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Cited by 2Nutrition and Health in AgingMuscle Physiology and DisordersFrailty in Older Adults

Muscle-specific strength and its functional correlates in patients with osteosarcopenia

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Şengül Ayçiçek, G., Caran Karabacak, E., Gökçe, B., Oktay Oğuz, E., Koca, M., Ünsal, P.·2025·European Geriatric Medicine
DOI 10.1007/s41999-025-01256-2PMC PMC12528226
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Abstract

Methods: One hundred seventy patients were enrolled in this study and 141 patients were analyzed. Hand grip strength (HGS) was measured with Jamar dynamometer, muscle mass was measured with ultrasound, and sarcopenia diagnosis based on low muscle strength and low muscle mass. Muscle specific strength is calculated as HGS to muscle thickness (kg/cm) and cross-sectional area (kg/cm 2). Osteoporosis is diagnosed if the T score was below − 2.5 or fragility fracture is present. The patients with both osteoporosis and sarcopenia were accepted as osteosarcopenia. Results: Mean age of the patients was 76.86 ± 6.74 and 121 (71.2%) were female. Ten percent of the patients was osteoporotic, 25.9% was sarcopenic and 27.1% was osteosarcopenic. In patients with osteosarcopenia, HGS/ Rectus femoris thickness (kg/cm) was 11.35 (2.47–37.5); HGS / Rectus femoris cross sectional area (kg/cm2) was 5.16 (0.82–27.3) and HGS/ Quadriceps femoris thickness (kg/cm) was 5.4 (1.43–13.04). When compared to control, osteoporosis and sarcopenia groups, muscle specific strength was lower in the osteosarcopenia group (p < 0.001, p = 0.009, p < 0.001, respectively). Linear regression analyses revealed that muscle specific strength was significantly associated with timed up and go (TUG) (β = − 0.236, p = 0.030) and L1-L4 T score (β = − 0.233, p = 0.032). Conclusion: Muscle specific strength- especially rectus femoris and quadriceps femoris thickness—is associated with TUG and L1-L4 scores in osteosarcopenia patients.

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  • Şengül Ayçiçek et al. (2025) demonstrated strong correlations between rectus femoris thickness and functional parameters such as handgrip strength and gait velocity.

    “Şengül Ayçiçek et al. (2025) have demonstrated strong correlations between rectus femoris thickness and functional parameters such as HGS and gait velocity [151].”

    From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [151]

    The Methods report measuring rectus femoris thickness and handgrip strength, and the Results report an association between Timed Up and Go performance and muscle-specific strength calculated as handgrip strength divided by rectus femoris thickness (β = −0.236, p = 0.030). They do not demonstrate strong direct correlations between rectus femoris thickness and either handgrip strength or gait velocity; gait velocity was not reported as a separate outcome. (LLM, conf=0.86)

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Authors
Şengül Ayçiçek, G., Caran Karabacak, E., Gökçe, B., Oktay Oğuz, E., Koca, M., & Ünsal, P.
Affiliations
  • Ankara Etlik City Hospital (TR)
  • Ankara Yıldırım Beyazıt University (TR)
ORCID
Venue
European Geriatric Medicine
Publisher
Springer Science and Business Media LLC
Published
2025-06-11
Volume
16
Issue
5
Pages
1753-1758
ISSN
  • 1878-7649 (ISSN-L)
  • 1878-7657
DOI
10.1007/s41999-025-01256-2
PMC
PMC12528226
OpenAlex
W4411207532
Cited by
2
References
3
Citations by year
2026: 2
FWCI
1.29
Type
journal article
Language
en
Open access
Licence
Locations
  • European Geriatric Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • AYBU AVESIS (submittedVersion)
Funders
University of Health Sciences
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords
osteosarcopenia, grip strength, sarcopenia, osteoporosis, Timed Up and Go test, T-score, older adults, functional performance
MeSH terms
Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Osteoporosis, Ultrasonography, Muscle, Skeletal, Hand Strength, Muscle Strength, Muscle Strength Dynamometer, Sarcopenia

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