Use of intranasal oxytocin in obstetrics
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In Hoover's study of 1,806 women, intranasal oxytocin augmented labor at 1-4 doses of 0.4-0.8 IU every 20 minutes (maximum 3.2 IU); equivalent effects from intravenous infusion of 1-2 mU/min led to an estimate that about 1% of intranasally applied oxytocin enters the circulation.
“Hoover studied 1,806 women who had been given intranasal oxytocin during childbirth (31).Labor was stimulated by 1-4 doses of 0.4-0.8IUgiven at 20-min intervals -a total of, at most, 3.2IU.Equivalent effects were achieved by intravenous infusion of 1-2mU/min, giving rise to the estimate that ~1% of intranasally-applied oxytocin enters the circulation (32).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [32]
Cites
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Self-citationStudien �ber die Uterusmotilit�t Me�methode ? Testung der Wehenbereitschaft
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Intranasal Oxytocin: Myths and Delusions
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- Authors
- Hendricks, C. H., & Gabel, R. A.
- Affiliations
- Case Western Reserve University (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1960-04
- Volume
- 79
- Issue
- 4
- Pages
- 780-788
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1623521581
- Cited by
- 33
- References
- 7
- Citations by year
- 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 18.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- intranasal oxytocin, synthetic oxytocin, uterine contractility, labor induction, pregnancy, uterine activity monitoring
- MeSH terms
- Obstetrics, Oxytocin
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