The hormonal activity of the postmenopausal ovary.

VERMEULEN, A.

doi:10.1210/jcem-42-2-247

Cited by 379Ovarian function and disordersEstrogen and related hormone effectsAdrenal Hormones and Disorders

The hormonal activity of the postmenopausal ovary.

VERMEULEN, A.·1976·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-42-2-247

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Abstract

The origin of plasma sex hormones in postmenopausal women was studied by determining plasma levels under basal conditions, after ACTH stimulation, and after dexamethasone suppression, as well as after hCG stimulation. Values obtained in postmenopausal women were compared with values observed during the follicular phase of the cycle in young women on the one hand, and with values in ovariectomized women of postmenopausal age on the other hand. All sex steroid levels studied with the exception of estrone, were significantly lower in postmenopausal women than in young women during the early follicular phase of the cycle. In ovariectomized women only androgen levels (testosterone, androstenedione, dihydrotestosterone, and to a lesser extent dehydroepiandrosterone,) were lower than in normal postmenopausal women, estrogen, 17 hydroxyprogesterone, and progesterone levels being similar. ACTH increased all plasma steroid levels except estradiol, whereas after dexamethasone, all sex hormone levels were significantly decreased. hCG stimulation finally caused an increase of borderline statistical significance in testosterone, dehydroepiandrosterone, and 17-hydroxyprogesterone levels. We have concluded from this study that the adrenal cortex is almost the exclusive source of plasma estradiol, estrone, progesterone, and 17OH progesterone and the most important source of plasma dehydroepiandrosterone; that the postmenopausal ovary appears to be responsible for about 50% of plasma testosterone and 30% of androstenedione levels; and that hCG stimulation with 5000 IU daily for 3 days, hardly influences steroid secretion by postmenopausal ovaries.

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In another study, hCG stimulation and dexamethasone suppression tests in postmenopausal women have suggested that the ovary contributes about 50% of testosterone and 30% of 4-dione in the peripheral circulation.
“In another study, human chorionic gonadotrophin stimulation and dexamethasone suppression tests in postmenopausal women have suggested that the ovary contributes about 50% of testosterone and 30% of 4-dione in the peripheral circulation (160).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [160]

Source of Estrogen Production in Postmenopausal Women1
GRODIN, J. M., SIITERI, P. K., & MACDONALD, P. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-2-207 · Cited by 959 · see citing works
Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood.
JUDD, H. L., JUDD, G. E., LUCAS, W. E., & YEN, S. S. C. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-6-1020 · Cited by 511 · see citing works
Plasma Precursors of Estrogen. II. Correlation of the Extent of Conversion of Plasma Androstenedione to Estrone with Age<sup>1</sup>
HEMSELL, D. L., GRODIN, J. M., BRENNER, P. F., SIITERI, P. K., & MACDONALD, P. C. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-3-476 · Cited by 444 · see citing works
Aromatization of Androgens by Human Abdominal and Breast Fat Tissue1
NIMROD, A., & RYAN, K. J. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-3-367 · Cited by 314 · see citing works
Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer.
Judd, H. L., Lucas, W. E., & Yen, S. S. C. (1974) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(74)90490-6 · Cited by 261 · see citing works
Concentration of Unconjugated Estrone and Estradiol in Peripheral Plasma in Nonpregnant Women Throughout the Menstrual Cycle, Castrate and Postmenopausal Women and in Men1
Baird, D. T., & Guevara, A. P. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-2-149 · Cited by 176 · see citing works
Measurement of Testosterone and 17-Ketosteroids in Plasma by the Double Isotope Dilution Derivative Technique1
GANDY, H. M., & Peterson, R. E. (1968) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-28-7-949 · Cited by 168 · see citing works
Serum Steroid Levels During the Menstrual Cycle in a Bilaterally Adrenalectomized Woman
Abraham, G. E., & Chakmakjian, Z. H. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-4-581 · Cited by 134 · see citing works
Radioimmunoassay of 17β-hydroxy-5α-androstan-3-one, 4-androstene-3,17-dione, dehydroepiandrosterone, 17-hydroxyprogesterone and progesterone and its application to human male plasma
Vermeulen, A., & Verdonck, L. (1976) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(76)90156-4 · Cited by 134 · see citing works
Self-citation
Radioimmunoassay of Plasma Pregnenolone, 17-Hydroxypregnenolone and Dehydroepiandrosterone Under Various Physiological Conditions
Abraham, G. E., Buster, J. E., KYLE, F. W., Corrales, P. C., & Teller, R. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-1-140 · Cited by 81 · see citing works
Simultaneous radio immunoassay of testosterone and dihydrotestosterone
Barberia, J. M., & Thorneycroft, I. H. (1974) · Steroids · doi:10.1016/0039-128x(74)90163-9 · Cited by 58 · see citing works
The Evaluation of the Role of Androgens in Hirsutism and the Use of a New Anti-androgen “Cyproterone Acetate” for Therapy
Ismail, A. A., DAVIDSON, D. W., Souka, A. R., Barnes, E. W., Irvine, W. J., KILIMNIK, H., & Vanderbeeken, Y. E. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-1-81 · Cited by 58 · see citing works
Plasma Testosterone in the Normal Woman
Lobotsky, J., WYSS, H. I., Segre, E. J., & Lloyd, C. W. (1964) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-24-12-1261 · Cited by 58 · see citing works
Estradiol Production after Ovariectomy for Carcinoma of the Breast
Barlow, J. J., Emerson, K., & Saxena, B. N. (1969) · New England Journal of Medicine · doi:10.1056/nejm196903202801203 · Cited by 57 · see citing works
Metabolism of testosterone and androstenedione in normal and ovariectomized women
Abraham, G. E., Lobotsky, J., & Lloyd, C. W. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106027 · Cited by 53 · see citing works
ADRENAL AND TESTICULAR CONTRIBUTION TO PLASMA OESTROGENS
Saez, J. M., MORERA, A. M., Dazord, A., & Bertrand, J. (1972) · Journal of Endocrinology · doi:10.1677/joe.0.0550041 · Cited by 42 · see citing works
Comparison of quick methods for the estimation of estradiol in plasma by radioimmunoassay
Verdonck, L., & Vermeulen, A. (1974) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(74)90046-6 · Cited by 36 · see citing works
Self-citation
CIRCADIAN VARIATIONS IN PLASMA PROGESTERONE IN THE LUTEAL PHASE OF THE MENSTRUAL CYCLE AND DURING PREGNANCY
Runnebaum, B., Rieben, W. K., Münstermann, A.-M. B.-V., & Zander, J. (1972) · European Journal of Endocrinology · doi:10.1530/acta.0.0690731 · Cited by 25 · see citing works
Variations in the concentrations of androstenedione in peripheral plasma of women during the day and during the menstrual cycle)
Lobotsky, J., & Lloyd, C. W. (1973) · Steroids · doi:10.1016/0039-128x(73)90078-0 · Cited by 9 · see citing works
PRECURSORS OF THE URINARY ll-DESOXY-17-KETOSTEROIDS OF OVARIAN ORIGIN
MacDonald, P. C., Wiele, R. L. V., & Lieberman, S. (1963) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-196310000-00032 · Cited by 2 · see citing works

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Laughlin, G. A., Barrett-Connor, E. L., Kritz‐Silverstein, D. C., & von Mühlen, D. G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6405 · Cited by 381 · see citing works
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Judd, H. L., Davidson, B. J., Frumar, A. M., Shamonki, I. M., Lagasse, L. D., & Ballon, S. C. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)91043-1 · Cited by 114 · see citing works
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Longcope, C., Hunter, R., & Franz, C. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90287-2 · Cited by 103 · see citing works
Postmenopausal estrogen synthesis and metabolism: Alterations caused by aromatase inhibitors used for the treatment of breast cancer
Lønning, P. E., Dowsett, M., & Powles, T. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90241-j · Cited by 103 · see citing works
Mechanisms of Action of Aminoglutethimide as Endocrine Therapy of Breast Cancer
Lønning, P. E., & Kvinnsland, S. (1988) · Drugs · doi:10.2165/00003495-198835060-00005 · Cited by 102 · see citing works
The relationship between body mass and breast cancer among women enrolled in the cancer and steroid hormone study
Chu, S. Y., Lee, N. C., Wingo, P. A., Senie, R. T., Greenberg, R. S., & Peterson, H. B. (1991) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(91)90152-y · Cited by 98 · see citing works
Effect of prolactin on plasma DHEA(S) levels
Vermeulen, A., Suy, E., & Rubens, R. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-44-6-1222 · Cited by 97 · see citing works
Self-citation
Effects of age on messenger RNA expression of glucocorticoid, thyroid hormone, androgen, and estrogen receptors in postmortem human hippocampus
Tohgi, H., Utsugisawa, K., Yamagata, M., & Yoshimura, M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00971-r · Cited by 96 · see citing works
Location and concentration of estrogen, progesterone, and androgen receptors in the bladder and urethra of the rabbit
ROSENZWEIG, B. A., Bolina, P. S., Birch, L. A., Moran, C., Marcovici, I., & Prins, G. S. (1995) · Neurourology and Urodynamics · doi:10.1002/nau.1930140114 · Cited by 96 · see citing works
A prospective long-term study in women from pre-menopause to post-menopause: changing profiles of gonadotrophins, oestrogens and androgens
Rannevik, G., Carlström, K., Jeppsson, S., Bjerre, B., & Svanberg, L. (1986) · Maturitas · doi:10.1016/0378-5122(86)90038-1 · Cited by 95 · see citing works
Hysterectomy, Oophorectomy, and Endogenous Sex Hormone Levels in Older Women: The Rancho Bernardo Study
Laughlin, G. A., Barrett-Connor, E. L., Kritz‐Silverstein, D. C., & von Mühlen, D. G. (2000) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200007000-00020 · Cited by 94 · see citing works
The effects of a low-fat dietary intervention and tamoxifen adjuvant therapy on the serum estrogen and sex hormone-binding globulin concentrations of postmenopausal breast cancer patients
Rose, D. P., Connolly, J. M., Chlebowski, R. T., Buzzard, I. M., & Wynder, E. L. (1993) · Breast Cancer Research and Treatment · doi:10.1007/bf00665695 · Cited by 93 · see citing works
Hypoactive sexual desire disorder in postmenopausal women
Nappi, R. E., Wawra, K., & Schmitt, S. (2006) · Gynecological Endocrinology · doi:10.1080/09513590600762265 · Cited by 92 · see citing works
Ovarian Conservation at the Time of Hysterectomy for Benign Disease
Parker, W. H., Broder, M. S., Liu, Z., Shoupe, D., Farquhar, C. M., & Berek, J. S. (2007) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e31804a838d · Cited by 91 · see citing works
Hormonal Status in Normal, Osteoporotic and Corticosteroid-Treated Postmenopausal Women
Crilly, R., Cawood, M., Marshall, D. H., & Nordin, B. E. C. (1978) · Journal of the Royal Society of Medicine · doi:10.1177/014107687807101006 · Cited by 90 · see citing works
A comparative analysis of the role of androgen in human male and female sexual behavior: Behavioral specificity, critical thresholds, and sensitivity
Sherwin, B. B. (1988) · Psychobiology · doi:10.3758/bf03327339 · Cited by 86 · see citing works
An immunohistochemical evaluation of androgen and progesterone receptors in ovarian tumors
Chadha, S., Rao, B. R., Slotman, B. J., van Vroonhoven, C. C. J., & van der Kwast, T. (1993) · Human Pathology · doi:10.1016/0046-8177(93)90067-q · Cited by 84 · see citing works
Prospective Study of Relative Weight and Risk of Breast Cancer: The Breast Cancer Detection Demonstration Project Follow-up Study, 1979 to 1987-1989
Yong, L.-C., Brown, C. C., Schatzkin, A. G., & Schairer, C. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008681 · Cited by 84 · see citing works
Peripheral aromatization as a risk factor for breast and endometrial cancer in postmenopausal women: A review
Enriori, C. L., & Reforzo-Membrives, J. (1984) · Gynecologic Oncology · doi:10.1016/0090-8258(84)90055-6 · Cited by 83 · see citing works
Endocrine effects and pharmacokinetic characteristics of a potent new gonadotropin-releasing hormone antagonist (Ganirelix) with minimal histamine-releasing properties: studies in postmenopausal women
Rabinovici, J., Rothman, P. A., Monroe, S. E., Nerenberg, C., & Jaffe, R. B. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.5.1385467 · Cited by 83 · see citing works
Endometrium and plasma hormone profile in the peri-menopause and post-menopause
Trévoux, R., de Brux, J., Castanier, M., NAHOUL, K., Soule, J.-P., & Scholler, R. (1986) · Maturitas · doi:10.1016/0378-5122(86)90039-3 · Cited by 80 · see citing works
The influence of CGS 16949A on peripheral aromatisation in breast cancer patients
Lønning, P. E., Jacobs, S., Jones, A. L., Haynes, B. P., Powles, T., & Dowsett, M. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.175 · Cited by 80 · see citing works
Stromal Cells of the Human Postmenopausal Ovary Display a Distinctive Biochemical and Molecular Phenotype
Jabara, S. I., Christenson, L. K., Wang, C. Y., McAllister, J. M., Javitt, N. B., Dunaif, A. E., & Strauss, J. F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021274 · Cited by 79 · see citing works
Endocrine effects of low dose aminoglutethimide alone in advanced postmenopausal breast cancer
Harris, A. L., Dowsett, M., Smith, I. E., & Jeffcoate, S. L. (1983) · British Journal of Cancer · doi:10.1038/bjc.1983.100 · Cited by 79 · see citing works
Lifelong Estrogen Exposure and Cognitive Performance in Elderly Women
Smith, C. A., McCleary, C. A., Murdock, G. A., Wilshire, T. W., Buckwalter, D. K., Bretsky, P., MARMOL, L. M., Gorsuch, R. L., & Buckwalter, J. G. (1999) · Brain and Cognition · doi:10.1006/brcg.1999.1078 · Cited by 78 · see citing works
The effects of body mass index on age at menopause
Akahoshi, M., Soda, M., Nakashima, E., Tominaga, T., Ichimaru, S., Seto, S., & Yano, K. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802039 · Cited by 77 · see citing works
Mortality in a cohort of women given X‐ray therapy for metropathia haemorrhagica
Darby, S. C., Reeves, G., Key, T. J., Doll, R., & Stovall, M. A. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560606 · Cited by 76 · see citing works
Reproductive hormone levels in gynecologic oncology patients undergoing surgical castration after spontaneous menopause
Hughes, C. L., Wall, L. L., & Creasman, W. T. (1991) · Gynecologic Oncology · doi:10.1016/0090-8258(91)90083-h · Cited by 76 · see citing works
Testosterone, SHBG and cardiovascular health in postmenopausal women
Brand, J. S., & van der Schouw, Y. T. (2010) · International Journal of Impotence Research · doi:10.1038/ijir.2009.64 · Cited by 73 · see citing works
Elective oophorectomy for benign gynecological disorders
Shoupe, D., Parker, W. H., Broder, M. S., Liu, Z., Farquhar, C. M., & Berek, J. S. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31803c56a4 · Cited by 73 · see citing works
Hirsutism
Rittmaster, R. S., & LORIAUX, D. L. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-1-95 · Cited by 73 · see citing works
Novel compounds inhibit estrogen formation and action.
Labrie, C., Martel, C., Dufour, J. M., Lévesque, C., Mérand, Y., & Labrie, F. (1992) · PubMed · Cited by 73 · see citing works
Sex hormones and psychological functioning in postmenopausal women
Sherwin, B. B. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90021-3 · Cited by 72 · see citing works
Androgen insufficiency in women: summary of critical issues
Braunstein, G. D. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02962-x · Cited by 71 · see citing works
HORMONAL PROFILES IN POSTMENOPAUSAL WOMEN AFTER THERAPY WITH SUBCUTANEOUS IMPLANTS
Thom, M. H., Collins, W. P., & Studd, J. W. W. (1981) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1981.tb01008.x · Cited by 71 · see citing works
PLASMA LEVELS OF OESTRONE, OESTRADIOL AND GONADOTROPHINS IN POSTMENOPAUSAL WOMEN AFTER ORAL AND VAGINAL ADMINISTRATION OF CONJUGATED EQUINE OESTROGENS (PREMARIN)
Englund, D. E., & Johansson, E. D. B. (1978) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1978.tb15860.x · Cited by 71 · see citing works
Dehydroepiandrosterone: Is There a Role for Replacement?
Dhatariya, K., & Nair, K. S. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.10.1257 · Cited by 71 · see citing works
Androgen and estrogen-androgen hormone replacement therapy: a review of the safety literature, 1941 to 1996
Gelfand, M. M., & Wiita, B. (1997) · Clinical Therapeutics · doi:10.1016/s0149-2918(97)80125-7 · Cited by 68 · see citing works
Clinical Pharmacokinetics of Endocrine Agents Used in Advanced Breast Cancer
Lønning, P. E., Lien, E. A., Lundgren, S., & Kvinnsland, S. (1992) · Clinical Pharmacokinetics · doi:10.2165/00003088-199222050-00002 · Cited by 68 · see citing works

Effect of exogenous estrogen on serum pregnenolone, cortisol, and androgens in postmenopausal women.
Abraham, G. E., & Maroulis, G. B. (1975) · PubMed · Cited by 86 · see citing works
Ovarian and adrenal contributions to peripheral steroid levels in postmenopausal women.
Gb, M., & Ge, A. (1976) · PubMed · Cited by 53 · see citing works
The Postmenopausal Ovary Is Not a Major Androgen-Producing Gland
Couzinet, B., Méduri, G., Lecce, M. G., Young, J., Brailly, S., Loosfelt, H., Milgröm, E., & SCHAISON, G. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7900 · Cited by 210 · see citing works
Ovarian and adrenal steroid production in the postmenopausal woman.
Rb, G., Ml, C., & Vb, M. (1976) · PubMed · Cited by 123 · see citing works
Ovarian and adrenal steroid production: regulatory role of LH/HCG
Piltonen, T., Koivunen, R., Morin-Papunen, L. C., Ruokonen, A., Huhtaniemi, I. T., & Tapanainen, J. S. (2002) · Human Reproduction · doi:10.1093/humrep/17.3.620 · Cited by 70 · see citing works

Authors: VERMEULEN, A.
Affiliations: Ghent University (BE)
Corresponding author: VERMEULEN, A.
ORCID: VERMEULEN, A.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1976-02
Volume: 42
Issue: 2
Pages: 247-253
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-42-2-247
OpenAlex: W1992502576
Cited by: 379
References: 20
Citations by year: 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 5
FWCI: 13.61
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: postmenopausal ovary, ovarian steroid secretion, plasma sex hormones, estradiol, estrone, progesterone, 17-hydroxyprogesterone, testosterone, androstenedione, dehydroepiandrosterone, adrenal cortex, ACTH stimulation test, dexamethasone suppression, hCG stimulation, ovariectomy
MeSH terms: Adrenal Glands, Adrenocorticotropic Hormone, Aged, Androstenedione, Castration, Circadian Rhythm, Dehydroepiandrosterone, Dexamethasone, Estradiol, Estrone, Female, Chorionic Gonadotropin, Humans, Hydroxyprogesterones, Menopause, Middle Aged, Ovary, Progesterone, Gonadal Steroid Hormones, Dihydrotestosterone, Testosterone

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The hormonal activity of the postmenopausal ovary.

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