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Risks and benefits of human germline genome editing: An ethical analysis

Rubeis, Giovanni, Steger, Florian·2018·Asian Bioethics Review

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  1. Baylis, F. 2013. The ethics of creating children with three genetic parents. Reproductive Biomedicine Online 26: 531–534. https://doi.org/10.1016/j.rbmo.2013.03.006 . · DOI
  2. Callaway, E. 2016. UK scientists gain licence to edit genes in human embryos. Nature 530. https://doi.org/10.1038/nature.2016.19270 . · DOI
  3. Hildt, E. 2016. Human germline interventions–think first. Frontiers in Genetics 7. https://doi.org/10.3389/fgene.2016.00081 . · DOI
  4. Ishii, T. 2017a. Germ line genome editing in clinics: the approaches, objectives and global society. Briefings in Functional Genomics 16: 46–56. https://doi.org/10.1093/bfgp/elv053 . · DOI
  5. Ishii, T. 2017b. Reproductive medicine involving genome editing: clinical uncertainties and embryological needs. Reproductive Biomedicine Online 34: 27–31. https://doi.org/10.1016/j.rbmo.2016.09.009 . · DOI
  6. Kang, X., W. He, Y. Huang, Q. Yu, Y. Chen, X. Gao, X. Sun, and Y. Fan. 2016. Introducing precise genetic modifications into human 3PN-embryos by CRISPR/Cas-mediated genome editing. Journal of Assisted Reproduction and Genetics 33: 581–588. https://doi.org/10.1007/s10815-016-0710-8 . · DOI
  7. Liang, P., Y. Xu, X. Zhang, C. Ding, R. Huang, Z. Zhang, J. Lu, X. Xie, Y. Chen, Y. Li, Y. Sun, Y. Bai, S. Zhou, W. Ma, C. Zhou, and J. Huang. 2015. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & Cell 6: 363–372. https://doi.org/10.1007/s13238-015-0153-5 . · DOI · Paper page
  8. Long, C., J.R. McAnally, J.M. Shelton, A.A. Mireault, R. Bassel-Duby, and E.N. Olson. 2014. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science 345: 1184–1188. https://doi.org/10.1126/science.1254445 . · DOI · Paper page
  9. Ormond, K.E., D.P. Mortlock, D.T. Scholes, Y. Bombard, L.C. Brody, W.A. Faucett, N.A. Garrison, L. Hercher, R. Isassi, A. Middleton, K. Musunuru, D. Shriner, A. Virani, and C.E. Young. 2017. Human Germline Genome Editing. American Journal of Human Genetics 101: 167–176. https://doi.org/10.1016/j.ajhg.2017.06.012. · DOI · Paper page
  10. Powell, R. 2015. In genes we trust: Germline engineering, eugenics, and the future of the human genome. Journal of Medicine and Philosophy 40:669–695. https://doi.org/10.1093/jmp/jhv025 . · DOI
  11. Rubeis, G., and F. Steger. 2016. Genome Editing in der Pränatalmedizin. Eine medizinethische Analyse. In Jahrbuch für Recht und Ethik - Annual Review of Law and Ethics, ed. Sharon B. Byrd, Joachim Hruschka, and Jan C. Joerden, vol. 24, 143–159. Berlin: Duncker & Humblot.
  12. Savulescu, J., and C. Gyngell. 2015. The medical case for gene editing. Ethics in Biology, Engineering and Medicine 6: 57–66. · DOI
  13. Savulescu, J., J. Pugh, T. Douglas, and C. Gyngell. 2015. The moral imperative to continue gene editing research on human embryos. Protein & Cell 6: 476–479. https://doi.org/10.1007/s13238-015-0184-y . · DOI
  14. Vij, S.C., E. Sabanegh Jr., and A. Ashok. 2018. Biological therapy for non-obstructive azoospermia. Expert Opinion on Biological Therapy 18: 19–23. https://doi.org/10.1080/14712598.2018.1380622 . · DOI

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Metadata

Authors
Rubeis, G., & Steger, F.
Venue
Asian Bioethics Review
Published
2018-07
Volume
10
Issue
2
Pages
133-141
ISSN
  • 1793-8759
  • 1793-9453
Cited by
49
References
5
Language
en

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