Insulin resistance in noninsulin-dependent diabetes mellitus
Abstract
Several techniques that have been used to quantify in vivo insulin-stimulated glucose uptake in patients with noninsulin-dependent diabetes mellitus (NIDDM) have been critically reviewed. An attempt has been made to outline both the advantages and disadvantages of the specific approaches, as well as to summarize the results of the application of these methods in assessment of insulin action in patients with NIDDM. Although th details of the techniques that have been used vary considerably, the results obtained with all of them are quite consistent, and demonstrate unequivocally that the ability of insulin to stimulate glucose utilization is markedly reduced in patients with NIDDM.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Development of techniques to measure insulin-mediated glucose disposal allowed direct confirmation of insulin resistance in individuals matching a noninsulin-dependent diabetes phenotype.
“In parallel, development of techniques to measure insulin-mediated glucose disposal allowed for direct confirmation of insulin resistance in individuals matching a noninsulin-dependent diabetes phenotype39–41.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [40]
Cites
Ginsberg, H., Kimmerling, G., Olefsky, J. M., & Reaven, G. M. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107951 · Cited by 225 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works
Self-citationEarly Metabolic Defects in Persons at Increased Risk for Non-Insulin-Dependent Diabetes Mellitus
Eriksson, J., Franssila-Kallunki, A., Ekstrand, A., Saloranta, C., Widén, E., Schalin, C., & Groop, L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908103210601 · Cited by 807 · see citing works
Phillips, D. I. W., Clark, P. M., Hales, C. N., & Osmond, C. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00273.x · Cited by 631 · see citing works
REAVEN, G. M., CHEN, Y.-D. I., GOLAY, A., SWISLOCKI, A. L. M., & JASPAN, J. B. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-106 · Cited by 326 · see citing works
Self-citationThe disposal of an oral glucose load in patients with non-insulin-dependent diabetes
Ferrannini, E., Simonson, D. C., Katz, L. D., Reichard, G., Bevilacqua, S., Barrett, E. J., Olsson, M., & DeFronzo, R. A. (1988) · Metabolism · doi:10.1016/0026-0495(88)90033-9 · Cited by 305 · see citing works
100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
Lee, Y.-S., Shin, S., Shigihara, T., Hahm, E., Liu, M.-J., Han, J., Yoon, J.-W., & Jun, H.-S. (2007) · Diabetes · doi:10.2337/db06-1182 · Cited by 158 · see citing works
Insulin Resistance, Type 2 Diabetes Mellitus, and Cardiovascular Disease: The End of the Beginning
Reaven, G. (2005) · Circulation · doi:10.1161/circulationaha.105.504670 · Cited by 98 · see citing works
Viscoli, C. M., Brass, L. M., Carolei, A., Conwit, R., Ford, G. A., Furie, K. L., Gorman, M., Guarino, P. D., Inzucchi, S. E., Lovejoy, A. M., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.07.016 · Cited by 50 · see citing works
- Authors
- Reaven, G. M.
- Corresponding author
- Reaven, Gerald M.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1983-01
- Volume
- 74
- Issue
- 1
- Pages
- 3-17
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W1966556968
- Cited by
- 154
- References
- 1
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 3
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- insulin resistance, type 2 diabetes, insulin-stimulated glucose uptake, insulin action, glucose utilization
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Methods, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
