Cited by 1,189Health Promotion and Cardiovascular PreventionCardiovascular Health and Risk FactorsLipoproteins and Cardiovascular Health

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A general cardiovascular risk profile: The Framingham study

Kannel, William B., McGee, Daniel, Gordon, Tavia·1976·The American Journal of Cardiology

DOI 10.1016/0002-9149(76)90061-8

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Abstract

Persons at high risk of cardiovascular disease can be effectively identified from a measurement of their serum cholesterol and blood pressure, a smoking history, an electrocardiogram and a determination of glucose intolerance. One general function for identifying persons at high risk of cardiovascular disease is also effective in identifying persons at risk for each of the specific diseases, coronary heart disease, atherothrombotic brain infarction, hypertensive heart disease and intermittent claudication, even though the variables used have a different impact on each particular disease. The 10 percent of persons identified with use of this function as at highest risk accounted for about one fifth of the 8 year incidence of coronary heart disease and about one third of the 8 year incidence of atherothrombotic brain infarction, hypertensive heart disease and intermittent claudication. Hence the function provides an economic and efficient method of identifying persons at high cardiovascular risk who need preventive treatment and persons at low risk who need not be alarmed about one moderately elevated risk characteristic.

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Self-citation
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1970, Circulation, 42, A-55

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Authors: Kannel, W. B., McGee, D., & Gordon, T.
Affiliations: National Institutes of Health (US)
Corresponding author: Kannel, William B.
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 1976-07
Volume: 38
Issue: 1
Pages: 46-51
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/0002-9149(76)90061-8
OpenAlex: W2031564429
Cited by: 1,189
References: 3
Citations by year: 2026: 18 · 2025: 30 · 2024: 29 · 2023: 37 · 2022: 31 · 2021: 27 · 2020: 37 · 2019: 30 · 2018: 31 · 2017: 42 · 2016: 36 · 2015: 38 · 2014: 52 · 2013: 48 · 2012: 29
FWCI: 21.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: cardiovascular risk profile, coronary artery disease, atherothrombotic brain infarction, hypertensive heart disease, intermittent claudication, serum cholesterol, blood pressure, smoking history, electrocardiogram, impaired glucose tolerance, risk function, disease incidence, prophylaxis
MeSH terms: Adult, Age Factors, Aged, Cardiovascular Diseases, Female, Cardiomegaly, Humans, Hypercholesterolemia, Hypertension, Life Style, Male, Massachusetts, Middle Aged, Obesity, Probability, Regression Analysis, Risk, Sex Factors, Smoking, Diabetes Complications

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A general cardiovascular risk profile: The Framingham study

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