The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Evaluation of the lemon and banana signs in one hundred thirty fetuses with open spina bifida
Abstract
The incidence and diagnostic accuracy of the lemon and cerebellar ultrasonographic markers, as well as head size and ventriculomegaly, were evaluated in a study of 1561 patients at high risk for fetal neural tube defects. In the 130 fetuses with open spina bifida there was a relationship between gestational age and the presence of each of these markers. The lemon sign was present in 98% of fetuses at less than or equal to 24 weeks' gestation but in only 13% of those at greater than 24 weeks' gestation. Cerebellar abnormalities were present in 95% of fetuses irrespective of gestation; however, the cerebellar abnormality at less than or equal to 24 weeks' gestation was predominantly the banana sign (72%) whereas at gestations greater than 24 weeks it was cerebellar "absence" (81%). Both growth retardation and cerebral ventriculomegaly significantly worsened with gestation while the head circumference remained disproportionately small throughout gestation. On the basis of these data, a new approach is proposed for the investigation of patients at high risk for fetal open spina bifida.
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“The most frequent severe spinal anomaly, open spina bifida, is usually associated with a characteristic cerebellar deformity and an obliterated cisterna magna 83 .”
From ISUOG Practice Guidelines (updated): performance of the routine mid‐trimester fetal ultrasound scan (2022) · cites this paper as [83]
Citations
Cites
RANDOMISED CONTROLLED TRIAL OF GENETIC AMNIOCENTESIS IN 4606 LOW-RISK WOMEN
Tabor, A., Madsen, M. E., Obel, E., Philip, J., Bang, J., & Gaard-Pedersen, B. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91218-3 · Cited by 866
Ueber Veränderungen des Kleinhirns infolge von Hydrocephalie des Grosshirns1)
Chiari, H. (1891) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0029-1206803 · Cited by 553
ULTRASOUND SCREENING FOR SPINA BIFIDA: CRANIAL AND CEREBELLAR SIGNS
Nicolaides, K. H., Gabbe, S. G., Campbell, S. C., & Guidetti, R. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91610-7 · Cited by 400
Self-citationWalton, J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)91007-0 · Cited by 351
Philip, W. P. (1948) · PubMed · Cited by 172
Spina Bifida and Cranium Bifidum
Ingraham, F. D., & Scott, H. W. (1943) · New England Journal of Medicine · doi:10.1056/nejm194307152290302 · Cited by 145
Ultrasound screening for spina bifida: cranial and cerebellar signs in a high-risk population.
Campbell, J. B., Gilbert, W. M., Nicolaides, K. H., & Campbell, S. C. (1987) · PubMed · Cited by 93
Self-citationSMALL BIPARIETAL DIAMETER OF FETUSES WITH SPINA BIFIDA: IMPLICATIONS FOR ANTENATAL SCREENING
Wald, N. J., Cuckle, H. S., Boreham, J., & Stirrat, G. M. (1980) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1980.tb04522.x · Cited by 74
Williams, B. (1975) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1975.tb03594.x · Cited by 66
Nyberg, D. A., Mack, L. A., Hirsch, J. H., & MAHONY, B. S. (1988) · Radiology · doi:10.1148/radiology.167.2.3282259 · Cited by 60
Research works printed but not linked: 1
- Schwalbe, 1907, Uber Entwicklungsstorungen des Kleinhirns, Hirnstamms and Halsmarks bei Spina Bifida, Beitr Patol Anat, 40, 132
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Copp, A. J., Adzick, N. S., Chitty, L. S., Fletcher, J. M., Holmbeck, G. N., & Shaw, G. M. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.7 · Cited by 671
ISUOG Practice Guidelines (updated): performance of the routine mid‐trimester fetal ultrasound scan
Salomon, L. J., Alfirevic, Z., Berghella, V., Bilardo, C. M., Chalouhi, G. E., Da Silva Costa, F., Hernandez‐Andrade, E., Malinger, G., Munoz, H., Paladini, D., et al. (2022) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.24888 · Cited by 436
Assessment of intracranial translucency (IT) in the detection of spina bifida at the 11–13-week scan
Chaoui, R., Benoit, B., Mitkowska‐Wozniak, H., Heling, K. S., & Nicolaides, K. H. (2009) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.7329 · Cited by 321
Self-citationThe effects of methotrexate on pregnancy, fertility and lactation
Lloyd, M. E. (1999) · QJM · doi:10.1093/qjmed/92.10.551 · Cited by 248
Chiari Type II malformation: past, present, and future
Stevenson, K. L. (2004) · Neurosurgical FOCUS · doi:10.3171/foc.2004.16.2.6 · Cited by 207
Metadata
- Authors
- Van den Hof, M. C., Nicolaides, K. H., Campbell, J., & Campbell, S.
- Affiliations
- King's College London (GB)
- Corresponding author
- Nicolaides, Kypros H.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1990-02
- Volume
- 162
- Issue
- 2
- Pages
- 322-327
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2107615644
- Cited by
- 207
- References
- 16
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 3 · 2015: 8 · 2014: 9 · 2013: 12 · 2012: 10
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Dysraphism and Malformations
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Keywords
- open spina bifida, fetal neural tube defects, ventriculomegaly, fetal growth restriction, head circumference, gestational age, prenatal diagnosis, diagnostic accuracy
- MeSH terms
- Arnold-Chiari Malformation, Brain, Cerebellum, Female, Fetal Diseases, Humans, Pregnancy, Prenatal Diagnosis, Skull, Ultrasonography, Spina Bifida Occulta
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