Insulin Resistance, Type 2 Diabetes Mellitus, and Cardiovascular Disease: The End of the Beginning
Abstract
n his 1939 Goulstonian Lectures to the Royal College of Physicians in London, Harold Himsworth addressed the "Mechanisms of Diabetes."In the course of these 3 presentations, 1-3 he provided evidence that "diabetes mellitus is a disease in which the essential lesion is a diminished ability of the tissue to utilize glucose.The high blood sugar is a controlled and compensatory phenomenon, the object of which is to facilitate the utilization of glucose by the tissues."In addition, he challenged the conventional wisdom that "all causes of human diabetes could be explained by deficiency of insulin" and went on to utter the heretical notion that "a state of diabetes might result from inefficient action of insulin as well as from a lack of insulin."Thus, the notion of a causal role of insulin resistance in human disease was born almost 70 years ago.
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The most frequent modifiable determinant of insulin resistance and hyperinsulinemia is adiposity.
“The most frequent modifiable determinant of insulin resistance and hyperinsulinemia is adiposity (Reaven, 2005; Reaven and Laws, 1999), although adipose tissue is not the only factor.”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Reaven, 2005
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Research works printed but not linked: 3
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- Authors
- Reaven, G.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Reaven, Gerald
- Venue
- Circulation
- Published
- 2005-11-15
- Volume
- 112
- Issue
- 20
- Pages
- 3030-3032
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2127151873
- Cited by
- 98
- References
- 28
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 7 · 2013: 4 · 2012: 5
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- insulin resistance, type 2 diabetes, cardiovascular disease, cardiovascular risk
- MeSH terms
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Insulin Resistance, Risk Assessment, Metabolic Syndrome
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