A 2019 update on TSH-secreting pituitary adenomas
Abstract
Thyrotropin-secreting pituitary adenomas (TSH-omas) present with signs and symptoms of hyperthyroidism and they are characterized by elevated serum levels of free thyroid hormones with measurable TSH levels. TSH-omas are very infrequent, accounting for less than 1% of all pituitary adenomas, thus representing a very rare cause of hyperthyroidism. For this reason, data collected on these rare disorders are relatively few, but some new researches shed new light on the etiopathogenesis, the diagnosis and the treatment of such a remarkable disease. Since the same biochemical picture is present in the syndromes of thyroid hormone resistance (RTH), in particular in the form of pituitary RTH, failure in distinguishing these clinical entities may lead to improper patient management. Conversely, early diagnosis and correct treatment of TSH-omas may prevent the occurrence of neurological and endocrinological complications, thus leading to a better rate of cure. In the present short review article, the most relevant recent advances in the pathophysiology of TSH-omas are described.
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Treatment for TSH-omas involves neurosurgical intervention.
“Treatment for TSH-omas involves neurosurgical intervention, and corticosteroid therapy is used to treat Addison's disease.69,71,85”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [71]
Addison's disease is treated with corticosteroids.
“Treatment for TSH-omas involves neurosurgical intervention, and corticosteroid therapy is used to treat Addison's disease.69,71,85”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [71]
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- Authors
- Beck-Peccoz, P., Giavoli, C., & Lania, A.
- Affiliations
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Humanitas University (IT)
- Corresponding author
- Lania, A.
- ORCID
- Venue
- Journal of Endocrinological Investigation
- Published
- 2019-06-07
- Volume
- 42
- Issue
- 12
- Pages
- 1401-1406
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- OpenAlex
- W2954800995
- Cited by
- 111
- References
- 44
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 16 · 2023: 27 · 2022: 14 · 2021: 17 · 2020: 12 · 2019: 3
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinological Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- TSH-secreting pituitary adenoma, TSHoma, hyperthyroidism, thyroid hormone resistance, etiopathogenesis, diagnosis, treatment, neurological complications
- MeSH terms
- Adenoma, Humans, Hyperthyroidism, Pituitary Neoplasms, Thyroid Hormones, Thyrotropin
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