The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Risks and benefits of human germline genome editing: An ethical analysis
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“One aspect of i-HGE that makes informed consent difficult is the possibility of adverse effects occurring either later in the life of first-generation gene-edited persons or only in subsequent generations (Rubeis and Steger 2018).”
From Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic (2023) · cites this paper as Rubeis and Steger 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Correction of a pathogenic gene mutation in human embryos
Ma, H., Marti-Gutierrez, N., Park, S.-W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., et al. (2017) · Nature · doi:10.1038/nature23305 · Cited by 992
A prudent path forward for genomic engineering and germline gene modification
Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R. A., Church, G., Corn, J. E., Daley, G. Q., Doudna, J. A., Fenner, M., et al. (2015) · Science · doi:10.1126/science.aab1028 · Cited by 733
Don’t edit the human germ line
Lanphier, E., Urnov, F., Haecker, S. E., Werner, M., & Smolenski, J. (2015) · Nature · doi:10.1038/519410a · Cited by 530
The Ethics of Germline Gene Editing
Gyngell, C., Douglas, T., & Savulescu, J. (2017) · Journal of Applied Philosophy · doi:10.1111/japp.12249 · Cited by 174 · cited 5×
“As Gyngell et al. (2017) claim, for some reproduction partners GGE would be the only option to create offspring that is genetically related to both.”
BackgroundMethodInfluentialHuman Genome Editing: Science, Ethics, and Governance
Committee on Human Gene Editing: Scientific, M., National Academy of Sciences, National Academy of Medicine, & National Academies of Sciences, E. (2017) · doi:10.17226/24623 · Cited by 144
Flagged first, then by citations
Research works printed but not linked: 14
- Baylis, F. 2013. The ethics of creating children with three genetic parents. Reproductive Biomedicine Online 26: 531–534. https://doi.org/10.1016/j.rbmo.2013.03.006 . · DOI
- Callaway, E. 2016. UK scientists gain licence to edit genes in human embryos. Nature 530. https://doi.org/10.1038/nature.2016.19270 . · DOI
- Hildt, E. 2016. Human germline interventions–think first. Frontiers in Genetics 7. https://doi.org/10.3389/fgene.2016.00081 . · DOI
- Ishii, T. 2017a. Germ line genome editing in clinics: the approaches, objectives and global society. Briefings in Functional Genomics 16: 46–56. https://doi.org/10.1093/bfgp/elv053 . · DOI
- Ishii, T. 2017b. Reproductive medicine involving genome editing: clinical uncertainties and embryological needs. Reproductive Biomedicine Online 34: 27–31. https://doi.org/10.1016/j.rbmo.2016.09.009 . · DOI
- Kang, X., W. He, Y. Huang, Q. Yu, Y. Chen, X. Gao, X. Sun, and Y. Fan. 2016. Introducing precise genetic modifications into human 3PN-embryos by CRISPR/Cas-mediated genome editing. Journal of Assisted Reproduction and Genetics 33: 581–588. https://doi.org/10.1007/s10815-016-0710-8 . · DOI
- Liang, P., Y. Xu, X. Zhang, C. Ding, R. Huang, Z. Zhang, J. Lu, X. Xie, Y. Chen, Y. Li, Y. Sun, Y. Bai, S. Zhou, W. Ma, C. Zhou, and J. Huang. 2015. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & Cell 6: 363–372. https://doi.org/10.1007/s13238-015-0153-5 . · DOI · Paper page
- Long, C., J.R. McAnally, J.M. Shelton, A.A. Mireault, R. Bassel-Duby, and E.N. Olson. 2014. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science 345: 1184–1188. https://doi.org/10.1126/science.1254445 . · DOI · Paper page
- Ormond, K.E., D.P. Mortlock, D.T. Scholes, Y. Bombard, L.C. Brody, W.A. Faucett, N.A. Garrison, L. Hercher, R. Isassi, A. Middleton, K. Musunuru, D. Shriner, A. Virani, and C.E. Young. 2017. Human Germline Genome Editing. American Journal of Human Genetics 101: 167–176. https://doi.org/10.1016/j.ajhg.2017.06.012. · DOI · Paper page
- Powell, R. 2015. In genes we trust: Germline engineering, eugenics, and the future of the human genome. Journal of Medicine and Philosophy 40:669–695. https://doi.org/10.1093/jmp/jhv025 . · DOI
- Rubeis, G., and F. Steger. 2016. Genome Editing in der Pränatalmedizin. Eine medizinethische Analyse. In Jahrbuch für Recht und Ethik - Annual Review of Law and Ethics, ed. Sharon B. Byrd, Joachim Hruschka, and Jan C. Joerden, vol. 24, 143–159. Berlin: Duncker & Humblot.
- Savulescu, J., and C. Gyngell. 2015. The medical case for gene editing. Ethics in Biology, Engineering and Medicine 6: 57–66. · DOI
- Savulescu, J., J. Pugh, T. Douglas, and C. Gyngell. 2015. The moral imperative to continue gene editing research on human embryos. Protein & Cell 6: 476–479. https://doi.org/10.1007/s13238-015-0184-y . · DOI
- Vij, S.C., E. Sabanegh Jr., and A. Ashok. 2018. Biological therapy for non-obstructive azoospermia. Expert Opinion on Biological Therapy 18: 19–23. https://doi.org/10.1080/14712598.2018.1380622 . · DOI
Cited by
Sorted by citations
Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic
Ranisch, R., Trettenbach, K., & Arnason, G. (2023) · Medicine, Health Care and Philosophy · doi:10.1007/s11019-022-10115-x · Cited by 19
Metadata
- Authors
- Rubeis, G., & Steger, F.
- Venue
- Asian Bioethics Review
- Published
- 2018-07
- Volume
- 10
- Issue
- 2
- Pages
- 133-141
- ISSN
- 1793-8759
- 1793-9453
- Cited by
- 49
- References
- 5
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review