglycemia (NIPH) is a rare cause of hypoglycemia, especially affecting postbariatric surgery patients, related to excessive insulin secretion. Partial pancreatectomy controls hypoglycemia in the early postoperative period; however, multiple patients have experienced symptomatic relapse. The study goal was to assess frequency and severity of recurrent symptoms in operated patients. Methods All patients who underwent pancreatic resection for NIPH at Mayo Clinic from January 1996 through December 2008 were reviewed for demographics, preoperative testing, operative and postoperative details. Data from patient records, mail survey, European Quality of Life Survey (EQ-5D), and Fear of Hypoglycemia Scale (FOHS) were used to assess outcome. Results Seventy-five patients underwent pancreatic resection for NIPH (5 dead, 1 incarcerated). 48 patients (70%) completed the survey; mean follow-up, 53 months. Median time to recurrent symptoms was 16 months in 41 patients (87%). Despite symptom recurrence, 36 patients (75%) reported overall improvement in symptoms and quality of life (QOL); median EQ-5D health scores increased from 40 to 75 out of 100 (P < .001). Moreover, they reported marked reduction in psychologic stress and hypoglycemic symptoms with greater than 50% decrease in FOHS overall, worry, and behavioral median scores (P < .001). Overall, half of the patients were classified as highly/moderately surgically successful, whereas the other half was minimally successful or surgical failures. Conclusion Although nearly 90% of NIPH patients reported recurrent symptoms suggestive of hypoglycemia, a majority reported improvements in QOL and marked reduction in other symptoms after pancreatic resection. Nevertheless, 25% of patients experienced no benefit from partial pancreatectomy.
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Various surgical re-interventions have been used, including gastric tube placement, gastric bypass reversal with or without concomitant sleeve resection and gastric pouch restriction.
“Various surgical re-interventions have been used, including gastric tube placement, gastric bypass reversal with or without concomitant sleeve resection and gastric pouch restriction (Table 5) (66,103,105-123).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [105]
The Results (page not provided) report feeding-tube placement and gastric-bypass revision as additional operations; the Discussion describes gastric re-restriction procedures. The paper does not specify that the feeding tube was gastric or describe bypass reversal with or without sleeve resection. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPancreatic resection, the most commonly reported procedure, was performed in approximately 67% of patients.
“Pancreatic resection, the most commonly reported procedure, was performed in approximately 67% of patients (66,103,105,107,114,116-123).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [105]
The Results (page not provided) report 75 patients who underwent pancreatic resection for noninsulinoma pancreatogenous hypoglycemia. The paper studies resection patients rather than comparing procedures across a broader patient group, so it does not establish that resection was the most commonly reported procedure or was performed in approximately 67% of patients. (LLM, conf=0.86)
Experimental — accuracy not yet measuredFewer than half of patients (48%) were deemed to have achieved a highly or moderately successful surgical outcome, and 25% experienced no apparent benefit.
“Fewer than half of patients (48%) were deemed to have achieved a highly or moderately successful surgical outcome, and 25% experienced no apparent benefit (105).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [105]
A study of patients who underwent partial pancreatectomy because of noninsulinoma pancreatogenous hypoglycemia demonstrated that nearly 90% experienced recurrent symptoms suggestive of hypoglycemia.
“A study of patients who underwent partial pancreatectomy because of noninsulinoma pancreatogenous hypoglycemia demonstrated that nearly 90% experienced recurrent symptoms suggestive of hypoglycemia (105).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [105]
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Cites
Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery.
Service, G. J., Thompson, G. B., Service, F. J., Andrews, J. C., Collazo-Clavell, M. L., & Lloyd, R. V. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043690 · Cited by 779 · see citing works
Self-citationFear of hypoglycemia: quantification, validation, and utilization
Cox, D. J., Irvine, A., Gonder-Frederick, L., Nowacek, G., & Butterfield, J. (1987) · Diabetes Care · doi:10.2337/diacare.10.5.617 · Cited by 579 · see citing works
Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery.
Kaiser, A. (2005) · New England Journal of Medicine · doi:10.1056/nejm200511173532017 · Cited by 330 · see citing works
Service, F. J., Natt, N., Thompson, G. B., Grant, C. S., van Heerden, J. A., Andrews, J. C., Lorenz, E., Terzic, A., & Lloyd, R. V. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5645 · Cited by 196 · see citing works
Self-citationMoreira, R. O., Moreira, R., Machado, N., Gonçalves, T. B., & Coutinho, W. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9569-9 · Cited by 136 · see citing works
Severe Recurrent Hypoglycemia after Gastric Bypass Surgery
Z’graggen, K., Guweidhi, A., Steffen, R., Potoczna, N., Biral, R., Walther, F., Komminoth, P., & Horber, F. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9480-4 · Cited by 125 · see citing works
Noninsulinoma pancreatogenous hypoglycemia syndrome: An update in 10 surgically treated patients
Thompson, G. B., Service, F. J., Andrews, J. C., Lloyd, R. V., Natt, N., van Heerden, J. A., & Grant, C. S. (2000) · Surgery · doi:10.1067/msy.2000.110243 · Cited by 121 · see citing works
Self-citationWitteles, R., Straus, F., Sugg, S., Koka, M. R., Costa, E. A., & Kaplan, E. (2001) · Archives of Surgery · doi:10.1001/archsurg.136.6.656 · Cited by 120 · see citing works
Advances in the diagnosis and management of hyperinsulinemic hypoglycemia
Kapoor, R. R., James, C. T., & Hussain, K. (2009) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet1046 · Cited by 104 · see citing works
Won, J. G., Tseng, H.-S., Yang, A.-H., Tang, K.-T., Jap, T., Lee, C.-H., Lin, H.-D., Burcus, N. I., Pittenger, G., & Vinik, A. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02629.x · Cited by 95 · see citing works
Raffel, A., Krausch M, M., Anlauf, M., Wieben, D., Braunstein, S., Klöppel, G., Röher, H.-D., & Knoefel, W. T. (2007) · Surgery · doi:10.1016/j.surg.2006.04.015 · Cited by 81 · see citing works
Noninsulinoma Pancreatogenous Hypoglycemia Syndrome: A Rare Case of Adult-onset Nesidioblastosis
TSUJINO, M., SUGIYAMA, T., NISHIDA, K., TAKADA, Y., TAKANISHI, K., ISHIZAWA, M., & HIRATA, Y. (2005) · Internal Medicine · doi:10.2169/internalmedicine.44.843 · Cited by 24 · see citing works
Noninsulinoma pancreatogenous hypoglycemia syndrome in a Saudi male.
Karawagh, A., Abdullah, L., Gasim, A., & Abdelaziz, M. (2008) · Saudi Medical Journal · doi:10.15537/1658-3175.4545 · Cited by 4
Flagged first, then by citations
Cited by
Sorted by citations
van Beek, A. P., Emous, M., Laville, M., & Tack, J. (2017) · Obesity Reviews · doi:10.1111/obr.12467 · Cited by 288 · see citing works
“demonstrated that nearly 90% experienced recurrent symptoms suggestive of hypoglycemia (105).”
BackgroundInfluentialInternational consensus on the diagnosis and management of dumping syndrome
Scarpellini, E., Arts, J., Karamanolis, G., Laurenius, A., Siquini, W., Suzuki, H., Ukleja, A., van Beek, A. V., Vanuytsel, T., Bor, S., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0357-5 · Cited by 247 · see citing works
Hypoglycemia After Gastric Bypass Surgery: Current Concepts and Controversies
Salehi, M., Vella, A., McLaughlin, T., & Patti, M.-E. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00528 · Cited by 239 · see citing works
“resolving hypoglycemia over time in post-RYGB patients (38) also suggests that increased b-cell mass is not the”
BackgroundSelf-citationGlucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia
Sandoval, D. A., & Patti, M. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00757-5 · Cited by 190 · see citing works
Kefurt, R., Langer, F., Schindler, K., Shakeri-Leidenmühler, S., Ludvik, B., & Prager, G. (2015) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.11.003 · Cited by 143 · see citing works
“[15,32], verapamil [33] or diazoxide [34] as drug therapy or surgical interventions such as secondary bypass banding [35,36], bypass reversal [37,38] or pancreatic resection [24– 27,39].”
BackgroundASMBS Position Statement on Postprandial Hyperinsulinemic Hypoglycemia after Bariatric Surgery.
Eisenberg, D., Azagury, D., Ghiassi, S., Grover, B. T., & Kim, J. J. (2017) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.12.005 · Cited by 121 · see citing works
MANAGEMENT OF ENDOCRINE DISEASE: Pathogenesis and management of hypoglycemia
Kittah, N. E., & Vella, A. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-1062 · Cited by 107 · see citing works
Self-citationThompson, S. M., Vella, A., Thompson, G. B., Rumilla, K. M., Service, F. J., Grant, C. S., & Andrews, J. C. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2404 · Cited by 80 · see citing works
“The approach to management of endogenous hyperinsulinemic hypoglycemia at our institution has been described previously (1, 7, 8, 15).”
BackgroundMethodSelf-citationApproach to the patient with spontaneous hypoglycemia
Martens, P., & Tits, J. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2014.02.011 · Cited by 74 · see citing works
“Therefore it should only be considered in patient who fails medical therapy and who suffers from severe debilitating neuroglycopenic symptoms [44].”
BackgroundInfluentialCraig, C. M., Lawler, H. M., Lee, C. J. E., Tan, M., Davis, D. B., Tong, J., Glodowski, M., Rogowitz, E., Karaman, R., McLaughlin, T. L., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab103 · Cited by 69 · see citing works
Davis, D., Khoraki, J., Ziemelis, M., Sirinvaravong, S., Han, J.-Y., & Campos, G. M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2017.12.011 · Cited by 64 · see citing works
“Of patients who underwent partial pancreatectomy, 90% experienced recurrent symptoms and 25% experienced no improvement in quality of life [12].”
BackgroundPostprandial hyperinsulinemic hypoglycemia after gastric bypass surgical treatment
Mala, T. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.01.010 · Cited by 75 · see citing works
The treatment of hyperinsulinemic hypoglycaemia in adults: an update
On behalf of NIKE Group, Davi′, M. V., Pia, A., Guarnotta, V., Pizza, G., Colao, A., & Faggiano, A. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0536-3 · Cited by 51 · see citing works
Vargas, E., Dayyeh, B. A., Storm, A. C., Bazerbachi, F., Matar, R., Vella, A., Kellogg, T., & Stier, C. (2020) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2020.02.029 · Cited by 48 · see citing works
Self-citationDiarrhea after bariatric procedures: Diagnosis and therapy
Borbély, Y., Osterwalder, A., Kröll, D., Nett, P. C., & Inglin, R. A. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i26.4689 · Cited by 54 · see citing works
Spontaneous hypoglycemia: diagnostic evaluation and management
Kandaswamy, L., Raghavan, R., & Pappachan, J. M. (2016) · Endocrine · doi:10.1007/s12020-016-0902-0 · Cited by 38 · see citing works
“A majority of reported cases in adults were following bariatric surgery, and the incidence of NIPHS cases has increased recently, possibly because of increased awareness of this syndrome and a higher frequency of gastric bypass procedures in recent years [39, 40].”
BackgroundSheehan, A., & Patti, M. E. (2020) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s233078 · Cited by 39 · see citing works
Post‐gastric bypass hypoglycaemia: a review
Shantavasinkul, P. C., Torquati, A., & Corsino, L. (2016) · Clinical Endocrinology · doi:10.1111/cen.13033 · Cited by 39 · see citing works
Hazlehurst, J., Khoo, B. C. E., Lobato, C. B., Ilesanmi, I., Abbott, S., Chan, T. L., Pillai, S., Maslin, K., Purkayastha, S., McGowan, B. M., et al. (2024) · Endocrine Connections · doi:10.1530/ec-23-0285 · Cited by 43 · see citing works
“PBH is associated with a lower quality of life, which improves after treatment (4).”
Thompson, S. M., Vella, A. V., Service, F. J., Grant, C. S., Thompson, G. B., & Andrews, J. C. (2015) · Surgery · doi:10.1016/j.surg.2015.03.004 · Cited by 27 · see citing works
“NIPHS patients may be offered partial pancreatectomy to reduce their b islet cell mass and hypoglycemic symptoms.(33) Interestingly, there were 4 patients with surgically confirmed insulinoma in the present cohort who developed postprandial hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass surgery.”
Self-citationCommon and Rare Complications of Bariatric Surgery
Collazo–Clavell, M. L., & Shah, M. (2020) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2020.02.003 · Cited by 30 · see citing works
Masclee, G. M. C., & Masclee, A. (2023) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s392265 · Cited by 32 · see citing works
“64 67 Surgical re-intervention after RYGB can be technically challenging, first, as a result of altered anatomy and, second, because of adhesions, resulting in a higher number of adverse events and vagal nerve damage.”
BackgroundMulla, C., Zavitsanou, S., Sanz, A. L. L., Pober, D. M., Richardson, L., Walcott, P., Arora, I., Newswanger, B., Cummins, M. J., Prestrelski, S., et al. (2019) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/clinem/dgz197 · Cited by 24 · see citing works
Dieterle, M. P., Husari, A., Prozmann, S. N., Wiethoff, H., Stenzinger, A., Röhrich, M., Pfeiffer, U., Kießling, W. R., Engel, H., Sourij, H., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11061732 · Cited by 19 · see citing works
Surgical Treatment for Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass: a Literature Review
Xu, Q., Zou, X., You, L., Wu, W., Zhu, H., Wang, L., Yuan, T., & Zhao, Y. (2021) · Obesity Surgery · doi:10.1007/s11695-021-05251-x · Cited by 20 · see citing works
“The incidence of operative complications reached 38%, including pancreatic leakage and fistula, and approximately 20% of the patients developed diabetes after pancreatectomy [47].”
BackgroundPatti, M., Goldfine, A. B., Hu, J., Hoem, D., Molven, A., Goldsmith, J. D., Schwesinger, W. H., Rosa, S. L., Folli, F. B., & Kulkarni, R. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1001-2 · Cited by 17 · see citing works
“While some patients experience initial improvements following partial pancreatectomy, hypoglycemia often recurs [4, 21], suggesting progressive b-cell dysregulation and inappropriate insulin secretion.”
BackgroundInfluentialde Heide, L. J. M., Wouda, S. H. T., Peters, V. J. T., Oosterwerff‐Suiker, M., Gerdes, V. A., Emous, M., & van Beek, A. P. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14920 · Cited by 15 · see citing works
“The duration of TABLE 1 Patient characteristics, surgical procedures and hypoglycaemia data Patients N = 120 Female, n (%) 102 (85) Age (years) 41 [33-49] BMI (kg/m(2)) 42.”
BackgroundEvers, S. S., Kim, K., Bozadjieva-Kramer, N., Lewis, A. G., Farris, D. M., Sorensen, M. J., Kim, Y., Whitesall, S. E., Kennedy, R. T., Michele, D. E., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.011 · Cited by 18 · see citing works
“Although there was initial enthusiasm for partial pancreatectomy to reduce islet mass, recurrence of hypoglycemia with time was observed, underscoring the complex interactions beyond insulin secretion that contribute to hypoglycemia [13].”
BackgroundDumping syndrome : Update on pathophysiology, diagnosis, and management
Tack, J. F., Raymenants, K., de Bruaene, C. V., & Scarpellini, E. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14962 · Cited by 12 · see citing works
Hyperinsulinemic hypoglycemia after gastric bypass surgery: what’s up and what’s down?
Yaqub, A., Smith, E. P., & Salehi, M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.257 · Cited by 12 · see citing works
Can reversal of RYGB also reverse hypoglycemia?
Arora, I., & Patti, M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.004 · Cited by 13 · see citing works
Insulinoma or non-insulinoma pancreatogenous hypoglycemia? A diagnostic dilemma
Anderson, B. L., Nostedt, J. J., Girgis, S., Dixon, T., Agrawal, V., Wiebe, E., Senior, P. A., & Shapiro, A. M. J. (2016) · Journal of Surgical Case Reports · doi:10.1093/jscr/rjw188 · Cited by 11 · see citing works
“A notable study from the Mayo Clinic demonstrated improved quality of life following pancreatic resection; symptom recurrence, when present, was usually less severe and debilitating than previous [3].”
BackgroundHypoglycemia after bariatric surgery: Management updates
Iqbal, A., & Makin, V. (2025) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.92a.24033 · Cited by 13 · see citing works
“44,45 ■ CONCLUSION While bariatric surgery is an excellent treatment for obesity and its complications, the long-term repercussions of recurrent hypoglycemia may lead to impaired quality of life, motor-vehicle accidents, cardiovascular events, and regain of body weight (due to overcom-pensation by…”
Patience, N., Sheehan, A., Cummings, C., & Patti, M. (2022) · Current Obesity Reports · doi:10.1007/s13679-022-00482-0 · Cited by 12 · see citing works
Pramlintide for Post-Bariatric Hypoglycemia
Sheehan, A., Goldfine, A., Bajwa, M., Wolfs, D., Kozuka, C., Piper, J., Fowler, K. M., & Patti, M. (2022) · Diabetes, obesity and metabolism · doi:10.1111/dom.14665 · Cited by 11 · see citing works
Potential contribution of the gut microbiota to hypoglycemia after gastric bypass surgery
Zhou, L., Deng, M., & Xiao, X. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000932 · Cited by 10 · see citing works
Ball, C., Grondin, S., Pasieka, J., Kirkpatrick, A., Maclean, A., Cantle, P. M., Dixon, E., Schneider, P., & Hamilton, M. (2018) · Journal of Comparative Effectiveness Research · doi:10.2217/cer-2017-0090 · Cited by 11 · see citing works
Total Pancreatectomy for the Management of Refractory Post-Gastric Bypass Hypoglycemia
Spolverato, G., Bhaijee, F., Anders, R., Salley, K. E. S., Parambi, J., Brown, T., & Pawlik, T. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3408-8 · Cited by 7 · see citing works
“While some studies report symptoms relief after partial pancreatectomy [32, 33], others described minimal improvements in symptoms and quality of life [12, 14].”
BackgroundDiagnosis and management of post-bariatric surgery hypoglycemia
Alkhaled, L., Al‐Kurd, A., Butsch, W. S., Kashyap, S. R., & Aminian, A. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2267136 · Cited by 9 · see citing works
“Several reports have demonstrated no or minimal benefit and recurrence of symptoms following partial pancreatectomy [76,77].”
BackgroundCao, J., Kim, C., Huynh, T., Frugoli, A., Henson, H., Valdez, V., & Westhoff-Pankratz, T. (2022) · Case Reports in Endocrinology · doi:10.1155/2022/5472304 · Cited by 6 · see citing works
Chen, X., Kamel, D., Barnett, B., Yung, E., Quinn, A., & Nguyen, C. (2018) · Endocrinology, Diabetes & Metabolism Case Reports · doi:10.1530/edm-18-0089 · Cited by 6 · see citing works
Postprandial hypoglycaemia in adults: pathogenesis, diagnosis and management
Sulaiman, R. (2021) · Journal of Laboratory and Precision Medicine · doi:10.21037/jlpm-20-102 · Cited by 5 · see citing works
“Partial pancreatectomy has not been successful in post-bariatric cases, as most patients continue to have symptoms (71).”
BackgroundThen, C., Nam‐Apostolopoulos, Y., Seißler, J., & Lechner, A. (2012) · PubMed · doi:10.6092/1590-8577/1319 · Cited by 5 · see citing works
“In contrast, of 12 patients who ha d undergone subtotal pancreatectomy (more than 90% of the pancreatic tissue), 11 were cured from hypoglycemia, but 75% developed insulin-dependent diabetes mellitus with a high percentage of exocrin e pancreas insufficiency [13, 16, 23], whereas after 50 to 80% pancreatectomy, this w…”
BackgroundInfluentialPost-Gastric Bypass Hypoglycemia: Diagnosis and Management
Fischer, L. E., Belt-Davis, D. I., Khoraki, J., & Campos, G. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-27114-9_21 · Cited by 5 · see citing works
Hypoglycemia - Causes and Occurrences
Cid Rigobelo, E. (2011) · InTech eBooks · doi:10.5772/864 · Cited by 17 · see citing works
Hypoglycemia and Dysautonomia After Bariatric Surgery: a Systematic Review and Perspective
Addison, P., Carsky, K., Patti, M., & Roslin, M. S. (2022) · Obesity Surgery · doi:10.1007/s11695-022-05960-x · Cited by 6 · see citing works
Pancreatogenous Hypoglycemic Syndrome - Insulinoma or Non-Insulinoma Origin (NIPHS)
Lee, C., Ging-Shing, J., & Tseng, H. (2011) · InTech eBooks · doi:10.5772/20973
“, 2006), several lines of evidence—the neuroglycopenic nature of spells, the usual unresponsiveness to dietary modification, and the very high recurrence rate (up to 87%) after gradient-guided pancreatectomy (Vanderveen et al., 2010)—suggest functional as well as structural abnormalities of the disorder.”
BackgroundStill, C., Benotti, P., Hangan, D., & Zubair, F. (2018) · Springer eBooks · doi:10.1007/978-3-319-75841-1_2 · Cited by 3 · see citing works
Hypoglycemia in Pancreatic Disease
Mordes, M. J. T. A. J. P. (2015) · doi:10.3998/panc.2015.11 · Cited by 2 · see citing works
“hypoglycemia attributed to diffuse islet cell disease, 80% had prior history of upper GI surgery (40).”
BackgroundNesidioblastosis in Patients With Severe Postbariatric Hypoglycemia: A Monocentric Case Series
Dawes, D., Trivedi, P., & Lawler, H. M. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf125 · Cited by 1 · see citing works
“A literature review found pancreatectomy resolved hypoglycemia in only 54% of cases, while a survey reported that 90% of patients had recurrence of hypoglycemia [15, 16].”
Medically Refractory Nesidioblastosis as a Late Adverse Effect of Roux-en-Y Gastric Bypass
Ladna, M. (2025) · Cureus · doi:10.7759/cureus.84429 · Cited by 1 · see citing works
“A total of 25% of patients experienced no benefit after pancreatectomy [18].”
Terryn, F.-X., & Majerus, B. (2022) · International Journal of Surgery Case Reports · doi:10.1016/j.ijscr.2022.107271 · Cited by 1 · see citing works
“, at the Mayo Clinic, also showed that 90 % of the patients who underwent partial pancreatectomy for noninsulinoma pancreatogenous hypoglycemia from diffuse islet cell disease have recurrent symptoms and 25 % of them no improvement in quality of life [13].”
BackgroundPostprandial Hyperinsulinemic Hypoglycemia in Bariatric Surgery
de Heide, L. D., Emous, M., & van Beek, A. V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804011-9.00054-6 · Cited by 1 · see citing works
[Nesidioblastosis (diagnosis, surgical treatment)].
Kriger, A., Smirnov, A., Kalinin, D., Glotov, A., Berelavichus, S., Konyaeva, G. I., Lebedeva, A. N., Karel'skaya, N. A., & Tsygankov, V. N. (2015) · Khirurgiia · doi:10.17116/hirurgia20151016-29 · Cited by 1 · see citing works
Teyssandier, S., Rendón, M. E., Lameroli, H., Centurion, B., & Galac, S. (2026) · Topics in Companion Animal Medicine · doi:10.1016/j.tcam.2026.101103
Arafah, O., Nassef, M., Akhtar, A. B., Al-Shammari, H., & Norris, A. (2026) · Saudi Journal of Anaesthesia · doi:10.4103/sja.sja_869_25
“[9,12,13] Male predominance (64.7%, n = 22) mirrors patterns seen in infantile hyperinsulinism, where males are more frequently affected.”
InfluentialTumour-induced hypoglycaemia: a narrative review
Barber, T. M., Bannon, C. A. M., Weickert, M. O., Kyrou, I., & Randeva, H. S. (2021) · Journal of Laboratory and Precision Medicine · doi:10.21037/jlpm-20-110 · Cited by 1 · see citing works
“Although partial pancreatectomy as a treatment option of post-RYGB surgery has had variable results (54-58), a majority of patients appear to have continuation of their hypoglycaemic symptoms post-pancreatectomy, and therefore this surgical option has been abandoned for the purpose of alleviating hypoglycaemia (2).”
BackgroundUN INSOLITO CASO DI IPOGLICEMIA IPERINSULINEMICA DA NESIDIOBLASTOSI E INSULINOMA
Dardano, A., Barone, S., Daniele, G., Kurumthodathu, J. J., Prato, S. D., & Miccoli, R. (2018) · il Diabete · doi:10.30682/ildia1804h
Endurtekin krampaköst hjá ungri konu – sjúkratilfelli
Gunnarsdóttir, G., Guðmundsdóttir, A., Hellman, P., & Stålberg, P. (2016) · Læknablaðið · doi:10.17992/lbl.2016.0708.92
Reactive Hypoglycemia Associated with Mild Adrenal Dysfunction, So-called Adrenal Fatigue
Yamaguchi, H., Kobayashi, A., Shirakami, A., & Hashimoto, N. (2015) · International Journal of Medical and Pharmaceutical Case Reports · doi:10.9734/ijmpcr/2015/12994
“The histologic findings show beta cell hypertrophy with enlarged and hyperchromatic nuclei, and increased periductal islets in the pancreas [31,32].”
BackgroundSerra, F. (2022) · Revista de la Sociedad Española de Cirugía de Obesidad y Metabólica y de la Sociedad Española para el Estudio de la Obesidad · doi:10.53435/funj.00773
“No existe un consenso con respecto al tratamiento quirúrgico de elección (7).”
BackgroundInfluentialRayas, M., & Salehi, M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-v98i10-39a
“When these interventions fail, partial pancreatectomy can be performed in patients with severe neuroglycopenic symptoms (118).”
Background
- Authors
- Vanderveen, K. A., Grant, C. S., Thompson, G. B., Farley, D. R., Richards, M. L., Vella, A., Vollrath, B., & Service, F. J.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Grant, Clive S.
- Venue
- Surgery
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 148
- Issue
- 6
- Pages
- 1237-1246
- ISSN
- 0039-6060 (ISSN-L)
- PMC
- PMC3954513
- OpenAlex
- W2133189846
- Cited by
- 67
- References
- 13
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 4 · 2014: 4 · 2012: 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Surgery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK082396)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Keywords
- partial pancreatectomy, recurrent hypoglycemia, quality of life, fear of hypoglycemia, surgical outcomes
- MeSH terms
- Adolescent, Adult, Aged, Fear, Female, Follow-Up Studies, Health Status, Humans, Hypoglycemia, Islets of Langerhans, Male, Middle Aged, Pancreatectomy, Pancreatic Diseases, Postoperative Complications, Quality of Life, Recurrence, Retrospective Studies, Splenectomy, Time Factors, Treatment Outcome, Treatment Failure
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