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Cited by 25

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Thyroid function in the subacute phase of traumatic brain injury: a potential predictor of post-traumatic neurological and functional outcomes

Mele, C., Pagano, L., Franciotta, D., Caputo, M., Nardone, A., Aimaretti, G., Marzullo, P., Pingue, V.·2022·Journal of Endocrinological Investigation
DOI 10.1007/s40618-021-01656-8
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Abstract

Purpose: That thyroid hormones exert pleiotropic effects and have a contributory role in triggering seizures in patients with traumatic brain injury (TBI) can be hypothesized. We aimed at investigating thyroid function tests as prognostic factors of the development of seizures and of functional outcome in TBI. Methods: This retrospective study enrolled 243 adult patients with a diagnosis of mild-to-severe TBI, consecutively admitted to our rehabilitation unit for a 6-month neurorehabilitation program. Data on occurrence of seizures, brain imaging, injury characteristics, associated neurosurgical procedures, neurologic and functional assessments, and death during hospitalization were collected at baseline, during the workup and on discharge. Thyroid function tests (serum TSH, fT4, and fT3 levels) were performed upon admission to neurorehabilitation. Results: Serum fT3 levels were positively associated with an increased risk of late post-traumatic seizures (LPTS) in post-TBI patients independent of age, sex and TBI severity (OR = 1.85, CI 95% 1.22–2.61, p < 0.01). Measured at admission, fT3 values higher than 2.76 pg/mL discriminated patients with late post-traumatic seizures from those without, with a sensitivity of 74.2% and a specificity of 60.9%. Independently from the presence of post-traumatic epilepsy and TBI severity, increasing TSH levels and decreasing fT3 levels were associated with worse neurological and functional outcome, as well as with higher risk of mortality within 6 months from the TBI event. Conclusions: Serum fT3 levels assessed in the subacute phase post-TBI are associated with neurological and functional outcome as well as with the risk of seizure occurrence. Further studies are needed to investigate the mechanisms underlying these associations.

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Cited by

Metadata

Authors
Mele, C., Pagano, L., Franciotta, D., Caputo, M., Nardone, A., Aimaretti, G., Marzullo, P., & Pingue, V.
ORCID
Mele, C.
Venue
Journal of Endocrinological Investigation
Publisher
Springer Science and Business Media LLC
Published
2021-08-05
Volume
45
Issue
2
Pages
379-389
ISSN
1720-8386
DOI
10.1007/s40618-021-01656-8
Cited by
25
References
5
Language
en
Licence
Funders
Università degli Studi di Pavia

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