The developmental origins of chronic adult disease
Abstract
Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.
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WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574 · see citing works
Fetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570 · see citing works
Self-citationFetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708 · see citing works
Phenotypic Plasticity and the Origins of Diversity
West-Eberhard, M. J. (1989) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.20.110189.001341 · Cited by 2,110 · see citing works
Fetal origins of adult disease: strength of effects and biological basis
Barker, D., Eriksson, J., Forsén, T., & Osmond, C. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.6.1235 · Cited by 2,024 · see citing works
Compensation for a bad start: grow now, pay later?
Metcalfe, N. B., & Monaghan, P. (2001) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(01)02124-3 · Cited by 1,948 · see citing works
Health consequences of obesity
Reilly, J. J. (2003) · Archives of Disease in Childhood · doi:10.1136/adc.88.9.748 · Cited by 1,652 · see citing works
Calvert, H., Horwich, A., Newlands, E. S., Beǵent, R. H. J., Rustin, G. J. S., Kaye, S. B., Harris, A. L., Williams, C. J., & Slevin, M. L. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92709-2 · Cited by 1,183 · see citing works
Nephron Number in Patients with Primary Hypertension
Keller, G., Zimmer, G., Mall, G., Ritz, E., & Amann, K. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020549 · Cited by 1,102 · see citing works
The role of size at birth and postnatal catch-up growth in determining systolic blood pressure
Huxley, R., Shiell, A. W., & Law, C. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018070-00002 · Cited by 1,046 · see citing works
Bhargava, S. K., Sachdev, H. S., Fall, C. H. D., Osmond, C., Lakshmy, R., Barker, D. J. P., Biswas, S. K. D., Ramji, S., Prabhakaran, D., & Reddy, K. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035698 · Cited by 1,037 · see citing works
Self-citationEarly growth and coronary heart disease in later life: longitudinal study
Eriksson, J. G., Forsén, T., Tuomilehto, J., Osmond, C., & Barker, D. J. P. (2001) · BMJ · doi:10.1136/bmj.322.7292.949 · Cited by 1,004 · see citing works
Early growth and death from cardiovascular disease in women.
Osmond, C., BARKER, D. J. P., Winter, P. D., Fall, C. H. D., & Simmonds, S. J. (1993) · BMJ · doi:10.1136/bmj.307.6918.1519 · Cited by 821 · see citing works
Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976
Rich-Edwards, J. W., Stampfer, M. J., Manson, J. E., ROSNER, B. A., Hankinson, S. E., Colditz, G. A., Hennekens, C. H., & Willett, W. C. (1997) · BMJ · doi:10.1136/bmj.315.7105.396 · Cited by 814 · see citing works
Leon, D. A., Lithell, H. O., Vågerö, D., Koupilová, I., Mohsen, R., Berglund, L., Lithell, U.-B., & McKeigue, P. M. (1998) · BMJ · doi:10.1136/bmj.317.7153.241 · Cited by 807 · see citing works
Kwong, W. Y., Wild, A. E., Roberts, P., Willis, A. C., & Fleming, T. P. (2000) · Development · doi:10.1242/dev.127.19.4195 · Cited by 798 · see citing works
Marmot, M. G., & Wilkinson, R. G. (2001) · BMJ · doi:10.1136/bmj.322.7296.1233 · Cited by 776 · see citing works
Lithell, H., McKeigue, P., Berglund, L., Mohsen, R., Lithell, U., & Leon, D. A. (1996) · BMJ · doi:10.1136/bmj.312.7028.406 · Cited by 716 · see citing works
The Fetal and Childhood Growth of Persons Who Develop Type 2 Diabetes
Forsén, T., Eriksson, J., Tuomilehto, J., Reunanen, A., Osmond, C., & Barker, D. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-3-200008010-00008 · Cited by 715 · see citing works
Huxley, R., Neil, A., & Collins, R. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09834-3 · Cited by 710 · see citing works
McCance, D. R., Pettitt, D. J., Hanson, R. L., Jacobsson, L., Knowler, W. C., & Bennett, P. H. (1994) · BMJ · doi:10.1136/bmj.308.6934.942 · Cited by 690 · see citing works
Birth Weight and Adult Hypertension and Obesity in Women
Curhan, G. C., Chertow, G. M., Willett, W. C., Spiegelman, D. L., Colditz, G. A., Manson, J. E., Speizer, F. E., & Stampfer, M. J. (1996) · Circulation · doi:10.1161/01.cir.94.6.1310 · Cited by 671 · see citing works
Fetal growth and coronary heart disease in South India
Stein, C., Fall, C., Kumaran, K., Osmond, C., Barker, D. J. P., & Cox, V. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04547-3 · Cited by 607 · see citing works
The nutritional basis of the fetal origins of adult disease
Harding, J. E. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.1.15 · Cited by 561 · see citing works
Birthweight and the Risk for Type 2 Diabetes Mellitus in Adult Women
Rich-Edwards, J. W., Colditz, G. A., Stampfer, M. J., Willett, W. C., Gillman, M. W., Hennekens, C. H., Speizer, F. E., & Manson, J. E. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-4_part_1-199902160-00005 · Cited by 544 · see citing works
Birthweight, body-mass index in middle age, and incident coronary heart disease
Frankel, S., Elwood, P. C., Smith, G. D., Sweetnam, P. M., & Yarnell, J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03482-4 · Cited by 507 · see citing works
Forsen, T., Eriksson, J. G., Tuomilehto, J., Osmond, C., & Barker, D. J. P. (1999) · BMJ · doi:10.1136/bmj.319.7222.1403 · Cited by 481 · see citing works
Early adiposity rebound in childhood and risk of Type 2 diabetes in adult life
Eriksson, J. G., Forsén, T., Tuomilehto, J. O., Osmond, C., & Barker, D. J. P. (2003) · Diabetologia · doi:10.1007/s00125-002-1012-5 · Cited by 457 · see citing works
Mother's weight in pregnancy and coronary heart disease in a cohort of finnish men: follow up study
Forsén, T., Eriksson, J. G., Tuomilehto, J. O., Teramo, K., Osmond, C., & Barker, D. J. P. (1997) · BMJ · doi:10.1136/bmj.315.7112.837 · Cited by 452 · see citing works
Is birth weight related to later glucose and insulin metabolism?—a systematic review
Newsome, C., Shiell, A. W., Fall, C. H. D., Phillips, D. I. W., Shier, R., & Law, C. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.00871.x · Cited by 446 · see citing works
Low Birth Weight Predicts Elevated Plasma Cortisol Concentrations in Adults From 3 Populations
Phillips, D. I. W., Walker, B. R., Reynolds, R. M., Flanagan, D., Wood, P. J., Osmond, C., Barker, D. J. P., & Whorwood, C. B. (2000) · Hypertension · doi:10.1161/01.hyp.35.6.1301 · Cited by 389 · see citing works
Lissau, I., Overpeck, M. D., Ruan, W. J., Due, P., Holstein, B. E., & Hediger, M. L. (2004) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.158.1.27 · Cited by 389 · see citing works
BREASTFEEDING IN DEVELOPING COUNTRIES
Villar, J., & Belizán, J. M. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92755-0 · Cited by 375 · see citing works
Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study
Barker, D. J. P., Forsén, T., Uutela, A. K., Osmond, C., & Eriksson, J. G. (2001) · BMJ · doi:10.1136/bmj.323.7324.1273 · Cited by 355 · see citing works
Tracking the development of adiposity from one month of age to adulthood
Rolland‐Cachera, M., Deheeger, M., GUILLOUD-BATAILLE, M., Avons, P., Patois, E., & Sempe, M. (1987) · Annals of Human Biology · doi:10.1080/03014468700008991 · Cited by 353 · see citing works
Eriksson, J. G., Forsén, T., Tuomilehto, J. O., Jaddoe, V. W. V., Osmond, C., & Barker, D. J. (2002) · Diabetologia · doi:10.1007/s00125-001-0757-6 · Cited by 341 · see citing works
A Life Course Approach to Chronic Disease Epidemiology
(1997) · doi:10.1093/oso/9780192627827.001.0001 · Cited by 309 · see citing works
Widdowson, E. M., & McCance, R. A. (1963) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1963.0051 · Cited by 298 · see citing works
McCance, R. A. (1962) · The Lancet · doi:10.1016/s0140-6736(62)90499-3 · Cited by 265 · see citing works
Birth weight: nature or nurture?
Brooks, A. A., Johnson, M. R., Steer, P. J., Pawson, M. E., & Abdalla, H. (1995) · Early Human Development · doi:10.1016/0378-3782(95)01637-i · Cited by 235 · see citing works
Eriksson, J. G., Lindi, V., Uusitupa, M. I. J., Forsén, T., Laakso, M., Osmond, C., & Barker, D. J. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2321 · Cited by 220 · see citing works
Insulin resistance as a programmed response to fetal undernutrition
Phillips, D. I. W. (1996) · Diabetologia · doi:10.1007/bf00400663 · Cited by 214 · see citing works
A Life Course Approach to Chronic Disease Epidemiology
Olsen, J. (1998) · Epidemiology · doi:10.1097/00001648-199809000-00021 · Cited by 187 · see citing works
Growth and living conditions in childhood and hypertension in adult life: a longitudinal study
Barker, D. J. P., Forsén, T., Eriksson, J. G., & Osmond, C. (2002) · Journal of Hypertension · doi:10.1097/00004872-200210000-00013 · Cited by 180 · see citing works
Cellular Development of Some Human Organs Before Birth
Widdowson, E. M., Crabb, D. E., & Milner, R. D. G. (1972) · Archives of Disease in Childhood · doi:10.1136/adc.47.254.652 · Cited by 157 · see citing works
Congenital oligonephropathy: an inborn cause of adult hypertension and progressive renal injury?
Bm, B., & Chertow, G. M. (1993) · PubMed · Cited by 115 · see citing works
McCance, R. A. (1962) · The Lancet · doi:10.1016/s0140-6736(62)92539-4 · Cited by 115 · see citing works
Growth of girls who later develop coronary heart disease
Forsén, T., Osmond, C., Eriksson, J. G., & Barker, D. J. P. (2003) · Heart · doi:10.1136/heart.90.1.20 · Cited by 101 · see citing works
&NA; (1993) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-199309000-00001 · Cited by 79 · see citing works
Ingelfinger, J. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmp020168 · Cited by 72 · see citing works
The midwife, the coincidence, and the hypothesis
Barker, D. J. (2003) · BMJ · doi:10.1136/bmj.327.7429.1428 · Cited by 72 · see citing works
Self-Perpetuating Effects of Birth Size on Blood Pressure Levels in Elderly People
Ylihärsilä, H., Eriksson, J. G., Forsén, T., Kajantie, E., Osmond, C., & Barker, D. J. P. (2003) · Hypertension · doi:10.1161/01.hyp.0000055780.21222.96 · Cited by 59 · see citing works
Lackland, D. T., Egan, B. M., Syddall, H. E., & Barker, D. J. P. (2002) · Hypertension · doi:10.1161/hy0102.100545 · Cited by 51 · see citing works
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Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492 · see citing works
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works
Every Newborn: progress, priorities, and potential beyond survival
Lawn, J. E., Blencowe, H., Oza, S., You, D., Lee, A. C., Waiswa, P., Lalli, M., Bhutta, Z., Barros, A. J., Christian, P., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60496-7 · Cited by 1,929 · see citing works
Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181 · see citing works
More than a feeling: A unified view of stress measurement for population science
Epel, E. S., Crosswell, A. D., Mayer, S. E., Prather, A. A., Slavich, G. M., Puterman, E., & Mendes, W. B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.001 · Cited by 1,077 · see citing works
Bujold, E., Roberge, S., Lacasse, Y., Bureau, M., Audibert, F., Marcoux, S., Forest, J., & Giguère, Y. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181e9322a · Cited by 1,096 · see citing works
Human placenta and trophoblast development: key molecular mechanisms and model systems
Knöfler, M., Haider, S., Saleh, L., Pollheimer, J., Gamage, T. K. J. B., & James, J. L. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03104-6 · Cited by 779 · see citing works
Cnossen, J. S., Morris, R. K., ter Riet, G., Mol, B. W. J., van der Post, J. A. M., Coomarasamy, A., Zwinderman, A. H., Robson, S. C., Bindels, P. J. E., Kleijnen, J., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.070430 · Cited by 719 · see citing works
Genome-wide associations for birth weight and correlations with adult disease
Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J. J., Feenstra, B., van Zuydam, N. R., Gaulton, K. J., Grarup, N., et al. (2016) · Nature · doi:10.1038/nature19806 · Cited by 495 · see citing works
Blake, B. E., & Fenton, S. E. (2020) · Toxicology · doi:10.1016/j.tox.2020.152565 · Cited by 499 · see citing works
Impact of obesity on male fertility, sperm function and molecular composition
Palmer, N. O., Bakos, H. W., Fullston, T., & Lane, M. (2012) · Spermatogenesis · doi:10.4161/spmg.21362 · Cited by 403 · see citing works
Effect of in vitro culture of human embryos on birthweight of newborns
Dumoulin, J. C. M., Land, J. A., van Montfoort, A. P. A., Nelissen, E. C. M., Coonen, E., Derhaag, J. G., Schreurs, I. E. L., Dunselman, G. A. J., Kester, A. D. M., Geraedts, J. P. M., et al. (2010) · Human Reproduction · doi:10.1093/humrep/dep456 · Cited by 359 · see citing works
Maternal Obesity, Metabolism, and Pregnancy Outcomes
King, J. C. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132249 · Cited by 341 · see citing works
Developmental programming of health and disease
Langley‐Evans, S. C. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2005478 · Cited by 338 · see citing works
Preterm Birth and Body Composition at Term Equivalent Age: A Systematic Review and Meta-analysis
Johnson, M. J., Wootton, S. A., Leaf, A., & Jackson, A. A. (2012) · PEDIATRICS · doi:10.1542/peds.2011-3379 · Cited by 317 · see citing works
Landrigan, P. J., & Goldman, L. R. (2011) · Health Affairs · doi:10.1377/hlthaff.2011.0151 · Cited by 303 · see citing works
Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study
Jornayvaz, F. R., Vollenweider, P., Bochud, M., Mooser, V., Waeber, G., & Marques-Vidal, P. M. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0389-2 · Cited by 298 · see citing works
Delahaye, F., Breton, C., Risold, P., Enache, M., Dutriez-Casteloot, I., Laborie, C., Lésage, J., & Vieau, D. (2007) · Endocrinology · doi:10.1210/en.2007-1263 · Cited by 266 · see citing works
The role of nutrition on epigenetic modifications and their implications on health
Jiménez-Chillarón, J. C., Díaz, R., Martínez, D., Pentinat, T., Ramón-Krauel, M., Ribó, S., & Plösch, T. (2012) · Biochimie · doi:10.1016/j.biochi.2012.06.012 · Cited by 266 · see citing works
Blake, B., Cope, H. A., Hall, S. M., Keys, R. D., Mahler, B., McCord, J. P., Scott, B. E., Stapleton, H., Strynar, M., Elmore, S., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6233 · Cited by 201 · see citing works
Early-Life Risk Factors for Alzheimer Disease
Borenstein, A. R., Copenhaver, C. I., & Mortimer, J. A. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000201854.62116.d7 · Cited by 259 · see citing works
Hagadorn, J. I., Furey, A., Nghiem‐Rao, T. H., Schmid, C. H., Phelps, D. L., Pillers, D. M., Cole, C. H., & and the AVIOx Study Group (2006) · PEDIATRICS · doi:10.1542/peds.2005-0413 · Cited by 257 · see citing works
de Rooij, S. R., Painter, R. C., Roseboom, T. J., Phillips, D. I. W., Osmond, C., Barker, D. J. P., Tanck, M. W. T., Michels, R. P. J., Bossuyt, P. M., & Bleker, O. P. (2006) · Diabetologia · doi:10.1007/s00125-005-0136-9 · Cited by 237 · see citing works
Loomans, E. M., van Dijk, A. E., Vrijkotte, T. G. M., van Eijsden, M., Stronks, K., Gemke, R. J. B. J., & Van den Bergh, B. R. H. (2013) · European Journal of Public Health · doi:10.1093/eurpub/cks097 · Cited by 212 · see citing works
Castellano, J. M., Overgaard, A., Sanchez-Garrido, M. A., Ruíz-Pino, F., Romero, M., García-Galiano, D., Aguilar, E., Pinilla, L., Diéguez, C., Mikkelsen, J. D., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1415 · Cited by 206 · see citing works
Guidelines for Implementing Culturally Competent Nursing Care
Douglas, M. K., Rosenkoetter, M. M., Pacquiao, D. F., Callister, L. C., Hattar‐Pollara, M., Lauderdale, J. L., Milstead, J. A., Nardi, D. A., & Purnell, L. D. (2014) · Journal of Transcultural Nursing · doi:10.1177/1043659614520998 · Cited by 204 · see citing works
Holmes, M. C., Abrahamsen, C. T., French, K. L., Paterson, J. M., Mullins, J. J., & Seckl, J. R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4464-05.2006 · Cited by 200 · see citing works
Bakulski, K., Rozek, L., Dolinoy, D., Paulson, H., & Hu, H. (2012) · Current Alzheimer Research · doi:10.2174/156720512800617991 · Cited by 193 · see citing works
Sharp, A., Cornforth, C., Jackson, R., Harrold, J. A., Turner, M. A., Kenny, L. C., Baker, P. N., Johnstone, E., Khalil, A. A., von Dadelszen, P., et al. (2017) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(17)30173-6 · Cited by 196 · see citing works
Long-term influence of normal variation in neonatal characteristics on human brain development
Walhovd, K. B., Fjell, A. M., Brown, T. T., Kuperman, J. M., Chung, Y., Hagler, D. J., Roddey, J. C., Erhart, M., McCabe, C., Akshoomoff, N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208180109 · Cited by 187 · see citing works
Nandi, A. A., Chen, Z., Patel, R., & Poretsky, L. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.10.003 · Cited by 189 · see citing works
Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants
Stanislawski, M. A., Dabelea, D., Wagner, B. D., Sontag, M. K., Lozupone, C., & Eggesbø, M. Å. (2017) · Microbiome · doi:10.1186/s40168-017-0332-0 · Cited by 181 · see citing works
Role of the hypothalamic–pituitary–adrenal axis in developmental programming of health and disease
Xiong, F., & Zhang, L. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.11.002 · Cited by 177 · see citing works
PUFAs in Fish: Extraction, Fractionation, Importance in Health
Sahena, F., Zaidul, I. S. M., Jinap, S., Saari, N., Jahurul, M. H. A., Abbas, K. A., & Rahman, N. N. N. A. (2009) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2009.00069.x · Cited by 176 · see citing works
Gill, J. M. R., & Malkova, D. (2006) · Clinical Science · doi:10.1042/cs20050207 · Cited by 170 · see citing works
The Role of Microbes in Developmental Immunologic Programming
Kaplan, J. L., Shi, H. N., & Walker, W. A. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318217638a · Cited by 169 · see citing works
Epigenome Mapping in Normal and Disease States
Maunakea, A. K., Chepelev, I., & Zhao, K. (2010) · Circulation Research · doi:10.1161/circresaha.110.222463 · Cited by 163 · see citing works
Guo, L., Choufani, S., Ferreira, J. C., Smith, A. C., Chitayat, D. A., Shuman, C. T., Uxa, R., Keating, S. J., Kingdom, J. C., & Weksberg, R. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.025 · Cited by 164 · see citing works
Epigenetic Transgenerational Inheritance of Obesity Susceptibility
King, S. E., & Skinner, M. K. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.02.009 · Cited by 164 · see citing works
Childhood obesity and cardiovascular disease
Bridger, T. (2009) · Paediatrics & Child Health · doi:10.1093/pch/14.3.177 · Cited by 163 · see citing works
Schlotz, W., Jones, A., Phillips, D. I. W., Gale, C. R., Robinson, S. M., & Godfrey, K. M. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02182.x · Cited by 165 · see citing works
The role of microorganisms in achieving the sustainable development goals
Akinsemolu, A. A. (2018) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2018.02.081 · Cited by 160 · see citing works
Epigenetic Regulation of Human Trophoblastic Cell Migration and Invasion
Rahnama, F., Shafiei, F., Gluckman, P. D., Mitchell, M. D., & Lobie, P. E. (2006) · Endocrinology · doi:10.1210/en.2006-0288 · Cited by 160 · see citing works
Environmental epigenetic inheritance through gametes and implications for human reproduction
Wei, Y., Schatten, H., & Sun, Q. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu061 · Cited by 157 · see citing works
de Waal, E., Vrooman, L. A., Fischer, E., Ord, T. S., Mainigi, M. A., Coutifaris, C., Schultz, R. M., & Bartolomei, M. S. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv400 · Cited by 157 · see citing works
Oluwasanmi, J. O. (1974) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)32271-9 · Cited by 157 · see citing works
Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis
Słabuszewska-Jóźwiak, A., Szymański, J. K., Ciebiera, M., Sarecka‐Hujar, B., & Jakiel, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218031 · Cited by 162 · see citing works
Gene expression in the placenta: maternal stress and epigenetic responses
Gheorghe, C. P., Goyal, R., Mittal, A., & Longo, L. D. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082770cg · Cited by 150 · see citing works
Chapter 5 Biomarkers Related To Aging In Human Populations
Crimmins, E. M., Vasunilashorn, S. M., Kim, J. K., & Alley, D. E. (2008) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)00405-8 · Cited by 156 · see citing works
A second look at the influence of birth weight on carcass and meat quality in pigs
Rehfeldt, C., Tuchscherer, A., Hartung, M., & Kuhn, G. (2007) · Meat Science · doi:10.1016/j.meatsci.2007.05.029 · Cited by 151 · see citing works
Lung-function trajectories: relevance and implementation in clinical practice
Melén, E., Faner, R., Allinson, J. P., Bui, D., Bush, A., Čustović, A., García‐Aymerich, J., Guerra, S., Breyer‐Kohansal, R., Hallberg, J., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00016-3 · Cited by 145 · see citing works
Roche, J. R., Blache, D., Kay, J. K., Miller, D. R., Sheahan, A. J., & Miller, D. W. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138744 · Cited by 139 · see citing works
Human Milk and Allergic Diseases: An Unsolved Puzzle
Munblit, D., Peroni, D. G., Boix-Amorós, A., Hsu, P. S., Land, B. V., Gay, M. C. L., Kolotilina, A., Skevaki, C. L., Boyle, R. J., Collado, M. C., et al. (2017) · Nutrients · doi:10.3390/nu9080894 · Cited by 159 · see citing works
Ślusarczyk, J., Trojan, E., Głombik, K., Budziszewska, B., Kubera, M., Lasoń, W., Popiołek-Barczyk, K., Mika, J., Wędzony, K., & Basta‐Kaim, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00082 · Cited by 135 · see citing works
Li, Y., Ley, S. H., Tobias, D. K., Chiuve, S. E., VanderWeele, T. J., Rich-Edwards, J. W., Curhan, G. C., Willett, W. C., Manson, J. E., Hu, F. B., et al. (2015) · BMJ · doi:10.1136/bmj.h3672 · Cited by 134 · see citing works
Lane, M., McPherson, N. O., Fullston, T., Spillane, M., Sandeman, L., Kang, W. X., & Zander‐Fox, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100832 · Cited by 132 · see citing works
Early life programming as a target for prevention of child and adolescent mental disorders
Lewis, A. J., Galbally, M., Gannon, T., & Symeonides, C. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-33 · Cited by 133 · see citing works
Effect of Maternal Cardiovascular Conditions and Risk Factors on Offspring Cardiovascular Disease
Palinski, W. (2014) · Circulation · doi:10.1161/circulationaha.113.001805 · Cited by 130 · see citing works
Regulation of Placental Amino Acid Transport and Fetal Growth
Vaughan, O. R., Rosario, F. J., Powell, T. L., & Jansson, T. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.008 · Cited by 130 · see citing works
Can We Modify the Intrauterine Environment to Halt the Intergenerational Cycle of Obesity?
Adamo, K. B., Ferraro, Z. M., & Brett, K. (2012) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph9041263 · Cited by 128 · see citing works
Fjell, A., Westlye, L., Amlien, I., Tamnes, C., Grydeland, H., Engvig, A., Espeseth, T., Reinvang, I., Lundervold, A., Lundervold, A., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht201 · Cited by 121 · see citing works
Bergvall, N., Iliadou, A. N., Johansson, S., Fairé, U. D., Kramer, M. S., Yudi Pawitan, Y., Pedersen, N. L., Lichtenstein, P., & Cnattingius, S. (2007) · Circulation · doi:10.1161/circulationaha.106.674812 · Cited by 126 · see citing works
Complementary Foods and Flavor Experiences: Setting the Foundation
Mennella, J. A., & Trabulsi, J. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000335337 · Cited by 127 · see citing works
Morris, R. K., Cnossen, J. S., Langejans, M., Robson, S. C., Kleijnen, J., ter Riet, G., Mol, B. W., van der Post, J., & Khan, K. S. (2008) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-8-33 · Cited by 124 · see citing works
Ali, Z., Saaka, M., Adams, A.-G., Kamwininaang, S. K., & Abizari, A. (2017) · BMC Nutrition · doi:10.1186/s40795-017-0154-2 · Cited by 123 · see citing works
Nutritional manipulations in the perinatal period program adipose tissue in offspring
Lukaszewski, M., Eberlé, D., Vieau, D., & Breton, C. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00231.2013 · Cited by 122 · see citing works
Infant regulation of intake: the effect of free glutamate content in infant formulas
Ventura, A. K., Beauchamp, G. K., & Mennella, J. A. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.024919 · Cited by 122 · see citing works
Maternal exercise improves insulin sensitivity in mature rat offspring
CARTER, L. G., QI, N. R., CABO, R. D., & PEARSON, K. J. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31827de953 · Cited by 121 · see citing works
Mäkelä, J., Linderborg, K. M., Niinikoski, H., Yang, B., & Lagström, H. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0378-5 · Cited by 120 · see citing works
HPA axis programming by maternal undernutrition in the male rat offspring
Vieau, D., Sebaai, N., Léonhardt, M., Dutriez-Casteloot, I., Molendi‐Coste, O., Laborie, C., Breton, C., DELOOF, S., & Lésage, J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.014 · Cited by 117 · see citing works
Peri-conception parental obesity, reproductive health, and transgenerational impacts
Lane, M., Zander‐Fox, D., Robker, R. L., & McPherson, N. O. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.11.005 · Cited by 117 · see citing works
Kazemier, B. M., Buijs, P. E., Mignini, L. E., Limpens, J., de Groot, C. J. M., Mol, B. W., & CONNECT, E. (2014) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12896 · Cited by 116 · see citing works
Standards of Practice for Culturally Competent Nursing Care
Douglas, M. K., Pierce, J. U., Rosenkoetter, M. M., Pacquiao, D. F., Callister, L. C., Hattar‐Pollara, M., Lauderdale, J. L., Milstead, J. A., Nardi, D. A., & Purnell, L. D. (2011) · Journal of Transcultural Nursing · doi:10.1177/1043659611412965 · Cited by 115 · see citing works
Booij, L., Wang, D., Lévesque, M. L., Tremblay, R. E., & Szyf, M. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0251 · Cited by 114 · see citing works
Tan, J. M., Loganath, A., Chong, Y. S., & Obbard, J. P. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.09.045 · Cited by 115 · see citing works
Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea
Polychronaki, N., Wild, C. P., Mykkänen, H. M., Amra, H., Abdel-Wahhab, M. A., Sylla, A., Diallo, M. S., El-Nezami, H. S., & Turner, P. C. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.08.034 · Cited by 113 · see citing works
Paradis, A. N., Gay, M. S., & Zhang, L. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.10.019 · Cited by 111 · see citing works
A longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers
Polychronaki, N., West, R. M., Turner, P. C., Amra, H., Abdel-Wahhab, M. A., Mykkänen, H. M., & El-Nezami, H. S. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.01.001 · Cited by 110 · see citing works
The Association of Maternal Age with Birthweight and Gestational Age: A Cross‐Cohort Comparison
Restrepo–Méndez, M. C., Lawlor, D. A., Horta, B. L., Matijasevich, A., Santos, I. S., Menezes, A. M. B., Barros, F. C., & Victora, C. G. (2014) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12162 · Cited by 105 · see citing works
SOCIOECONOMIC STATUS AND ADVERSE BIRTH OUTCOMES: A POPULATION-BASED CANADIAN SAMPLE
Campbell, E. E., Gilliland, J., Dworatzek, P. D. N., de Vrijer, B., Penava, D., & Seabrook, J. A. (2017) · Journal of Biosocial Science · doi:10.1017/s0021932017000062 · Cited by 106 · see citing works
Nomura, Y., WICKRAMARATNE, P. J., Pilowsky, D. J., Newcorn, J. H., Bruder-Costello, B., Davey, C., Fifer, W. P., Jeanne Brooks-gunn, B., & Weissman, M. M. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2007.04.005 · Cited by 103 · see citing works
Breton, C., Lukaszewski, M., Risold, P., Enache, M., Guillemot, J., Rivière, G., Delahaye, F., Lésage, J., Dutriez-Casteloot, I., Laborie, C., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90740.2008 · Cited by 102 · see citing works
Şanlı, E., & Kabaran, S. (2019) · Current Genomics · doi:10.2174/1389202920666191030092225 · Cited by 104 · see citing works
Coan, P. M., Ferguson‐Smith, A. C., & Burton, G. J. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00488.x · Cited by 94 · see citing works
The Interplay between DNA Methylation, Folate and Neurocognitive Development
Irwin, R. E., Pentieva, K. D., Cassidy, T., Lees‐Murdock, D. J., McLaughlin, M., Prasad, G., McNulty, H., & Walsh, C. P. (2016) · Epigenomics · doi:10.2217/epi-2016-0003 · Cited by 94 · see citing works
Burggren, W. W., & Reyna, K. S. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.05.001 · Cited by 94 · see citing works
The developmental origins of adult disease
Joss‐Moore, L. A., & Lane, R. H. (2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328326773b · Cited by 93 · see citing works
Briana, D. D., & Malamitsi‐Puchner, A. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.019 · Cited by 91 · see citing works
Early immunological development and mortality from infectious disease in later life
Moore, S. E., Collinson, A. C., N’Gom, P. T., Aspinall, R., & Prentice, A. M. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2006503 · Cited by 90 · see citing works
Franco, J. G., Lisboa, P. C., Lima, N. S., Amaral, T. A. S., Peixoto‐Silva, N., Resende, Â. C., OLIVEIRA, E. B. D., Passos, M. C. F., & de Moura, E. G. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.019 · Cited by 89 · see citing works
Morris, R. K., Malin, G. L., Robson, S. C., Kleijnen, J., Zamora, J., & Khan, K. S. (2010) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7767 · Cited by 89 · see citing works
Ahmed, S. M., Hadi, A., Razzaque, A., Ashraf, A., Juvekar, S. K., Ng, N., Kanungsukkasem, U., Soonthornthada, K., Minh, H. V., & Bich, T. H. (2009) · Global Health Action · doi:10.3402/gha.v2i0.1986 · Cited by 89 · see citing works
Guo, P., Chen, Y., Wu, H., Zeng, J., Zeng, Z., Li, W., Zhang, Q., Huo, X., Feng, W., Lin, J., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.105410 · Cited by 87 · see citing works
Cardiovascular Health Among Pregnant Women, Aged 20 to 44 Years, in the United States
Perak, A. M., Ning, H., Khan, S. S., Horn, L. V., Grobman, W. A., & Lloyd‐Jones, D. M. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015123 · Cited by 86 · see citing works
Robinson, D. L., Cafe, L. M., & Greenwood, P. L. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5799 · Cited by 85 · see citing works
Aaltonen, J., Ojala, T. H., Laitinen, K., Poussa, T. A., Ozanne, S. E., & Isolauri, E. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.225 · Cited by 85 · see citing works
Predictors of low birth weight and preterm birth in rural Uganda: Findings from a birth cohort study
Bater, J., Lauer, J. M., Ghosh, S. A., Webb, P., Agaba, E., Bashaasha, B., Turyashemererwa, F., Shrestha, R., & Duggan, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235626 · Cited by 84 · see citing works
Wemakor, A., & Mensah, K. A. (2016) · BMC Public Health · doi:10.1186/s12889-016-3558-z · Cited by 82 · see citing works
Peng, S., Deyssenroth, M. A., Narzo, A. F. D., Cheng, H. M., Zhang, Z., Lambertini, L., Ruusalepp, A., Kovacic, J. C., Björkegren, J., Marsit, C. J., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007799 · Cited by 80 · see citing works
Climate Change, Food Supply, and Dietary Guidelines
Binns, C. W., Lee, M. K., Maycock, B. R., Torheim, L. E., Nanishi, K., & Duong, D. T. T. (2021) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-012420-105044 · Cited by 84 · see citing works
- Authors
- Barker, D.
- Affiliations
- Southampton General Hospital (GB)
- Corresponding author
- Barker, DJP
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2004-11
- Volume
- 93
- Issue
- s446
- Pages
- 26-33
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2143230895
- Cited by
- 790
- References
- 53
- Citations by year
- 2026: 19 · 2025: 38 · 2024: 49 · 2023: 42 · 2022: 36 · 2021: 63 · 2020: 55 · 2019: 42 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 40 · 2014: 37 · 2013: 40 · 2012: 45
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- developmental origins of health and disease, low birth weight, coronary artery disease, stroke, hypertension, type 2 diabetes, developmental plasticity, fetal growth restriction, gestational age, child weight gain, environmental influences on development
- MeSH terms
- Adult, Birth Weight, Cardiovascular Diseases, Child, Child Development, Child, Preschool, Chronic Disease, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant, Newborn, Male
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