Cited by 350Coronary Interventions and DiagnosticsCardiac Imaging and DiagnosticsCardiac and Coronary Surgery Techniques

Five-year angiographic follow-up of factors associated with progression of coronary artery disease in the Coronary Artery Surgery Study (CASS)

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Alderman, Edwin L., Corley, Scott D., Fisher, Lloyd D., Chaitman, Bernard R., Faxon, David P., Foster, Eric D., Killip, Thomas, Sosa, Julio A. +1 more·1993·Journal of the American College of Cardiology

Abstract

Objectives The Coronary Artery Surgery Study (CASS) required participants to undergo follow-up angiography at 5 years to identify clinical and angiographic features associated with progression of coronary artery disease.Background The CASS randomized 780 patients at 11 participating clinical centers between an initial strategy of medical therapy versus bypass surgery. Five clinical sites accomplished follow-up angiography in > 50% of their randomized subjects within a 42- to 66-month period after the entry arteriogram (n = 314).Methods Qualified clinical site angiographers, using side by side film review, evaluated an average of 13 segments/patient on both arteriograms for initial stenosis severity, morphologic features, lesion location and occurrence of disease progression or occlusion. Progression was defined as further definite narrowing by > or = 15% and occlusion as lesion progression to > or = 98%. Lesions were subcategorized as to whether they were univariate and had or had not been treated with bypass surgery. Multivariate logistic regression analyses were performed.Results For nonbypassed segments, right coronary artery and left anterior descending artery proximal and midlocations were associated with disease progression. For stenosis-containing segments, the initial severity, a non-left anterior descending artery location and increased treadmill duration predicted progression. Segment occlusion was associated with initial lesion severity, right coronary artery location and subsequent interval myocardial infarction. There were few predictors of progression or occlusion in bypassed arteries, other than initial lesion severity.Conclusions Univariate and multivariate associations with lesion progression and occlusion included diabetes, lesion location, elevated cholesterol level, interval infarction and lesion morphology. These angiographic results, collected in a prospective trial, are consistent with known risk factors.

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  1. Kramer JR. Matsuda Y . Muiligan JC . Aronow M. Proudlit WL Progres- sion of coronary atherosclerosis . Circulation 1981 ;63 :519-26 .

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Authors
Alderman, E. L., Corley, S. D., Fisher, L. D., Chaitman, B. R., Faxon, D. P., Foster, E. D., Killip, T., Sosa, J. A., & Bourassa, M. G.
Affiliations
University of Washington (US)
Corresponding author
Alderman, Edwin L.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
1993-10
Volume
22
Issue
4
Pages
1141-1154
ISSN
0735-1097 (ISSN-L)
OpenAlex
W2075105091
Cited by
350
References
21
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 3 · 2014: 11 · 2013: 7 · 2012: 21
FWCI
9.02
Type
journal article
Language
en
Open access
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
Keywords
coronary artery disease progression, Coronary Artery Surgery Study, coronary angiography, lesion localization, right coronary artery, left anterior descending artery, lesion severity, diabetes mellitus, cholesterol, coronary artery bypass grafting, risk factors
MeSH terms
Coronary Artery Bypass, Coronary Disease, Female, Follow-Up Studies, Graft Occlusion, Vascular, Humans, Hypercholesterolemia, Male, Middle Aged, Myocardial Infarction, Postoperative Complications, Predictive Value of Tests, Prognosis, Prospective Studies, Recurrence, Risk Factors, Severity of Illness Index, Observer Variation, Logistic Models, Coronary Angiography, Diabetes Complications

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