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Cited by 50Pancreatic function and diabetesDiabetes Treatment and ManagementGrowth Hormone and Insulin-like Growth Factors

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Somatostatin and diabetes

Gerich, John E.·1981·The American Journal of Medicine
DOI 10.1016/0002-9343(81)90584-2
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Abstract

Somatostatin, a tetradecapeptide originally isolated from the hypothalamus on the basis of its ability to inhibit the secretion of growth hormone, is now known to be widely distributed in various endocrine and gastrointestinal tissues and to have diverse actions, including inhibition of insulin and glucagon secretion. The location of somatostatin in pancreatic islet D cells suggests that it may act as a local regulator of insulin and glucagon secretion. Changes in islet D-cell function in experimentally-induced and spontaneous diabetes in animals suggest that the peptide may be involved in the pathogenesis of diabetes. Clinical studies with the peptide have provided insight into the physiologic roles of glucagon and growth hormone, and have indicated a potential therapeutic use for somatostatin in diabetes in man.

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Metadata

Authors
Gerich, J. E.
Corresponding author
Gerich, John E.
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
1981-03
Volume
70
Issue
3
Pages
619-626
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/0002-9343(81)90584-2
OpenAlex
W2042418892
Cited by
50
References
3
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2016: 1 · 2015: 1 · 2012: 1
FWCI
0.49
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
somatostatin, diabetes mellitus, insulin secretion, glucagon secretion, growth hormone secretion, diabetes pathogenesis, somatostatin therapy, hypothalamus
MeSH terms
Insulin Secretion, Diabetes Mellitus, Glucagon, Glucose, Homeostasis, Hormones, Ectopic, Humans, Insulin, Islets of Langerhans, Pancreatic Neoplasms, Somatostatin

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