Permeability of placenta to inulin
Abstract
Inulin was administered to eight volunteer patients at term gestation over a period of 3 hours before cesarean section. Inulin concentrations were repeatedly measured in maternal plasma, in fetal plasma, and in amniotic fluid at the time of delivery. Total inulin uptake of the conceptus was taken to be the sum of the inulin in the amniotic fluid and in the newborn infant. Amniotic fluid volumes were measured by ultrasound examination, and the distribution volume of inulin in the neonate was assumed to be 180 ml/kg on the basis of animal experiments. The mean permeability was 0.15 microliter/(s.g) placenta. This value and the previously measured permeability for cyanocobalamin delimit a range of molecular weights from 1350 to 5200 daltons. In this range permeability to lipid-insoluble molecules is roughly proportional to the coefficients of free diffusion in water without further discrimination of molecular size by the placental barrier.
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The human placenta is permeable to solutes of up to 5,200 daltons.
“The presence of such pores is evidenced by data showing that the human placenta is permeable to solutes of up to 5,200 daltons (529, 575).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [529]
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Self-citationDiffusion permeability of cyanocobalamin in human placenta
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Self-citationTRANSFER OF RADIOACTIVE SODIUM ACROSS THE PLACENTA OF THE GUINEA PIG
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
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- Authors
- Thornburg, K. L., Burry, K. J., Adams, A. K., Paul Kirk, E., & Faber, J. J.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Faber, J. Job
- ORCID
- Thornburg, Kent L.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1988-05
- Volume
- 158
- Issue
- 5
- Pages
- 1165-1169
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2003367324
- Cited by
- 39
- References
- 14
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2017: 1 · 2016: 2 · 2015: 1
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd016342-05)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1R01 HD16342)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- placental permeability, inulin, placental barrier, amniotic fluid, molecular weight, free diffusion, term pregnancy, cesarean section
- MeSH terms
- Amniotic Fluid, Birth Weight, Female, Fetal Blood, Humans, Inulin, Maternal-Fetal Exchange, Molecular Weight, Organ Size, Permeability, Placenta, Pregnancy, Solubility
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