Cited by 113Pituitary Gland Disorders and TreatmentsNeuroendocrine Tumor Research AdvancesThyroid Disorders and Treatments

A 2019 update on TSH-secreting pituitary adenomas

Beck-Peccoz, P., Giavoli, C., Lania, A.·2019·Journal of Endocrinological Investigation

Abstract

Thyrotropin-secreting pituitary adenomas (TSH-omas) present with signs and symptoms of hyperthyroidism and they are characterized by elevated serum levels of free thyroid hormones with measurable TSH levels. TSH-omas are very infrequent, accounting for less than 1% of all pituitary adenomas, thus representing a very rare cause of hyperthyroidism. For this reason, data collected on these rare disorders are relatively few, but some new researches shed new light on the etiopathogenesis, the diagnosis and the treatment of such a remarkable disease. Since the same biochemical picture is present in the syndromes of thyroid hormone resistance (RTH), in particular in the form of pituitary RTH, failure in distinguishing these clinical entities may lead to improper patient management. Conversely, early diagnosis and correct treatment of TSH-omas may prevent the occurrence of neurological and endocrinological complications, thus leading to a better rate of cure. In the present short review article, the most relevant recent advances in the pathophysiology of TSH-omas are described.

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Registry

Crossref · 10.1007/s40618-019-01066-x

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Authors
Beck-Peccoz, P., Giavoli, C., & Lania, A.
Affiliations
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
  • Humanitas University (IT)
Corresponding author
Lania, A.
Venue
Journal of Endocrinological Investigation
Published
2019-06-07
Volume
42
Issue
12
Pages
1401-1406
ISSN
  • 0391-4097 (ISSN-L)
  • 1720-8386
OpenAlex
W2954800995
Cited by
111
References
44
Citations by year
2026: 10 · 2025: 12 · 2024: 16 · 2023: 27 · 2022: 14 · 2021: 17 · 2020: 12 · 2019: 3
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Endocrinological Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords
TSH-secreting pituitary adenoma, TSHoma, hyperthyroidism, thyroid hormone resistance, etiopathogenesis, diagnosis, treatment, neurological complications
MeSH terms
Adenoma, Humans, Hyperthyroidism, Pituitary Neoplasms, Thyroid Hormones, Thyrotropin

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