Importance of risk factors in the angiographic progression of coronary artery disease
Open accessAbstract
Although specific risk factors correlate with the development of clinical coronary events, little is known about their importance in patients with established coronary artery disease (CAD). A numerical scoring system was used to assess serial coronary angiograms in subjects who had detailed risk factor determinations. Strong linear correlations were demonstrated between the extent of progression of CAD and diastolic blood pressure (BP) (p = 0.002), systolic BP (p = 0.094), the number of cigarette pack-years smoked among current smokers (p = 0.022), fasting blood glucose level (p = 0.017) and low levels of physical activity at leisure (p = 0.097). This analysis of sequential coronary angiograms identifies BP, cigarette smoking, diabetes mellitus and physical activity as important risk factors in the progression of CAD. These variables merit attention in the management of patients with symptomatic CAD and in secondary coronary prevention trials investigating risk factor modification.
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Prior studies have observed an association between diabetes and angiographic progression of coronary atherosclerosis.
“Prior studies have observed the association between diabetes and angiographic progression of coronary atherosclerosis.18 -22”
From Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women (2006) · cites this paper as [21]
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- Authors
- Raichlen, J. S., Healy, B., Achuff, S. C., & Pearson, T. A.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Pearson, Thomas A.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1986-01
- Volume
- 57
- Issue
- 1
- Pages
- 66-70
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2022868265
- Cited by
- 47
- References
- 27
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2014: 1 · 2012: 2
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The American Journal of Cardiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p50hl017655-17, HL-07227)
- National Heart, Lung, and Blood Institute (P50-HL-17655-07, 2-T32-HL-07227, T32HL007227)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- coronary artery disease progression, cardiovascular risk factors, diastolic blood pressure, systolic blood pressure, cigarette smoking, pack-years, fasting blood glucose, diabetes mellitus, physical activity, risk factor scoring, secondary prevention
- MeSH terms
- Adult, Aged, Angiography, Blood Glucose, Blood Pressure, Coronary Disease, Evaluation Studies as Topic, Physical Exertion, Female, Humans, Hypertension, Male, Middle Aged, Risk, Smoking, Coronary Angiography, Diabetes Complications
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