Diffusion permeability of cyanocobalamin in human placenta
Abstract
The molecular weight of cyanocobalamin is well suited to distinguish the two patterns of size discrimination found in the hemochorial and epitheliochorial placentas. The concentrations of cyanocobalamin that were used ensured that nondiffusional transport was negligible, and experiments on guinea pigs confirmed that the diffusion permeabilities measured with cyanocobalamin were the same as those expected for inert hydrophilic substances of similar molecular weight. All human studies were performed on volunteers who were scheduled for elective cesarean section under spinal or epidural anesthesia. Endogenous plasma concentrations of cobalamin were measured in 10 pregnant volunteers and their newborns. Ten additional volunteers were given 1 mg of cyanocobalamin by intramuscular injection 44 min before delivery. Placental permeability, calculated as the ratio of fetal uptake and the concentration-time integral between maternal and fetal plasmas, was 14.3 microliter X min-1 X g placental wt-1. The permeability of the human placenta parallels that of the histologically similar guinea pig placenta, at a slightly higher level, up to molecular weights of 1,355.
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The human placenta is permeable to solutes of up to 5,200 daltons.
“The presence of such pores is evidenced by data showing that the human placenta is permeable to solutes of up to 5,200 daltons (529, 575).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [575]
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- Authors
- Willis, D. M., O'Grady, J. P., Faber, J. J., & Thornburg, K. L.
- ORCID
- Thornburg, K. L.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1986-03-01
- Volume
- 250
- Issue
- 3
- Pages
- R459-R464
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2199620494
- Cited by
- 46
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-16342)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- vitamin B12, human placenta, hemochorial placenta, epitheliochorial placenta, maternal-fetal transfer, placental transport
- MeSH terms
- Adult, Animals, Blood Proteins, Capillary Permeability, Diffusion, Female, Fetal Blood, Guinea Pigs, Humans, Maternal-Fetal Exchange, Placenta, Pregnancy, Vitamin B 12
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