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Cited by 80Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismDiabetes, Cardiovascular Risks, and Lipoproteins

Effect of a modified, well-tolerated niacin regimen on serum total cholesterol, high density lipoprotein cholesterol and the cholesterol to high density lipoprotein ratio

Alderman, James D., Pasternak, Richard C., Sacks, Frank M., Smith, Harton S., Monrad, E.Scott, Grossman, William·1989·The American Journal of Cardiology
DOI 10.1016/0002-9149(89)90754-6
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Abstract

One hundred one patients with coronary artery disease and pretreatment ratios of total cholesterol to high density lipoprotein (HDL) cholesterol greater than 4.0 were treated with niacin, commencing at low dosages (100 to 250 mg twice daily) and gradually increasing the dosage over 4 to 8 weeks to 1,000 mg twice daily. Dosage adjustments were made to minimize side effects. At a mean follow-up duration of 11 +/- 7 months, and a mean dosage of 1,415 +/- 698 mg/day, the group had a 13% reduction in total cholesterol, 31% increase in HDL and 32% decrease in the cholesterol to HDL ratio. A subgroup of 62 patients taking greater than 1,000 mg/day of niacin had an 18% reduction in total cholesterol, 32% increase in HDL and 36% improvement in the cholesterol to HDL ratio. A subgroup of 39 patients taking less than or equal to 1,000 mg/day of niacin had only a 5% reduction in total cholesterol, although a 29% increase in HDL and a 24% decrease in the cholesterol to HDL ratio were recorded. Side effects of niacin were reported in 38% of the patients, but led to discontinuation of therapy in only 4. Niacin can be administered in a fashion that is well tolerated, inexpensive and very effective in improving the cholesterol to HDL ratio.

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Crossref · 10.1016/0002-9149(89)90754-6

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Authors
Alderman, J. D., Pasternak, R. C., Sacks, F. M., Smith, H. S., Monrad, E. S., & Grossman, W.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Pasternak, Richard C.
ORCID
Sacks, Frank M.
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1989-10
Volume
64
Issue
12
Pages
725-729
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(89)90754-6
OpenAlex
W2072615103
Cited by
80
References
30
Citations by year
2023: 1 · 2019: 1 · 2018: 1 · 2013: 1 · 2012: 2
FWCI
10.37
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
nicotinic acid, TC/HDL-C ratio, HDL cholesterol, total cholesterol, coronary artery disease, lipid-lowering therapy
MeSH terms
Adult, Aged, Cholesterol, Coronary Disease, Female, Humans, Lipoproteins, HDL, Cholesterol, HDL, Male, Middle Aged, Niacin, Prospective Studies

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