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Cited by 24Birth, Development, and HealthGestational Diabetes Research and ManagementPrenatal Substance Exposure Effects

Sex-dependent associations of maternal androgen levels with offspring BMI and weight trajectory from birth to early childhood

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Huang, G., Aroner, S. A., Bay, C. P., Gilman, S. E., Ghassabian, A., Loucks, E. B., Buka, S. L., Handa, R. J. +3 more·2021·Journal of Endocrinological Investigation
DOI 10.1007/s40618-020-01385-4PMC PMC7873156
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Abstract

Context In preclinical studies, high androgen levels during pregnancy are associated with low birth weight and rapid postnatal weight gain in the offspring. However, human data linking prenatal androgens with birth weight and early life weight gain in the offspring are scarce. Design We evaluated 516 mother-child pairs enrolled in the New England birth cohorts of the Collaborative Perinatal Project (1959-1966). We assayed androgen bioactivity in maternal sera during third-trimester using a receptor-mediated luciferase expression bioassay. Age and sex-specific BMI Z-scores (BMIz), defined using established standards, were assessed at birth, 4 months, 1 year, 4 years, and 7 years. We used linear mixed models to evaluate the relation of maternal androgens with childhood BMIz overall and by sex. We examined the association of maternal androgens with fetal growth restriction. The association of weight trajectories with maternal androgens was examined using multinomial logistic regression. Results Higher maternal androgen levels associated with lower BMIz at birth (β = - 0.39, 95% CI: - 0.73, - 0.06); this relation was sex-dependent, such that maternal androgens significantly associated with BMIz at birth in girls alone (β = - 0.72, 95% CI: - 1.40, - 0.04). The relation of maternal androgens with fetal growth restriction revealed dose threshold effects that differed by sex. There was no significant association between maternal androgens and weight trajectory overall. However, we found a significant sex interaction (p = 0.01); higher maternal androgen levels associated with accelerated catch-up growth in boys (aOR = 2.14, 95% CI: 1.14, 4.03). Conclusion Our findings provide evidence that maternal androgens may have differential effects on the programming of intrauterine growth and postnatal weight gain depending on fetal sex.

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  • Maternal testosterone concentration is negatively correlated with birth weight and BMI in female offspring.

    “Moreover, maternal testosterone concentration has been shown to negatively correlate with birth weight and BMI in female offspring [131].”

    From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [131]

    The Results (page not available) report that higher maternal bioactive androgen levels were associated with lower BMI z-scores at birth in girls; the Discussion links higher androgen levels to fetal growth restriction and lower birth weight. But the Methods show that the study measured bioactive androgens, not testosterone concentration specifically, and the Results found no significant BMI association at later ages. (LLM, conf=0.87)

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Authors
Huang, G., Aroner, S. A., Bay, C. P., Gilman, S. E., Ghassabian, A., Loucks, E. B., Buka, S. L., Handa, R. J., Lasley, B. L., Bhasin, S., & Goldstein, J. M.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
  • National Institutes of Health (US)
  • New York University (US)
  • Brown University (US)
  • University of Arizona College of Medicine- Phoenix (US)
  • University of California, Davis (US)
Corresponding author
Huang, G.
ORCID
Venue
Journal of Endocrinological Investigation
Publisher
Springer Science and Business Media LLC
Published
2020-08-10
Volume
44
Issue
4
Pages
851-863
ISSN
  • 0391-4097 (ISSN-L)
  • 1720-8386
DOI
10.1007/s40618-020-01385-4
PMC
PMC7873156
OpenAlex
W3047983156
Cited by
24
References
4
Citations by year
2026: 4 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 2
FWCI
2.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Endocrinological Investigation (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Heart, Lung, and Blood Institute (K08 HL132122-02)
  • Arizona Biomedical Research Commission (ADHS14-00003606)
  • National Institute of Mental Health (R01MH074679)
  • National Institute on Aging (RC2AG036666, R01AG023397)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
maternal androgens, prenatal androgen exposure, birth weight, childhood BMI, weight trajectories, catch-up growth, fetal growth restriction, sex differences, Collaborative Perinatal Project
MeSH terms
Body-Weight Trajectory, Correlation of Data, Adult, Androgens, Birth Weight, Child, Child Development, Child, Preschool, Female, Humans, Infant, Newborn, Male, New England, Pregnancy, Pregnancy Trimester, Third, Prenatal Care, Sex Factors, Cohort Studies, Weight Gain, Body Mass Index

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