Adhesion-enhancing coating embedded with osteogenesis-promoting PDA/HA nanoparticles for peri-implant soft tissue sealing and osseointegration
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This matrix remodeling guides cells to form fiber connections oriented perpendicular to the abutment surface, leading to a structurally compact and functionally competent soft tissue sealing zone.
“This matrix remodeling guides cells to form fiber connections oriented perpendicular to the abutment surface, ultimately leading to the establishment of a structurally compact and functionally competent soft tissue sealing zone.48”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [48]
In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.
“In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [48]
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“48 To further enhance the efficiency and specificity of soft tissue integration, researchers have taken advantage of the secondary reaction platform of PDA to immobilize cell-adhesive peptides on its surface, particularly arginine–glycine– aspartic acid (RGD) motifs.”
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- Authors
- Su, T., Zheng, A., Cao, L., Peng, L., Wang, X., Wang, J., Xin, X., & Jiang, X.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Jiang, Xinquan
- Venue
- Bio-Design and Manufacturing
- Published
- 2022-02-19
- Volume
- 5
- Issue
- 2
- Pages
- 233-248
- ISSN
- 2096-5524 (ISSN-L)
- 2522-8552
- OpenAlex
- W4213033479
- Cited by
- 25
- References
- 40
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 4 · 2022: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bio-Design and Manufacturing (publishedVersion)
- Funders
- national natural science foundation of china (81801006, 81901048, 81620108006, 81991505, 81921002, 81801023, 82100963)
- Shanghai Rising-Star Program (21QA1405400)
- the national key research and development program of china (2016YFC1102900)
- innovative research team of high-level local universities in shanghai (SSMU-ZDCX20180900)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Keywords
- polydopamine, hydroxyapatite nanoparticles, gelatin, osseointegration, cell adhesion, osteogenic differentiation, mesenchymal stem cells, antibacterial activity, Streptococcus mutans, anti-inflammatory activity, macrophages, gingival fibroblasts, implant surface modification
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