Quinoa and Chia Modulate AMPK/PPAR-ɣ Signaling in High-Fat Diet–Induced Obesity Rat Model
Open accessAbstract
Abstract Obesity is one of the principal reasons behind a wide range of metabolic diseases and dramatic health complications. Recent studies shed the light on chia ( Salvia hispanica L., Lamiaceae) and quinoa ( Chenopodium quinoa Willd., Amaranthaceae) seeds and identified them as products of utmost health benefits. The present study was designed to explore the molecular mechanisms of the hydroalcoholic extract of those seeds in weight management. Rats were divided randomly into two main groups: control and treated. The control groups received regular chow diet, high-fat diet, and green tea. The treated groups received high-fat diet and chia or quinoa extracts. Results revealed that the seeds showed hepatoprotective effects and anti-inflammatory and antioxidant activities, and modulated leptin, adiponectin, serum lipid, and glycemic profiles. Effects are further consolidated by normal hepatic tissue architecture upon histopathological examination. Moreover, modulation of peroxisome proliferator-activated receptors-γ transcriptional activity via activation of 5′AMP-activated protein kinase and suppression of nuclear expression of sterol regulatory element-binding protein-1c in obese rats as compared to green tea were demonstrated. Characterization of the major secondary bioactive metabolites was done using HPLC/PDA/ESI-MS/MS. Our study advocates evidence-based study on nutrition and health claims on the use of chia and quinoa extracts as nutraceutical supplements for promoting weight wellness and alleviating its related metabolic disorders.
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Quinoa extracts showed anti-obesity, antioxidant, hypoglycemic, immunoregulatory, and collagenase-modulating effects in in vivo experiments with rats.
“Quinoa extracts showed anti-obesity, antioxidant, hypoglycemic, immunoregulatory, and collagenase-modulating effects in in vivo experiments with rats [208,209,210,211,212,213,214].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [212]
The Glycemic Profile Improvement and Histopathological Alteration sections report reduced glucose, body weight, and oxidative-stress markers in obese rats given quinoa extract. The Anti-inflammatory Effect section reports reduced LT-B4, which supports an anti-inflammatory effect but not a broader immunoregulatory claim. No passage found in the copy supports collagenase modulation (searched: collagenase, collagen degradation, matrix metalloproteinase). (LLM, conf=0.87)
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Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
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“Supplementation with quinoa and chia seed extracts may regulate metabolic indicators and showed hepatoprotective, anti-inflammatory, and antioxidant activities in rats [212].”
Background
- Authors
- Omran, N. H., El-Bahy, A. A. Z., Hosny, H. T. A., & Handoussa, H.
- Affiliations
- University of Hertfordshire (GB)
- Future University in Egypt (EG)
- German University in Cairo (EG)
- Corresponding author
- Handoussa, Heba
- Venue
- Revista Brasileira de Farmacognosia
- Published
- 2023-04-12
- Volume
- 33
- Issue
- 3
- Pages
- 583-594
- ISSN
- 0102-695X (ISSN-L)
- 1981-528X
- OpenAlex
- W4365138044
- Cited by
- 17
- References
- 63
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Revista Brasileira de Farmacognosia (publishedVersion, cc-by)
- Greater South Information System
- Funders
- German University in Cairo
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- quinoa, chia, Salvia hispanica, high-fat diet-induced obesity, SREBP-1c, hepatoprotection, anti-inflammatory activity, antioxidant activity, leptin, adiponectin, serum lipids, glycemic profile, nutraceuticals, weight management, bioactive metabolites
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