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The Framingham Offspring Study: a commentary1150th AnniversaryHistorical ArticleINTRODUCTIONIn this edition of the Journal, we release the fifth in a series of reviews of influential articles that have been previously published in ACC journals, including the American Journal of Cardiology(from 1958 to 1982) and JACC(from 1983 to the present). The publication of these articles is only one aspect of the ACC’s 50th anniversary commemoration, which highlights 50 years of leadership in cardiovascular care and education. The articles are intended to encourage reflection on the remarkable progress made in cardiovascular medicine over time, as well as to acknowledge the amazing prescience of some early investigators in anticipating and, in many cases, later guiding developments in their field.The working group responsible for selecting these articles and asking reviewers to write editorials solicited suggestions from the ACC’s clinical committees and individual members.The group achieved consensus fairly easily, including whom the group should ask to prepare the accompanying editorials. We initially drew up a list of 14 general areas to cover in this series, but later found that there are several major areas of modern cardiology, prominently molecular cardiology, in which the truly landmark articles have, alas, not yet been published in JACC. Therefore, the working group decided not to categorize by subject, but instead, to concentrate on the most important articles.The working group, a task force of the Subcommittee for the Commemoration of the ACC 50th Anniversary, owes a great deal to Ms. May A. Roustom and the efficient and tireless staff at Heart House for facilitating this project. We also wish to thank all who suggested articles and, most important, the authors who prepared reviews for their willingness to contribute their time and wisdom.Influential Articles in JACC Working GroupSharon A. Hunt, M.D., F.A.C.C.Rick A. Nishimura, M.D., F.A.C.C.H.J.C. Swan, M.D., Ph.D., M.A.C.C.Michael J. Wolk, M.D., F.A.C.C.

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Lessons from curbing the coronary artery disease epidemic for confronting the impending epidemic of heart failure

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Noninvasive detection of coronary artery disease--challenges for prevention of disease and clinical events

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Mortality in patients with myocardial infarction and potential risk factors: A five-year data analysis.

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Improvement in Stroke Risk Prediction: Role of C-Reactive Protein and Lipoprotein-Associated Phospholipase A 2 in the Women's Health Initiative

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Metabolic effects of a very low calorie diet in obese children and adolescents with special reference to nitrogen balance.

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THE IMPORTANT ROLE OF FITNESS DETERMINATION AND STRESS TESTING IN PREDICTING CORONARY INCIDENCE

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A Conceptual and Historical Framework for Molecular Epidemiology

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Atherosclerosis: Biological and Surgical Considerations

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Framework for Evaluating Novel Risk Markers

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Cardiovascular risk assessment according to the Framingham score and abdominal obesity in individuals seen by a clinical school of nutrition

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Generation of Knowledge for Clinical Decision Support

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CHD Risk Minimization through Lifestyle Control: Machine Learning Gateway

He, X., Matam, B. R., Bellary, S., Ghosh, G., & Chattopadhyay, A. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-60786-w · Cited by 11

Cost-effectiveness analysis of antihypertensive triple combination therapy among patients enrolled in a Medicare advantage plan

Wang, X., Chen, H., Essien, E. J., Wu, J., Serna, O., Paranjpe, R., & Abughosh, S. (2020) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1080/14737167.2020.1800457 · Cited by 14

Prevalence of Coronary Artery Disease in Rural Areas of Peshawar

Hassan, M. U., Awan, Z. A., Gul, A. M., Sahibzada, W. A., & Hafizullah, M. (2005) · Journal of Postgraduate Medical Institute · Cited by 12

Survival Rate and its Related Factors in Patients with Acute Myocardial Infarction

Ehsan, M. F., Baneshi, M. R., & Zolala, F. (2014) · مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد · Cited by 12

Risk Factors of Atherosclerosis

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Present and Future Role of Combination Treatment in Hypertension

Mancia, G., Failla, M., Grappiolo, A., & Giannattasio, C. (1998) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199800002-00007 · Cited by 12

Design issues in the combination of international data from two rural community cardiovascular intervention programs

Nafziger, A. N., Weinehall, L., Lewis, C. B., Jenkins, P., Erb, T. A., Pearson, T. A., & Wall, S. (2001) · Scandinavian Journal of Public Health · doi:10.1080/140349401316898117 · Cited by 12

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Terry, M. L., Berkowitz, H. D., Kerstein, M. D., & FACS (1998) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70323-6 · Cited by 11

The aging of the cardiovascular system: When should children be treated like adults?

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White-Coat Hypertension—To Treat or Not to Treat

Moser, M. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.22.2655 · Cited by 12

Metabolic syndrome as an indicator of high cardiovascular risk in patients with diabetes: Analyses based on Korea National Health and Nutrition Examination Survey (KNHANES) 2008

Rhee, S. Y., Park, S. Y., Hwang, J. K., Son, J. I., Chin, S. O., Kim, Y. S., & Woo, J. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-98 · Cited by 11

Deintensification or No Statin Treatment Is Associated With Higher Mortality in Patients With Ischemic Stroke or Transient Ischemic Attack

Dearborn, J. L., Hu, X. Y., Bravata, D. M., Phadke, M. A., Baye, F. M., Myers, L. J., Concato, J., Zillich, A. J., Reeves, M. J., & Sico, J. J. (2021) · Stroke · doi:10.1161/strokeaha.120.030089 · Cited by 11

Prevalence of traditional and non-traditional cardiovascular risk factors in adults with congenital heart disease

Levene, J., Cambron, C., McGrath, L. B., Colina, I., Broberg, C. S., Ramsey, K., & Khan, A. M. (2022) · International Journal of Cardiology Congenital Heart Disease · doi:10.1016/j.ijcchd.2022.100424 · Cited by 11

Increased arterial pressure volume index and cardiovascular risk score in China

Jin, L., Zhang, M., Sha, L., Cao, M., Tong, L., Chen, Q., Shen, C., Du, L., Liu, L., & Li, Z. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-03035-4 · Cited by 11

Absolute cardiovascular risk and GP decision making in TIA and minor stroke

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Utilization of who-ish 10-year cvd risk prediction chart as a screening tool among supporting staff of a tertiary care hospital, Mysuru, India

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Demonstration of the Glagov phenomenon in vivo by CT coronary angiography in subjects with elevated Framingham risk

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APOLIPOPROTEIN A‐I AND B LEVELS IN ADOLESCENTS; A TRIAL TO DEFINE SUBJECTS AT RISK FOR CORONARY HEART DISEASE

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