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Cited by 323Systemic Lupus Erythematosus ResearchRheumatoid Arthritis Research and TherapiesCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Effect of prednisone and hydroxychloroquine on coronary artery disease risk factors in systemic lupus erythematosus: A longitudinal data analysis

Petri, Michelle, Lakatta, Christiana, Magder, Laurence, Goldman, Daniel·1994·The American Journal of Medicine
DOI 10.1016/0002-9343(94)90151-1
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Abstract

Purpose To determine the effect of prednisone dose and hydroxychloroquine dose on the coronary artery disease risk factors serum cholesterol level, mean arterial blood pressure, and weight in patients with systemic lupus erythematosus.Patients and methods A longitudinal cohort study of 264 patients with systemic lupus erythematosus was conducted. For all patients in the cohort, serum cholesterol, mean arterial pressure, weight, prednisone dose, hydroxychloroquine dose, and other potential confounding variables were recorded at each visit. Regression analysis appropriate for longitudinal data was used to assess the effect of prednisone on serum cholesterol and mean arterial pressure. To assess the effect of prednisone on weight, patients' weights were compared 90 days before and after a 10-mg or 20-mg increase in prednisone.Results A total of 3,027 patient visits were analyzed. In the regression model for serum cholesterol, a change in prednisone dose of 10 mg was associated with a change in cholesterol of 7.5 +/- 1.46 (SE) mg% after adjustment for the other significant variables in the model, including sex, race, hydroxychloroquine dose, and proteinuria. In the regression model for hydroxychloroquine, the 200-mg and the 400-mg dose were both associated with lower serum cholesterol (8.9 +/- 3.44 SE mg%). In the regression model for mean arterial blood pressure, a 10-mg change in prednisone dose led to a change in mean arterial blood pressure of 1.1 mm Hg after adjustment for age, weight, and antihypertensive drug use. A 10-mg increase in prednisone dose was associated with a mean weight change of 5.50 +/- 1.23 (SE) lb.Conclusions Changes in prednisone dose led to definable changes in risk factors for coronary artery disease, even after adjustment for other variables known to affect these risk factors. According to longitudinal regression analysis, hydroxychloroquine therapy was associated with lower serum cholesterol.

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Research works printed but not linked: 2

  1. Cumming, 1989, Cardiovascular disease-related knowledge and attitudes in a high-risk Australian population, Med J Aust, 150, 556, 10.5694/j.1326-5377.1989.tb136692.x · DOI
  2. Bush, 1988, Cholesterol, lipoproteins, and coronary heart disease in woman, Clin Chem, 34, B60

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Metadata

Authors
Petri, M., Lakatta, C., Magder, L., & Goldman, D.
Affiliations
Johns Hopkins University (US)
Corresponding author
Petri, Michelle
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
1994-03
Volume
96
Issue
3
Pages
254-259
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/0002-9343(94)90151-1
OpenAlex
W2021741488
Cited by
323
References
25
Citations by year
2026: 5 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 14 · 2016: 6 · 2015: 6 · 2014: 16 · 2013: 15 · 2012: 23
FWCI
2.88
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29hl047080-02)
  • National Heart, Lung, and Blood Institute (HL 47080-01)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
systemic lupus erythematosus, prednisone, hydroxychloroquine, coronary risk factors, serum cholesterol, mean arterial pressure, body weight, glucocorticoid dose, hypolipidemic effect
MeSH terms
Adult, Blood Pressure, Body Weight, Cholesterol, Coronary Disease, Female, Humans, Hydroxychloroquine, Lupus Erythematosus, Systemic, Male, Middle Aged, Prednisone, Regression Analysis, Risk Factors, Linear Models

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