The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Selenium intake, status, and health: a complex relationship
Open accessAbstract
Both selenium (Se) deficiency and excess are found in natural locations throughout the world, though Se excess can also be caused by supplementation with Se. Both have been associated with adverse health effects that have often been characterized by a U-shaped relationship. Some health effects, such as increased mortality, are associated with both low and high Se status. Certain people and populations are better able to tolerate low or high Se intake than others; there are a number of possible explanations for this fact. Firstly, it may relate to the presence of polymorphisms (SNPs) in genes that improve the ability to deal with a low or high Se intake. Secondly, high Se status, with apparent absence of toxicity and even beneficial effects, can be found in populations exposed to toxic elements that are known to interact with Se, forming complexes in some cases. Thirdly, beneficial and harmful effects of Se depend on Se dose and form (speciation); for instance, at a high dose, selenomethionine (SeMet) has toxic effects that are mediated by metabolism to selenols/selenolates that can redox-cycle, generate superoxide radicals and react with thiols/diselenides to produce selenyl sulphides/disulphides. Finally, it is possible that exposure to a high Se intake from birth or from a very young age may alter the composition of the gut microbiota in such a way that excess Se is more readily excreted, thus reducing its toxicity.
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Cites
Rayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563
Self-citationLippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2009) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,122
Some drinking-water disinfectants and contaminants, including arsenic.
Anders, W. M., Bull, R. J., Cantor, K. P., Chakraborti, D., Chen, C., DeAngelo, A. B., DeMarini, D. M., Catterina Ferreccio, R., Fukushima, S., Gebel, T., et al. (2004) · PubMed · Cited by 1,000
Selenium, Selenoproteins, and Immunity
Avery, J., & Hoffmann, P. (2018) · Nutrients · doi:10.3390/nu10091203 · Cited by 894
Selenium in cancer prevention: a review of the evidence and mechanism of action
Rayman, M. P. (2005) · Proceedings of the Nutrition Society · doi:10.1079/pns2005467 · Cited by 858
Self-citationFood-chain selenium and human health: emphasis on intake
Rayman, M. P. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508939830 · Cited by 798
Self-citationStranges, S., Marshall, J. R., Natarajan, R., Donahue, R. P., Trevisan, M., Combs, G. F., Cappuccio, F. P., Ceriello, A., & Reid, M. E. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-4-200708210-00175 · Cited by 712
Some drinking-water disinfectants and contaminants, including arsenic.
(2004) · PubMed Central · Cited by 591
A liver-derived secretory protein, selenoprotein P, causes insulin resistance
Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583
Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys
Matović, V., Buha, A., Ðukić-Ćosić, D., & Bulat, Z. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.02.011 · Cited by 577
Cited by
Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review
Yang, Q., Liang, Q., Balakrishnan, B., Belobrajdic, D. P., Feng, Q.-J., & Zhang, W. (2020) · Nutrients · doi:10.3390/nu12020381 · Cited by 466
Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism
Köhrle, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043393 · Cited by 163
Huang, W., Song, J., Sun, T., He, Y., Li, X., Deng, Z., & Long, F. (2024) · Nature Communications · doi:10.1038/s41467-024-46065-6 · Cited by 17
Metadata
- Authors
- Rayman, M. P.
- Venue
- Hormones
- Published
- 2019-08-06
- Volume
- 19
- Issue
- 1
- Pages
- 9-14
- ISSN
- 1109-3099 (ISSN-L)
- 2520-8721
- OpenAlex
- W2965351710
- Cited by
- 441
- References
- 48
- FWCI
- 26.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
