Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells
Abstract
Preeclampsia occurs in 7% to 10% of pregnancies and is a leading cause of morbidity for mothers and their infants. Intensive investigation has failed to reveal the cause of the multiple organ dysfunction characteristic of this disorder, which abates completely with delivery. However, several observations suggest that endothelial cell dysfunction is a central pathophysiologic event. We report that serum from preeclamptic women is cytotoxic to endothelial cells in vitro. Consistent with the reversal of the clinical condition after delivery, cytotoxic activity in serum of preeclamptic women is reduced after 24 to 48 hours post partum. In contrast, cytotoxic activity of serum from normal pregnant women increases after delivery.
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Gui et al. suggested that metformin reduced the rate of gestational hypertension because of its effects on endothelial function and its decrease in the production of reactive oxygen species.
“Gui et al.(75) suggested that metformin reduced the rate of gestational hypertension because of its effects on endothelial function and its decrease in the production of reactive oxygen species, the two mechanisms implicated in the pathophysiology of preeclampsia(84–94).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [84]
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- Authors
- Rodgers, G. M., Taylor, R. N., & Roberts, J. M.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Roberts, James M.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1988-10
- Volume
- 159
- Issue
- 4
- Pages
- 908-914
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2091580324
- Cited by
- 278
- References
- 27
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 20.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08hl001031-04)
- National Heart, Lung, and Blood Institute (HL 33005, 1 K08HL 01031)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- preeclampsia, endothelial cell cytotoxicity, serum factors, endothelial dysfunction, postpartum recovery, multiple organ failure, pregnancy
- MeSH terms
- Antibodies, Chromium Radioisotopes, Endothelium, Vascular, Female, Humans, Labor, Obstetric, Magnesium Sulfate, Pre-Eclampsia, Pregnancy, Time Factors, Umbilical Veins, In Vitro Techniques
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