Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer.

Judd, Howard L.; Lucas, William E.; Yen, Samuel S.C.

doi:10.1016/0002-9378(74)90490-6

Cited by 263Estrogen and related hormone effectsEndometrial and Cervical Cancer TreatmentsOvarian function and disorders

Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer.

Judd, Howard L., Lucas, William E., Yen, Samuel S.C.·1974·American Journal of Obstetrics and Gynecology

DOI 10.1016/0002-9378(74)90490-6

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Peripheral serum testosterone decreases by 50% after ovariectomy in postmenopausal women, indicating that the approximately equal contribution of the ovaries and adrenals to serum testosterone remains after menopause.
“Peripheral serum testosterone decreases by 50% after ovariectomy in postmenopausal women, thus indicating that the approximately equal contribution of the ovaries and adrenals to serum testosterone remains after menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [158]
The ovaries and adrenals contribute about equally to the serum levels of 4-dione in premenopausal women.
“although the ovaries and adrenals contribute about equally to the serum levels of 4-dione in premenopausal women (158, 159),”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [158]
The contribution of the ovaries to serum 4-dione decreases to about 20% after menopause.
“the contribution of the ovaries decreases to about 20% after menopause (158, 159),”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [158]

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Authors: Judd, H. L., Lucas, W. E., & Yen, S. S. C.
Affiliations: Naval Medical Center San Diego (US)
Corresponding author: Judd, Howard L.
ORCID: Lucas, William E.
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 1974-03
Volume: 118
Issue: 6
Pages: 793-798
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/0002-9378(74)90490-6
OpenAlex: W1715563854
Cited by: 261
References: 26
Citations by year: 2026: 5 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 5 · 2014: 5 · 2013: 9 · 2012: 5
FWCI: 3.95
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: oophorectomy, endometrial cancer, serum testosterone, androstenedione, ovarian hormone secretion, menopause, premenopausal women, postmenopausal women, androgen levels
MeSH terms: Adenocarcinoma, Adult, Aged, Androstenedione, Castration, Curettage, Estrogens, Fallopian Tubes, Female, Humans, Hysterectomy, Medroxyprogesterone, Menopause, Metabolic Clearance Rate, Middle Aged, Ovary, Radioimmunoassay, Testosterone, Uterine Neoplasms

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Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer.

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