Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works

Traumatic brain injury in the United States : emergency department visits, hospitalizations, and deaths, 2002-2006

National Center for Injury Prevention and Control (U.S.). Division of Injury Response., Faul, M., Wald, M. M., Wu, L., & Coronado, V. G. (2010) · doi:10.15620/cdc.5571 · Cited by 3,494 · see citing works

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works

Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths

Langlois, J., Rutland-Brown, W., & Thomas, K. (2006) · PsycEXTRA Dataset · doi:10.1037/e721222007-001 · Cited by 3,003 · see citing works

The blood-brain barrier/neurovascular unit in health and disease

Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works

Traumatic brain injury

Ghajar, J. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02689-1 · Cited by 2,244 · see citing works

Moderate and severe traumatic brain injury in adults

Maas, A. I., Stocchetti, N., & Bullock, R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70164-9 · Cited by 2,123 · see citing works

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

Faden, A. I., Demediuk, P., Panter, S. S., & Vink, R. (1989) · Science · doi:10.1126/science.2567056 · Cited by 1,508 · see citing works

Measurement of the blood‐brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts

Tofts, P. S., & Kermode, A. G. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910170208 · Cited by 1,458 · see citing works

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426 · see citing works

Long-term potentiation depends on release of d-serine from astrocytes

Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389 · see citing works

Untitled work

(1999) · doi:10.1097/00001199-199912000-00009 · Cited by 1,387 · see citing works

The role of inflammation in CNS injury and disease

Lucas, S., Rothwell, N. J., & Gibson, R. M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706400 · Cited by 1,272 · see citing works

Classification of traumatic brain injury for targeted therapies

Saatman, K. E., Duhaime, A.-C., Bullock, R., Maas, A. I. R., Valadka, A., & Manley, G. T. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2008.0586 · Cited by 1,141 · see citing works

Cytokines and acute neurodegeneration

Allan, S. M., & Rothwell, N. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094583 · Cited by 1,126 · see citing works

A population-based study of seizures after traumatic brain injuries

Annegers, J. F., Hauser, W. A., Coan, S. P., & Rocca, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801013380104 · Cited by 1,090 · see citing works

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat

Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060 · see citing works

Brain Inflammation in Epilepsy: Experimental and Clinical Evidence

Vezzani, A., & Granata, T. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00298.x · Cited by 1,038 · see citing works

Interleukin-1 and neuronal injury

Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992 · see citing works

A Randomized, Double-Blind Study of Phenytoin for the Prevention of Post-Traumatic Seizures

Temkin, N. R., DIKMEN, S. S., Wilensky, A. J., Keihm, J., Chabal, S., & Winn, H. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230801 · Cited by 990 · see citing works

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

Meyer-Luehmann, M., Spires-Jones, T. L., Prada, C., Garcia-Alloza, M., de Calignon, A., Rozkalne, A., Koenigsknecht-Talboo, J., Holtzman, D. M., Bacskai, B. J., & Hyman, B. T. (2008) · Nature · doi:10.1038/nature06616 · Cited by 987 · see citing works

The Incidence and Economic Burden of Injuries in the United States

Finkelstein, E. A., Corso, P. S., & Miller, T. R. (2006) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195179484.001.0001 · Cited by 936 · see citing works

Clinical trials in head injury

Narayan, R. K., Michel, M. E., Ansell, B., Baethmann, A., Biegon, A., Bracken, M. B., Bullock, M. R., Choi, S. C., Clifton, G. L., Contant, C. F., et al. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753754037 · Cited by 913 · see citing works

Edema and brain trauma

Unterberg, A. W., Stover, J., Kress, B., & Kiening, K. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.046 · Cited by 881 · see citing works

Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases

Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M. M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C. L., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08692.2003 · Cited by 876 · see citing works

An astrocytic basis of epilepsy

Tian, G.-F., Azmi, H., Takano, T., Xu, Q., Peng, W., Lin, J., Oberheim, N., Lou, N., Wang, X., Zielke, H. R., et al. (2005) · Nature Medicine · doi:10.1038/nm1277 · Cited by 806 · see citing works

Astrocyte dysfunction in neurological disorders: a molecular perspective

Seifert, G., Schilling, K., & Steinhäuser, C. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1870 · Cited by 798 · see citing works

Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy

van Vliet, E. A., da Costa Araujo, S., Redeker, S., van Schaik, R., Aronica, E., & Gorter, J. A. (2007) · Brain · doi:10.1093/brain/awl318 · Cited by 775 · see citing works

Role of matrix metalloproteinases in delayed cortical responses after stroke

Zhao, B., Wang, S. Y., Kim, H.-Y., Storrie, H., Rosen, B. R., Mooney, D. J., Wang, X., & Lo, E. H. (2006) · Nature Medicine · doi:10.1038/nm1387 · Cited by 704 · see citing works

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

Cirrito, J. R., Kang, J.-E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., Bu, G., Mennerick, S., & Holtzman, D. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.003 · Cited by 635 · see citing works

Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury

Yakovlev, A. G., Knoblach, S. M., Fan, L., Fox, G. B., Goodnight, R., & Faden, A. I. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07415.1997 · Cited by 575 · see citing works

EBIC-Guidelines for management of severe head injury in adults

Maas, A. I. R., Dearden, M., Teasdale, G. M., Braakman, R., Cohadon, F., Iannotti, F., Karimi, A., Lapierre, F., Murray, G. D., Öhman, J. E., et al. (1997) · Acta Neurochirurgica · doi:10.1007/bf01808823 · Cited by 572 · see citing works

TGF- receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis

Ivens, S., Kaufer, D., Flores, L. P., Bechmann, I., Zumsteg, D., Tomkins, O., Seiffert, E., Heinemann, U., & Friedman, A. (2007) · Brain · doi:10.1093/brain/awl317 · Cited by 567 · see citing works

The role of cytokines in the pathophysiology of epilepsy

Vezzani, A., Balosso, S., & Ravizza, T. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.03.009 · Cited by 558 · see citing works

Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography

Bouma, G. J., Muizelaar, J. P., Stringer, W. A., et al. (1992) · Journal of neurosurgery · doi:10.3171/jns.1992.77.3.0360 · Cited by 556 · see citing works

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

Rink, A. D., Fung, K., Trojanowski, J. Q., Lee, V. M.-Y., Neugebauer, E. A. M., & McIntosh, T. K. (1995) · Europe PMC (PubMed Central) · Cited by 521 · see citing works

RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease

Donahue, J. E., Flaherty, S. L., Johanson, C. E., Duncan, J. A., Silverberg, G. D., Miller, M. C., Tavares, R., Yang, W., Wu, Q., Sabo, E., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0115-3 · Cited by 519 · see citing works

Lasting Blood-Brain Barrier Disruption Induces Epileptic Focus in the Rat Somatosensory Cortex

Seiffert, E., Dreier, J. P., Ivens, S., Bechmann, I., Tomkins‐Netzer, O., Heinemann, U., & Friedman, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1751-04.2004 · Cited by 518 · see citing works

Cortical spreading depression activates and upregulates MMP-9

Özdemir, Y., Qiu, J., Matsuoka, N., Bolay, H., Bermpohl, D., Jin, H., Wang, X., Rosenberg, G. A., Lo, E. H., & Moskowitz, M. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21227 · Cited by 512 · see citing works

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

Fabene, P. F., Mora, G. N., Martinello, M., Rossi, B., Merigo, F., Ottoboni, L., Bach, S., Angiari, S., Benati, D., Chakir, A., et al. (2008) · Nature Medicine · doi:10.1038/nm.1878 · Cited by 509 · see citing works

Seizure‐Promoting Effect of Blood–Brain Barrier Disruption

Marchi, N., Angelov, L., Masaryk, T., Fazio, V. J., Granata, T., Hernandez, N., Hallene, K. L., Diglaw, T., Franic, L. A., Najm, I., et al. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.00988.x · Cited by 508 · see citing works

Head injury and the risk of AD in the MIRAGE study

Guo, Z., Cupples, L. A., Kurz, A., Auerbach, S. H., Volicer, L., Chui, H., Green, R. C., Sadovnick, A. D., Duara, R., DeCarli, C., et al. (2000) · Neurology · doi:10.1212/wnl.54.6.1316 · Cited by 506 · see citing works

Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography.

Smith, D. S. (1993) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-199301000-00013 · Cited by 467 · see citing works

Animal models of head trauma

Cernak, I. (2005) · NeuroRX · doi:10.1602/neurorx.2.3.410 · Cited by 462 · see citing works

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

van Bruggen, N., Thibodeaux, H., Palmer, J. T., Lee, W. P., Fu, L., Cairns, B., Tumas, D. B., Gerlai, R. T., Williams, S., Campagne, M. V. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8218 · Cited by 457 · see citing works

Epilepsy after brain insult

Herman, S. T. (2002) · Neurology · doi:10.1212/wnl.59.9_suppl_5.s21 · Cited by 433 · see citing works

Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy

Rigau, V., Morin, M., Rousset, M.-C., de Bock, F., Lebrun, A., Coubes, P., Picot, M.-C., Baldy-Moulinier, M., Bockaert, J., Crespel, A., et al. (2007) · Brain · doi:10.1093/brain/awm118 · Cited by 429 · see citing works

Clearance of amyloid-β by circulating lipoprotein receptors

Sagare, A. P., Deane, R., Bell, R. D., Johnson, B., Hamm, K., Pendu, R., Marky, A. H., Lenting, P. J., Wu, Z., Zarcone, T. J., et al. (2007) · Nature Medicine · doi:10.1038/nm1635 · Cited by 428 · see citing works

The Duality of the Inflammatory Response to Traumatic Brain Injury

McIntosh, T. K., Lenzlinger, P. M., Morganti-Kossmann, M. C., & Laurer, H. L. (2001) · Molecular Neurobiology · doi:10.1385/mn:24:1-3:169 · Cited by 424 · see citing works

Modulation of immune response by head injury

Morganti-Kossmann, M. C., Satgunaseelan, L., Bye, N., & Kossmann, T. (2007) · Injury · doi:10.1016/j.injury.2007.10.005 · Cited by 412 · see citing works

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury

Ikonomovic, M. D., Uryu, K., Abrahamson, E. E., Ciallella, J. R., Trojanowski, J. Q., Lee, V. M.-Y., Clark, R. S., Marion, D. W., Wisniewski, S. R., & DeKosky, S. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.011 · Cited by 399 · see citing works

Astrocytes in the Epileptic Brain

Wetherington, J. P., Serrano, G. E., & Dingledine, R. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.002 · Cited by 391 · see citing works

The Blood–Brain Barrier and Epilepsy

Oby, E. R., & Janigro, D. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00817.x · Cited by 389 · see citing works

Transcriptome Profiling Reveals TGF- Signaling Involvement in Epileptogenesis

Cacheaux, L. P., Ivens, S., David, Y. B., Lakhter, A. J., Bar‐Klein, G., Shapira, M., Heinemann, U., Friedman, A., & Kaufer, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0430-09.2009 · Cited by 385 · see citing works

Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

Giovanni, S. D., Movsesyan, V. A., Ahmed, F. A. K. M., Černak, I., Schinelli, S., Stoica, B. A., & Faden, A. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500989102 · Cited by 380 · see citing works

Guidelines for Prehospital Management of Traumatic Brain Injury 2nd Edition

Badjatia, N., Carney, N., Crocco, T. J., Fallat, M. E., HENNES, H. M., Jagoda, A., Jernigan, S. C., Letarte, P. B., Lerner, E. B., Moriarty, T. M., et al. (2008) · Prehospital Emergency Care · doi:10.1080/10903120701732052 · Cited by 368 · see citing works

Prognosis and Clinical Trial Design in Traumatic Brain Injury: The IMPACT Study

Maas, A., Marmarou, A., Murray, G., Teasdale, G., & Steyerberg, E. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0024 · Cited by 366 · see citing works

Junctional complexes of the blood–brain barrier: permeability changes in neuroinflammation

Petty, M. A., & Lo, E. H. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00128-4 · Cited by 361 · see citing works

Experimental models of traumatic brain injury: do we really need to build a better mousetrap?

Morales, D. M., Marklund, N., Lebold, D., Thompson, H. J., Pitkanen, A., Maxwell, W. L., Longhi, L., Laurer, H., Maegele, M., Neugebauer, E., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.030 · Cited by 339 · see citing works

Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?

David, Y., Cacheaux, L. P., Ivens, S., Lapilover, E., Heinemann, U., Kaufer, D., & Friedman, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2323-09.2009 · Cited by 337 · see citing works

The biphasic opening of the blood–brain barrier in the cortex and hippocampus after traumatic brain injury in rats

Başkaya, M. K., Muralikrishna Rao, A., Doğan, A., Donaldson, D., & Dempsey, R. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00239-5 · Cited by 332 · see citing works

IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-α, TGF-β1 and blood–brain barrier function

Csuka, E., Morganti-Kossmann, M. C., Lenzlinger, P. M., Joller, H., Trentz, O., & Kossmann, T. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00148-4 · Cited by 325 · see citing works

Hypoxia-Induced Hyperpermeability in Brain Microvessel Endothelial Cells Involves VEGF-Mediated Changes in the Expression of Zonula Occludens-1

Fischer, S., Wobben, M., Marti, H. H., Renz, D., & Schaper, W. K. A. (2002) · Microvascular Research · doi:10.1006/mvre.2001.2367 · Cited by 317 · see citing works

Pericyte Migration from the Vascular Wall in Response to Traumatic Brain Injury

Dore-Duffy, P., Owen, C., Balabanov, R., Murphy, S., Beaumont, T., & Rafols, J. A. (2000) · Microvascular Research · doi:10.1006/mvre.2000.2244 · Cited by 304 · see citing works

Blood‐spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing

Whetstone, W. D., Hsu, J. C., Eisenberg, M., Werb, Z., & Noble‐Haeusslein, L. J. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10759 · Cited by 288 · see citing works

Serum S-100β as a possible marker of blood–brain barrier disruption

Kapural, M., Križanac-Bengez, L., Barnett, G. H., Perl, J., Masaryk, T., Apollo, D., Rasmussen, P. A., Mayberg, M. R., & Janigro, D. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02586-6 · Cited by 285 · see citing works

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

Filosa, A., Paixão, S., Honsek, S. D., Carmona, M. A., Becker, L., Feddersen, B., Gaitanos, L., Rudhard, Y., Schoepfer, R., Klopstock, T., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2394 · Cited by 283 · see citing works

Increases in Bcl‐2 and cleavage of caspase‐1 and caspase‐3 in human brain after head injury

Clark, R. S. B., Kochanek, P. M., Chen, M., Watkins, S. C., Marion, D. W., Chen, J., Hamilton, R. L., Loeffert, J. E., & Graham, S. H. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.8.813 · Cited by 281 · see citing works

Enhancing Expression of Nrf2-Driven Genes Protects the Blood–Brain Barrier after Brain Injury

Zhao, J., Moore, A. N., Redell, J. B., & Dash, P. K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1683-07.2007 · Cited by 274 · see citing works

Blood–brain barrier breakdown-inducing astrocytic transformation: Novel targets for the prevention of epilepsy

Friedman, A., Kaufer, D., & Heinemann, U. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.03.005 · Cited by 270 · see citing works

Serum S100β

Kanner, A. A., Marchi, N., Fazio, V. J., et al. (2003) · Cancer · doi:10.1002/cncr.11409 · Cited by 269 · see citing works

Intracerebral Inflammation after Human Brain Contusion

Holmin, S., Söderlund, J., Biberfeld, P., & Mathiesen, T. I. (1998) · Neurosurgery · doi:10.1097/00006123-199802000-00047 · Cited by 268 · see citing works

New Roles for Interleukin-1 Beta in the Mechanisms of Epilepsy

Vezzani, A., & Baram, T. (2007) · Epilepsy Currents · doi:10.1111/j.1535-7511.2007.00165.x · Cited by 266 · see citing works

The blood–brain barrier is continuously open for several weeks following transient focal cerebral ischemia

Strbian, D., Durukan, A., Pitkonen, M., Marinković, I., Tatlısumak, E., Pedrono, E., Abo‐Ramadan, U., & Tatlisumak, T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.012 · Cited by 265 · see citing works

The risks of epilepsy after traumatic brain injury

Annegers, J. F., & Coan, S. P. (2000) · Seizure · doi:10.1053/seiz.2000.0458 · Cited by 256 · see citing works

Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation.

Li, Y., Chen, P., Haimovitz‐Friedman, A., Reilly, R. M., & Wong, C. S. (2003) · PubMed · Cited by 247 · see citing works

Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage

Cheng, T., Petraglia, A. L., Li, Z., Thiyagarajan, M., Zhong, Z., Wu, Z., Liu, D., Maggirwar, S. B., Deane, R., Fernández, J. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1498 · Cited by 247 · see citing works

Blood-brain barrier disruption in post-traumatic epilepsy

Tomkins‐Netzer, O., Shelef, I., Kaizerman, I., Eliushin, A., Afawi, Z., Misk, A. J., Gidon, M., Cohen, A., Zumsteg, D., & Friedman, A. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.126425 · Cited by 247 · see citing works

Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats

Carlos, T. M., Clark, R. S. B., Franicola-Higgins, D., Schiding, J. K., & Kochanek, P. M. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.61.3.279 · Cited by 242 · see citing works

Meta-Analysis of APOE 4 Allele and Outcome after Traumatic Brain Injury

Zhou, W., Xu, D., Peng, X., Zhang, Q., Jia, J., & Crutcher, K. A. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0489 · Cited by 241 · see citing works

Cerebral pressure autoregulation in traumatic brain injury

Rangel-Castilla, L., Gasco, J., Nauta, H. J. W., et al. (2008) · Neurosurgical FOCUS · doi:10.3171/foc.2008.25.10.e7 · Cited by 240 · see citing works

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

Keyser, J. D., Mostert, J. P., & Koch, M. W. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.08.044 · Cited by 235 · see citing works

Focal Cortical Dysfunction and Blood???Brain Barrier Disruption in Patients With Postconcussion Syndrome

Korn, A., Golan, H., Melamed, I., Pascual-Marqui, R. D., & Friedman, A. (2005) · Journal of Clinical Neurophysiology · doi:10.1097/01.wnp.0000150973.24324.a7 · Cited by 230 · see citing works

Intracerebral administration of interleukin-1β and induction of inflammation, apoptosis, and vasogenic edema

Holmin, S., & Mathiesen, T. I. (2000) · Journal of neurosurgery · doi:10.3171/jns.2000.92.1.0108 · Cited by 230 · see citing works

Increased caveolin-1 expression precedes decreased expression of occludin and claudin-5 during blood–brain barrier breakdown

Nag, S., Venugopalan, R., & Stewart, D. J. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0274-x · Cited by 227 · see citing works

Transcription Factor Nrf2 Protects the Brain From Damage Produced by Intracerebral Hemorrhage

Zhao, X., Sun, G., Zhang, J., Strong, R., Dash, P. K., Kan, Y. W., Grotta, J. C., & Aronowski, J. A. (2007) · Stroke · doi:10.1161/strokeaha.107.486506 · Cited by 227 · see citing works

Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury

Zhang, X., Chen, Y.-M., Jenkins, L., Kochanek, P., & Clark, R. (2004) · Critical Care · doi:10.1186/cc2950 · Cited by 223 · see citing works

Impaired K+Homeostasis and Altered Electrophysiological Properties of Post-Traumatic Hippocampal Glia

D’Ambrosio, R., Maris, D. O., Grady, M. S., Winn, H. R., & Janigro, D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08152.1999 · Cited by 221 · see citing works

Magnetic resonance imaging—monitored acute blood-brain barrier changes in experimental traumatic brain injury

Barzó, P., Marmarou, A., Fatouros, P. P., Corwin, F. D., & Dunbar, J. G. (1996) · Journal of neurosurgery · doi:10.3171/jns.1996.85.6.1113 · Cited by 203 · see citing works

Reversible Demyelination, Blood-Brain Barrier Breakdown, and Pronounced Neutrophil Recruitment Induced by Chronic IL-1 Expression in the Brain

Ferrari, C. C., Depino, A. M., Prada, F., Muraro, N. I., Campbell, S. J., Podhajcer, O. L., Perry, V. H., Anthony, D. C., & Pitossi, F. J. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63438-4 · Cited by 201 · see citing works

Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium

Harkness, K. A. (2000) · Brain · doi:10.1093/brain/123.4.698 · Cited by 195 · see citing works

Long-Term Cognitive Outcome in Moderate to Severe Traumatic Brain Injury: A Meta-Analysis Examining Timed and Untimed Tests at 1 and 4.5 or More Years After Injury

Ruttan, L., Martin, K., Liu, A. M. M., Colella, B., & Green, R. (2008) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.07.007 · Cited by 191 · see citing works

The Brain as a Target for Inflammatory Processes and Neuroprotective Strategies

Skaper, S. D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1403.002 · Cited by 191 · see citing works

Nitric Oxide in Traumatic Brain Injury

Cherian, L., Hlatky, R., & Robertson, C. S. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00053.x · Cited by 189 · see citing works

Inflammation in Human Brain Injury: Intracerebral Concentrations of IL-1 α , IL-1 β , and Their Endogenous Inhibitor IL-1ra

Hutchinson, P. J., O’Connell, M. T., Rothwell, N. J., Hopkins, S. J., Nortje, J., Carpenter, K. L. H., Timofeev, I. S., Al-Rawi, P. G., Menon, D. K., & Pickard, J. D. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0295 · Cited by 185 · see citing works

Blood–brain barrier disruption results in delayed functional and structural alterations in the rat neocortex

Tomkins‐Netzer, O., Friedman, O., Ivens, S., Reiffurth, C., Major, S., Dreier, J. P., Heinemann, U., & Friedman, A. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.006 · Cited by 175 · see citing works

Cerebral blood flow, arteriovenous oxygen difference, and outcome in head injured patients.

Robertson, C. S., Contant, C. F., Gokaslan, Z. L., Narayan, R. K., & Grossman, R. G. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.7.594 · Cited by 172 · see citing works

Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N‐Acetylcysteine

Chen, G., Shi, J., Hu, Z., & Hang, C. (2008) · Mediators of Inflammation · doi:10.1155/2008/716458 · Cited by 170 · see citing works

Traumatic Subarachnoid Hemorrhage: Demographic and Clinical Study of 750 Patients from the European Brain Injury Consortium Survey of Head Injuries

Servadei, F., Murray, G. D., Teasdale, G. M., Dearden, M., Iannotti, F., Lapierre, F., Maas, A. I. R., Karimi, A., Öhman, J. E., Persson, L., et al. (2002) · Neurosurgery · doi:10.1097/00006123-200202000-00006 · Cited by 165 · see citing works

Erythropoietin protects the in vitro blood–brain barrier against VEGF‐induced permeability

Martínez-Estrada, O. M., Rodríguez‐Millán, E., Vicente, E. G., Reina, M., Vilaró, S., & Fabre, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02987.x · Cited by 161 · see citing works

The European Brain Injury Consortium

Teasdale, G. M., Braakman, R., Cohadon, F., Dearden, M., Iannotti, F., Karimi, A., Lapierre, F., Maas, A. I. R., Murray, G. D., Öhman, J. E., et al. (1997) · Acta Neurochirurgica · doi:10.1007/bf01411397 · Cited by 160 · see citing works

Intrathecal Levels of Complement-Derived Soluble Membrane Attack Complex (sC5b-9) Correlate with Blood–Brain Barrier Dysfunction in Patients with Traumatic Brain Injury

Stahel, P. F., Morganti-Kossmann, M. C., Perez, D. R., Redaelli, C., Gloor, B., Trentz, O., & Kossmann, T. (2001) · Journal of Neurotrauma · doi:10.1089/089771501316919139 · Cited by 159 · see citing works

Hemodynamically significant cerebral vasospasm and outcome after head injury: a prospective study

Lee, J. H., Martin, N. A., Alsina, G., McArthur, D. L., Zaucha, K., Hovda, D. A., & Becker, D. P. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.87.2.0221 · Cited by 158 · see citing works

Blood-Brain Barrier Permeability, Cerebral Edema, and Neurologic Function After Closed Head Injury in Rats

Shapira, Y., Setton, D., Artru, A. A., & Shohami, E. (1993) · Anesthesia & Analgesia · doi:10.1213/00000539-199307000-00028 · Cited by 156 · see citing works

Role of Vascular Endothelial Growth Factor in Blood-Brain Barrier Breakdown and Angiogenesis in Brain Trauma

Nag, S., TAKAHASHI, J. L., & Kilty, D. W. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199708000-00009 · Cited by 152 · see citing works

Effects of Bradykinin on Permeability and Diameter of Pial Vessels In vivo

Unterberg, A. W., Wahl, M., & Baethmann, A. J. (1984) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1984.82 · Cited by 150 · see citing works

Inhibition of Hypoxia-Induced Increase of Blood-Brain Barrier Permeability by YC-1 through the Antagonism of HIF-1α Accumulation and VEGF Expression

Yeh, W., Lu, D., Lin, C., Liou, H., & Fu, W. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.036418 · Cited by 150 · see citing works

Isoform‐Specific Effects of Apolipoproteins E2, E3, and E4 on Cerebral Capillary Sequestration and Blood‐Brain Barrier Transport of Circulating Alzheimer's Amyloid β

Martel, C. L., Mackic, J. B., Matsubara, E., Governale, S., Miguel, C., Miao, W., McComb, J. G., Frangione, B., Ghiso, J., & Zlokovic, B. V. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69051995.x · Cited by 149 · see citing works

Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

Chen, X., Gawryluk, J. W., Wagener, J. F., Ghribi, O., & Geiger, J. D. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-12 · Cited by 147 · see citing works

TGF-β Is Elevated in the CSF of Patients with Severe Traumatic Brain Injuries and Parallels Blood-Brain Barrier Function

Morganti-Kossmann, M. C., Hans, V., Lenzlinger, P. M., Dubs, R. W., LUDWIG, E., Trentz, O., & Kossmann, T. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.617 · Cited by 147 · see citing works

Homeostasis of glutamate in brain fluids: An accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies

Teichberg, V. I., Malina, K. C.-K., Cooper, I., & Zlotnik, A. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.075 · Cited by 135 · see citing works

Theoretical Basis of Hemodynamic MR Imaging Techniques to Measure Cerebral Blood Volume, Cerebral Blood Flow, and Permeability

Zaharchuk, G. (2007) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0831 · Cited by 134 · see citing works

Dexamethasone coordinately regulates angiopoietin-1 and VEGF: A mechanism of glucocorticoid-induced stabilization of blood–brain barrier

Kim, S., Lee, J. M., Park, J. S., Jo, S. A., Kim, Y., Kim, C., & Jo, I. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.025 · Cited by 133 · see citing works

Increased Matrix Metalloproteinase-9 in Blood in Association with Activation of Interleukin-6 after Traumatic Brain Injury: Influence of Hypothermic Therapy

Suehiro, E., Fujisawa, H., Akimura, T., Ishihara, H., Kajiwara, K., Kato, S., Fujii, M., Yamashita, S., Maekawa, T., & Suzuki, M. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1706 · Cited by 132 · see citing works

Morphological features in human cortical brain microvessels after head injury: A three‐dimensional and immunocytochemical study

Rodríguez‐Baeza, A., Reina, F., Poca, M. A., Martí, M., & Garnacho, A. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10069 · Cited by 131 · see citing works

Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus

Nicoletti, J. N., Shah, S. K., McCloskey, D. P., Goodman, J. H., Elkady, A., Atassi, H., Hylton, D., Rudge, J. S., Scharfman, H. E., & Croll, S. D. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.083 · Cited by 131 · see citing works

Inflammation and brain edema: new insights into the role of chemokines and their receptors

Stamatovic, S. M., Dimitrijevic, O. B., Keep, R. F., & Andjelkovic, A. V. (2006) · Springer eBooks · doi:10.1007/3-211-30714-1_91 · Cited by 125 · see citing works

Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: A potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO)

Chen, G., Shi, J. X., Hang, C. H., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.08.022 · Cited by 119 · see citing works

The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid β Peptides in an in Vitro Model of the Blood-Brain Barrier Cells

Yamada, K., Hashimoto, T., Yabuki, C., Nagae, Y., Tachikawa, M., Strickland, D. K., Liu, Q., Bu, G., Basak, J. M., Holtzman, D. M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801487200 · Cited by 119 · see citing works

Astrocytic function and its alteration in the epileptic brain

Jabs, R., Seifert, G., & Steinhäuser, C. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01488.x · Cited by 116 · see citing works

Neuroprotection by erythropoietin administration after experimental traumatic brain injury

Grasso, G., Sfacteria, A., Meli, F., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.078 · Cited by 116 · see citing works

Influence of Therapeutic Hypothermia on Matrix Metalloproteinase Activity after Traumatic Brain Injury in Rats

Truettner, J. S., Alonso, O. F., & Dietrich, W. D. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600150 · Cited by 114 · see citing works

Role of the Cell Cycle in the Pathobiology of Central Nervous System Trauma

Černak, I., Stoica, B. A., Byrnes, K. R., Giovanni, S. D., & Faden, A. I. (2005) · Cell Cycle · doi:10.4161/cc.4.9.1996 · Cited by 112 · see citing works

Decreased junctional adhesion molecule-A expression during blood–brain barrier breakdown

Yeung, D., Manias, J. L., Stewart, D. J., & Nag, S. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0364-4 · Cited by 111 · see citing works

Alterations of Glial Cell Function in Temporal Lobe Epilepsy

Heinemann, U., Gabriel, S., Jauch, R., Schulze, K., Kivi, A., Eilers, A., Kovacs, R., & Lehmann, T. N. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb01579.x · Cited by 105 · see citing works

Traumatic Brain Injury Elevates the Alzheimer's Amyloid Peptide Aβ42 in Human CSF: A Possible Role for Nerve Cell Injury

Emmerling, M., Morganti-Kossmann, M., Kossmann, T., Stahel, P. F., Watson, M. D., Evans, L., Mehta, P., Spiegel, K., Kuo, Y.-M., Roher, A., et al. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06357.x · Cited by 104 · see citing works

Imaging Inflammation in Acute Brain Ischemia

Jander, S., Schroeter, M., & Saleh, A. (2007) · Stroke · doi:10.1161/01.str.0000250048.42916.ad · Cited by 101 · see citing works

Blood Brain Barrier Permeability and Acute Inflammation in Two Models of Traumatic Brain Injury in the Immature Rat: A Preliminary Report

Adelson, P. D., Whalen, M. J., Kochanek, P. M., Robichaud, P., & Carlos, T. M. (1998) · Springer eBooks · doi:10.1007/978-3-7091-6475-4_31 · Cited by 100 · see citing works

Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis.

Jeynes, B., & Provias, J. (2008) · Current Alzheimer Research · doi:10.2174/156720508785908937 · Cited by 99 · see citing works

Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice

Xiong, Y., Lu, D., Qu, C., Goussev, A. V., Schallert, T. J., Mahmood, A., & Chopp, M. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/109/9/0510 · Cited by 98 · see citing works

Altered Immunoexpression of Microglia and Macrophages after Mild Head Injury

Aihara, N., Hall, J. J., Pitts, L. H., et al. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.53 · Cited by 97 · see citing works

T Lymphocyte Trafficking: A Novel Target for Neuroprotection in Traumatic Brain Injury

Clausen, F., Lorant, T., Lewén, A., & Hillered, L. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0258 · Cited by 95 · see citing works

High level of extracellular potassium and its correlates after severe human head injury: relationship to high intracranial pressure

Reinert, M., Khaldi, A., Zauner, A., DOPPENBERG, E. M. R., Choi, S. C., & Bullock, R. M. (2000) · Journal of neurosurgery · doi:10.3171/jns.2000.93.5.0800 · Cited by 94 · see citing works

Frequent Blood–Brain Barrier Disruption in the Human Cerebral Cortex

Tomkins‐Netzer, O., Kaufer, D., Korn, A., Shelef, I., Golan, H., Reichenthal, E., Soreq, H., & Friedman, A. (2001) · Cellular and Molecular Neurobiology · doi:10.1023/a:1015147920283 · Cited by 92 · see citing works

Moderate and severe traumatic brain injury induce early overexpression of systemic and brain gelatinases

Vilalta, A., Sahuquillo, J., Rosell, A., Poca, M. A., Riveiro, M., & Montaner, J. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1056-1 · Cited by 91 · see citing works

Soluble ICAM-1 in CSF Coincides with the Extent of Cerebral Damage in Patients with Severe Traumatic Brain Injury

Pleines, U. E., Stover, J., Kossmann, T., Trentz, O., & Morganti-Kossmann, M. C. (1998) · Journal of Neurotrauma · doi:10.1089/neu.1998.15.399 · Cited by 91 · see citing works

Expression of endothelial phosphorylated caveolin‐1 is increased in brain injury

Nag, S., Manias, J. L., & Stewart, D. J. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01009.x · Cited by 90 · see citing works

Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype

Jellinger, K. A., Paulus, W., Wrocklage, C., & Litvan, I. (2001) · BMC Neurology · doi:10.1186/1471-2377-1-3 · Cited by 86 · see citing works

The effects of nicotinamide on apoptosis and blood-brain barrier breakdown following traumatic brain injury.

Hoane, M., Kaplan, S., & Ellis, A. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.10.019 · Cited by 85 · see citing works

The blood–brain barrier and cerebral angiogenesis: lessons from the cold-injury model

Nag, S. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02221-3 · Cited by 84 · see citing works

Apolipoprotein E4 as a Predictor of Outcomes in Pediatric Mild Traumatic Brain Injury

Moran, L. M., Taylor, H. G., Ganesalingam, K., Gastier, J. M., Frick, J., Bangert, B. A., Dietrich, A. M., Nuss, K. E., Rusin, J. A., Wright, M., et al. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0767 · Cited by 82 · see citing works

Increased angiopoietin2 expression is associated with endothelial apoptosis and blood–brain barrier breakdown

Nag, S., Papneja, T., Venugopalan, R., et al. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700325 · Cited by 81 · see citing works

Astroglia: Important mediators of traumatic brain injury

Floyd, C. L., & Lyeth, B. G. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)61005-4 · Cited by 80 · see citing works

Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans

Lenzlinger, P. M., Marx, A., Trentz, O., Kossmann, T., & Morganti-Kossmann, M. C. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00466-0 · Cited by 74 · see citing works

Coagulation Abnormalities Associated with Severe Isolated Traumatic Brain Injury: Cerebral Arterio-Venous Differences in Coagulation and Inflammatory Markers

Nekludov, M., Antović, J. P., Bredbacka, S., et al. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0173 · Cited by 73 · see citing works

Endothelial cell activation following moderate traumatic brain injury

Balabanov, R. D., Goldman, H., Murphy, S., Pellizzon, G. G., Owen, C. R., Rafols, J. A., & Dore‐Duffy, P. (2001) · Neurological Research · doi:10.1179/016164101101198514 · Cited by 70 · see citing works

Intrathecal and Systemic Concentration of NT-proBNP in Patients with Severe Traumatic Brain Injury

Kirchhoff, C., Stegmaier, J., Bogner, V., et al. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.943 · Cited by 65 · see citing works

Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia

Yan, F., Zheng, Y., & Zhao, F. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0435-6 · Cited by 62 · see citing works

Activated Protein C is Neuroprotective and Mediates New Blood Vessel Formation and Neurogenesis After Controlled Cortical Impact

Petraglia, A. L., Marky, A. H., Walker, C. T., Thiyagarajan, M., & Zloković, B. V. (2009) · Neurosurgery · doi:10.1227/01.neu.0000363148.49779.68 · Cited by 62 · see citing works

Recombinant human erythropoietin administration protects cortical neurons from traumatic brain injury in rats

Liao, Z., Zhi, X. G., Shi, Q., et al. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.02013.x · Cited by 61 · see citing works

Evaluation of apoptosis in cerebrospinal fluid of patients with severe head injury

Uzan, M., Erman, H., Tanriverdi, T., Sanus, G. Z., Kafadar, A., & Uzun, H. (2006) · Acta Neurochirurgica · doi:10.1007/s00701-006-0887-1 · Cited by 61 · see citing works

Role of Bradykinin B 2 Receptors in the Formation of Vasogenic Brain Edema in Rats

Plesnila, N., Schulz, J., Stoffel, M. H., et al. (2001) · Journal of Neurotrauma · doi:10.1089/08977150152693746 · Cited by 60 · see citing works

Blood-Brain Barrier Damage Induces Release of α2-Macroglobulin

Cucullo, L., Marchi, N., Marroni, M., Fazio, V. J., Namura, S., & Janigro, D. (2003) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200077-mcp200 · Cited by 60 · see citing works

Blood–brain barrier breakdown as a novel mechanism underlying cerebral hyperperfusion syndrome

Ivens, S., Szendro, G., Greenberg, G., et al. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5384-z · Cited by 58 · see citing works

Head injuries and cognitive decline among older adults

Luukinen, H., Viramo, P., Koski, K., Laippala, P. J., & Kivelä, S. (1999) · Neurology · doi:10.1212/wnl.52.3.557 · Cited by 54 · see citing works

Effects of anti-VEGF antibody on blood–brain barrier disruption in focal cerebral ischemia

CHI, O. Z., Hunter, C., Liu, X., & Weiss, H. R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.11.001 · Cited by 54 · see citing works

Factors Predictive of Outcome in Posttraumatic Seizures

Wang, H., Chang, W., Chang, H., Ho, J.-T., Yang, T.-M., Lin, W.-C., Chuang, Y., & Lu, C. (2008) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e31804a7fa4 · Cited by 54 · see citing works

Differential Neuroprotection and Risk for Bleeding From Activated Protein C With Varying Degrees of Anticoagulant Activity

Wang, Y., Thiyagarajan, M., Chow, N., Singh, I., Guo, H., Davis, T. P., & Zloković, B. V. (2008) · Stroke · doi:10.1161/strokeaha.108.536680 · Cited by 52 · see citing works

Persistent BBB disruption may underlie alpha interferon-induced seizures

Pavlovsky, L., Seiffert, E., Heinemann, U., Korn, A., Golan, H., & Friedman, A. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0596-3 · Cited by 47 · see citing works

Blood-Brain Barrier Genomics

Pardridge, W. M. (2007) · Stroke · doi:10.1161/01.str.0000247887.61831.74 · Cited by 45 · see citing works

Antibodies to Serotonin Attenuate Closed Head Injury Induced Blood–Brain Barrier Disruption and Brain Pathology

Sharma, H. S., PATNAIK, R., PATNAIK, S., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1403.022 · Cited by 45 · see citing works

New developments in understanding and treating neuroinflammation

Infante-Duarte, C., Waiczies, S., Wuerfel, J., & Zipp, F. (2008) · Journal of molecular medicine · doi:10.1007/s00109-007-0292-0 · Cited by 45 · see citing works

Acute Effects of Calvarial Damage on Dural Mast Cells, Pial Vascular Permeability, and Cerebral Cortical Histamine Levels in Rats and Mice

Stokely, M. E., & Orr, E. L. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0397 · Cited by 42 · see citing works

Traumatic Brain Contusions: A Clinical Role for the Kinin Antagonist CP-0127

Narotam, P. K., Rodell, T. C., Nadvi, S. S., Bhoola, K. D., Troha, J. M., Parbhoosingh, R., & van Dellen, J. R. (1998) · Acta Neurochirurgica · doi:10.1007/s007010050181 · Cited by 41 · see citing works

Treatment with ranitidine of ischemic brain edema

Tósaki, Á., Szerdahelyi, P., & Joó, F. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00546-x · Cited by 41 · see citing works

Post-Traumatic Hyperexcitability Is Not Caused by Impaired Buffering of Extracellular Potassium

Santhakumar, V., Voipio, J., Kaila, K., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05865.2003 · Cited by 38 · see citing works

Acutely increased cyclophilin a expression after brain injury: A role in blood‐brain barrier function and tissue preservation

Redell, J. B., Zhao, J., & Dash, P. K. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21324 · Cited by 36 · see citing works

In situ DNA fragmentation occurs in white matter up to 12 months after head injury in man

Williams, S. E., Raghupathi, R., MacKinnon, M., Mcintosh, T. K., Saatman, K., & Graham, D. I. (2001) · Acta Neuropathologica · doi:10.1007/s004010100410 · Cited by 33 · see citing works

Microvascular Basal Lamina Antigen Loss after Traumatic Brain Injury in the Rat

Müllner, A., Benz, M., Kloss, C. U. A., Mautes, A. E. M., Burggraf, D., & Hamann, G. F. (2003) · Journal of Neurotrauma · doi:10.1089/089771503767869971 · Cited by 25 · see citing works

Centers for Disease Control and Prevention

Crews, J. E. (2005) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/01.phm.0000189841.18419.16 · Cited by 25 · see citing works

Bradykinin B2 Receptor Antagonism With LF 18-1505T Reduces Brain Edema and Improves Neurological Outcome After Closed Head Trauma in Rats

Ivashkova, Y., Svetnitsky, A., Mayzler, O., et al. (2006) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000234722.98537.01 · Cited by 24 · see citing works

Bradykinin beta-2 receptor antagonists for acute traumatic brain injury

Ker, K., & Blackhall, K. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006686.pub2 · Cited by 21 · see citing works

Bradykinin 2 Receptor Antagonist LF 16-0687Ms Reduces Posttraumatic Brain Edema

Stover, J., Dohse, N.-K., & Unterberg, A. W. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6346-7_34 · Cited by 12 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

The role of inflammation in epilepsy

Vezzani, A., French, J., Bartfai, T., & Baram, T. Z. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.178 · Cited by 1,876 · see citing works

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799 · see citing works

The blood-brain barrier: an engineering perspective

Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662 · see citing works

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

Petersen, M. A., Ryu, J. K., & Akassoglou, K. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.13 · Cited by 527 · see citing works

Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore

Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., et al. (2016) · Advanced Materials · doi:10.1002/adma.201600706 · Cited by 386 · see citing works

The anatomy and immunology of vasculature in the central nervous system

Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333 · see citing works

Blood−brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

Prakash, R., & Carmichael, S. T. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000248 · Cited by 296 · see citing works

Blood-brain barrier permeability and physical exercise

Małkiewicz, M. A., Szarmach, A., Sabisz, A., Cubała, W. J., Szurowska, E., & Winklewski, P. J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1403-x · Cited by 276 · see citing works

Losartan prevents acquired epilepsy via TGF‐β signaling suppression

Bar‐Klein, G., Cacheaux, L. P., Kamintsky, L., Prager, O., Weissberg, I., Schoknecht, K., Cheng, P., Kim, S. Y., Wood, L., Heinemann, U., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24147 · Cited by 270 · see citing works

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells

Qian, T., Maguire, S. E., Canfield, S. G., Bao, X., Olson, W. R., Shusta, E. V., & Palecek, S. P. (2017) · Science Advances · doi:10.1126/sciadv.1701679 · Cited by 254 · see citing works

Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

Najjar, S., Pearlman, D. M., Devinsky, O., Najjar, A., & Zagzag, D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-142 · Cited by 248 · see citing works

Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells

Stebbins, M. J., Wilson, H. K., Canfield, S. G., Qian, T., Palecek, S. P., & Shusta, E. V. (2016) · Methods · doi:10.1016/j.ymeth.2015.10.016 · Cited by 179 · see citing works

Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products

Zhang, Z., Zoltewicz, J. S., Mondello, S., Newsom, K. J., Yang, Z., Yang, B., Kobeissy, F., Guingab, J., Glushakova, O., Robicsek, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092698 · Cited by 200 · see citing works

Single cell molecular alterations reveal target cells and pathways of concussive brain injury

Arneson, D., Zhang, G., Ying, Z., Zhuang, Y., Byun, H. R., Ahn, I. S., Gomez-Pinilla, F., & Yang, X. (2018) · Nature Communications · doi:10.1038/s41467-018-06222-0 · Cited by 193 · see citing works

Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury mice

Li, H., Sun, J., Wang, F., Ding, G., Chen, W., Fang, R., Yao, Y., Pang, M., Lu, Z.-Q., & Liu, J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.031 · Cited by 152 · see citing works

Cytoprotective protein C pathways and implications for stroke and neurological disorders

Zlokovic, B. V., & Griffin, J. H. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.01.005 · Cited by 128 · see citing works

Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges

Zipfel, P., Rochais, C., Baranger, K., Rivera, S., & Dallemagne, P. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00352 · Cited by 94 · see citing works

Ensemble of expert deep neural networks for spatio-temporal denoising of contrast-enhanced MRI sequences

Benou, A., Veksler, R., Friedman, A., & Riklin Raviv, T. (2017) · Medical Image Analysis · doi:10.1016/j.media.2017.07.006 · Cited by 91 · see citing works

Extracellular Vesicle Proteins and MicroRNAs as Biomarkers for Traumatic Brain Injury

Guedes, V. A., Devoto, C., Leete, J., Sass, D., Acott, J. D., Mithani, S., & Gill, J. M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00663 · Cited by 85 · see citing works

Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood–Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B

Ge, X., Li, W., Huang, S., Yin, Z., Yang, M., Han, Z., Han, Z., Chen, F., Wang, H., Lei, P., et al. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.5728 · Cited by 77 · see citing works

Role of P2X7 Receptors in Immune Responses During Neurodegeneration

Oliveira-Giacomelli, Á., Petiz, L. L., Andrejew, R., Turrini, N., Silva, J. B., Sack, U., & Ulrich, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.662935 · Cited by 68 · see citing works

Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, “M-type”) K ⁺ currents in neurons

Vigil, F. A., Bozdemir, E., Bugay, V., Chun, S. H., Hobbs, M., Sanchez, I., Hastings, S. D., Veraza, R. J., Holstein, D. M., Sprague, S. M., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19857818 · Cited by 51 · see citing works

Extracellular vesicles: pathogenetic, diagnostic and therapeutic value in traumatic brain injury

Mondello, S., Thelin, E. P., Shaw, G., Salzet, M., Visalli, C., Cizkova, D., Kobeissy, F., & Buki, A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1464914 · Cited by 53 · see citing works

Head Injury and Amyotrophic Lateral Sclerosis: A Meta-Analysis

Liu, G., Ou, S., Cui, H., Li, X., Yin, Z., Gu, D., & Wang, Z. (2021) · Neuroepidemiology · doi:10.1159/000510987 · Cited by 41 · see citing works

Cryopreservation of Brain Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Is Enhanced by Rho-Associated Coiled Coil-Containing Kinase Inhibition

Wilson, H. K., Faubion, M. G., Hjortness, M. K., Palecek, S. P., & Shusta, E. V. (2016) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2016.0345 · Cited by 29 · see citing works

NEUROVASCULAR PEDICLE TRANSFERS IN THE HAND*

OʼBrien, B. M. (1965) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1965.tb06217.x · Cited by 21 · see citing works

Neurovascular pedicle transfers in the hand.

OʼBrien, B. M. (1965) · PubMed · Cited by 19 · see citing works

A further use for the neurovascular island flap principle in hand surgery: The piggy-back flap

Snell, J. A. (1969) · British Journal of Plastic Surgery · doi:10.1016/s0007-1226(69)80056-1 · Cited by 3 · see citing works

Evaluation of Radical Prostatectomy Capsular Margins of Resection

Epstein, J. I. (1990) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199007000-00003 · Cited by 133 · see citing works

Influence of Wide Excision of the Neurovascular Bundle(s) on Prognosis in Men with Clinically Localized Prostate Cancer with Established Capsular Penetration

Partin, A. W., Borland, R. N., Epstein, J. I., et al. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)35416-2 · Cited by 113 · see citing works