Cited by 47Cardiovascular Health and Risk FactorsCardiac Imaging and DiagnosticsDiabetes, Cardiovascular Risks, and Lipoproteins

Importance of risk factors in the angiographic progression of coronary artery disease

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Raichlen, Joel S., Healy, Bernadine, Achuff, Stephen C., Pearson, Thomas A.·1986·The American Journal of Cardiology

Abstract

Although specific risk factors correlate with the development of clinical coronary events, little is known about their importance in patients with established coronary artery disease (CAD). A numerical scoring system was used to assess serial coronary angiograms in subjects who had detailed risk factor determinations. Strong linear correlations were demonstrated between the extent of progression of CAD and diastolic blood pressure (BP) (p = 0.002), systolic BP (p = 0.094), the number of cigarette pack-years smoked among current smokers (p = 0.022), fasting blood glucose level (p = 0.017) and low levels of physical activity at leisure (p = 0.097). This analysis of sequential coronary angiograms identifies BP, cigarette smoking, diabetes mellitus and physical activity as important risk factors in the progression of CAD. These variables merit attention in the management of patients with symptomatic CAD and in secondary coronary prevention trials investigating risk factor modification.

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Authors
Raichlen, J. S., Healy, B., Achuff, S. C., & Pearson, T. A.
Affiliations
Johns Hopkins University (US)
Corresponding author
Pearson, Thomas A.
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1986-01
Volume
57
Issue
1
Pages
66-70
ISSN
0002-9149 (ISSN-L)
OpenAlex
W2022868265
Cited by
47
References
27
Citations by year
2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2014: 1 · 2012: 2
FWCI
3.29
Type
journal article
Language
en
Open access
Locations
  • The American Journal of Cardiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p50hl017655-17, HL-07227)
  • National Heart, Lung, and Blood Institute (P50-HL-17655-07, 2-T32-HL-07227, T32HL007227)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
coronary artery disease progression, cardiovascular risk factors, diastolic blood pressure, systolic blood pressure, cigarette smoking, pack-years, fasting blood glucose, diabetes mellitus, physical activity, risk factor scoring, secondary prevention
MeSH terms
Adult, Aged, Angiography, Blood Glucose, Blood Pressure, Coronary Disease, Evaluation Studies as Topic, Physical Exertion, Female, Humans, Hypertension, Male, Middle Aged, Risk, Smoking, Coronary Angiography, Diabetes Complications

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