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Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (the Bogalusa Heart Study)
Abstract
Race and sex differences in aorta and coronary atherosclerotic lesions were studied in 150 persons aged 6 to 30 years. The intimal surface involvement with aorta fatty streaks was extensive, 0 to 71%, and greater in blacks than in whites (32 vs 20%, p less than 0.001). Coronary artery fatty streaks were more extensive in male than in female subjects (range 0 to 22%). Fibrous plaque lesions were present but not extensive in either the aorta (0 to 12%) or the coronary artery (0 to 24%) specimens. Lesions were more prevalent in male than in female persons, particularly white male subjects. The relation of fatty streaks to fibrous plaques was greater in the coronary vessels than in the aorta. In male subjects, aorta fatty streaks were strongly related to antemortem levels of total cholesterol, low-density lipoprotein cholesterol and ponderal index in white male subjects. Coronary artery fatty streaks in white male persons were significantly associated with serum triglycerides, very low density lipoprotein cholesterol, systolic and diastolic blood pressure and ponderal index. These results link antemortem risk factors to the development of atherosclerotic lesions and emphasize the need for preventive cardiology in early life.
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“atherosclerotic fatty streaks in the coronary arteries, indicative of coronary heart disease, have been found in overweight adolescents (Haque 2008), and postmortem in children (Berenson 1992).”
From School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18 (2013) · cites this paper as Berenson 1992
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Metadata
- Authors
- Berenson, G. S., Wattigney, W. A., Tracy, R. E., Newman, W. P., Srinivasan, S. R., Webber, L. S., Dalferes, E. R., & Strong, J. P.
- Affiliations
- Tulane University (US)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 70
- Issue
- 9
- Pages
- 851-858
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W1974698688
- Cited by
- 591
- References
- 31
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 2 · 2023: 13 · 2022: 14 · 2021: 11 · 2020: 11 · 2019: 20 · 2018: 13 · 2017: 22 · 2016: 16 · 2015: 15 · 2014: 15 · 2013: 20 · 2012: 24
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01hl038844-06)
- National Heart, Lung, and Blood Institute (5R01-HL38844)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- atherosclerosis, aorta, coronary arteries, fatty streaks, fibrous plaque, cardiovascular risk factors, racial differences, sex differences, young adults, total cholesterol, LDL cholesterol, triglycerides, blood pressure, ponderal index, Bogalusa Heart Study, preventive cardiology
- MeSH terms
- Adolescent, Adult, Age Factors, Aorta, Aortic Diseases, Arteriosclerosis, Autopsy, Cardiovascular Diseases, Child, Coronary Artery Disease, Coronary Vessels, Female, Humans, Lipids, Lipoproteins, Male, Risk Factors, Sex Factors, Black People
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