Virilizing adrenal carcinoma in a woman of reproductive age: a case presentation and literature review
Abstract
Virilizing adrenal carcinoma is a rare disease, especially in women of reproductive age. A young woman who was seen with hirsutism, virilization, and infertility had a well-differentiated adrenal cortical carcinoma. After treatment she conceived twice and currently is disease free 8 years after treatment. This case illustrates that adrenal carcinoma and its treatment need not eliminate a woman's reproductive potential.
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At least 6 pregnancies with conception during or shortly after mitotane therapy have been reported; four children were born evidently healthy, and no birth defects were encountered.
“At least 6 pregnancies with conception during or shortly after mitotane therapy have been reported. Four children were born evidently healthy, and no birth defects were encountered (305–307).”
From Adrenocortical carcinoma (2014) · cites this paper as [306]
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Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
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- Authors
- Coonrod, D. V., & Rizkallah, T. H.
- Affiliations
- Maricopa Medical Center (US)
- Corresponding author
- Rizkallah, Tawfik H.
- ORCID
- Coonrod, Dean V.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 172
- Issue
- 6
- Pages
- 1912-1915
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2075307959
- Cited by
- 15
- References
- 17
- Citations by year
- 2023: 2 · 2017: 1 · 2016: 1 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- adrenocortical carcinoma, hirsutism, masculinization, infertility, women of reproductive age, fertility preservation, pregnancy after cancer treatment
- MeSH terms
- Adrenal Cortex Neoplasms, Adrenalectomy, Adult, Carcinoma, Female, Hirsutism, Humans, Infertility, Female, Mitotane, Prednisone, Pregnancy, Virilism
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