Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases

Tissue sulfhydryl groups

Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824 · see citing works

The preparation and properties of two new chromogenic substrates of trypsin

Erlanger, B. F., Kokowsky, N., & Cohen, W. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90145-x · Cited by 3,379 · see citing works

Determination of sulfhydryl groups with 2,2′- or 4,4′-dithiodipyridine

Grassetti, D. R., & Murray, J. F. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90426-2 · Cited by 994 · see citing works

The synthesis and analytical use of a highly sensitive and convenient substrate of elastase

Bieth, J. G., Spiess, B., & Wermuth, C. G. (1974) · Biochemical Medicine · doi:10.1016/0006-2944(74)90134-3 · Cited by 732 · see citing works

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

Nakajima, K., Powers, J. C., Ashe, B. M., & Zimmerman, M. D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50690-6 · Cited by 595 · see citing works

New Fluorogenic Substrates for α-Thrombin, Factor Xa, Kallikreins, and Urokinase1

Morita, T., Kato, H., Iwanaga, S., Takada, K., Kimura, T., & Sakakibara, S. (1977) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131840 · Cited by 382 · see citing works

Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substrates

Zimmerman, M. D., Ashe, B. M., Yurewicz, E. C., & Patel, G. F. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90006-9 · Cited by 264 · see citing works

Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

Powers, J. C., Gupton, B. F., Harley, A. D., Nishino, N., & Whitley, R. J. (1977) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(77)90203-0 · Cited by 223 · see citing works

A new fluorogenic substrate for chymotrypsin

Zimmerman, M., Yurewicz, E. C., & Patel, G. F. (1976) · Analytical Biochemistry · doi:10.1016/s0003-2697(76)80066-8 · Cited by 187 · see citing works

On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1

McDonald, J. K., & Ellis, S. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90137-x · Cited by 165 · see citing works

Proteases from purulent sputum. Purification and properties of the elastase and chymotrypsin-like enzymes.

Twumasi, D. Y., & Liener, I. E. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71845-0 · Cited by 115 · see citing works

Substrate specificity of the elastase and the chymotrypsin-like enzyme of the human granulocyte

Zimmerman, M., & Ashe, B. M. (1977) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(77)90337-0 · Cited by 99 · see citing works

Fluorescence assay of X-prolyl dipeptidyl-aminopeptidase activity with a new fluorogenic substrate

Kato, T., Nagatsu, T., Kimura, T., & Sakakibara, S. (1978) · Biochemical Medicine · doi:10.1016/0006-2944(78)90035-2 · Cited by 93 · see citing works

Active-site specific inhibitors of elastase

Powers, J. C., & Tuhy, P. M. (1973) · Biochemistry · doi:10.1021/bi00747a032 · Cited by 87 · see citing works

The action of elastase on p-nitroanilide substrates

Bieth, J. G., & Wermuth, C. G. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)90673-6 · Cited by 81 · see citing works

Synthesis of a key fluorogenic amide, L-arginine-4-methylcoumaryl-7-amide (L-Arg-MCA) and its derivatives. Fluorescence assays for trypsin and papain.

Kanaoka, Y., TAKAHASHI, T., Nakayama, H., Takada, K., Kimura, T., & Sakakibara, S. (1977) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.25.3126 · Cited by 65 · see citing works

N-acetyl-(L-Ala)3-p-nitroanilide as a new chromogenic substrate for elastase

Feinstein, G., Kupfer, A., & Sokolovsky, M. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)91508-8 · Cited by 62 · see citing works

A new fluorogenic substrate for aminopeptidase.

Kanaoka, Y., TAKAHASHI, T., & Nakayama, H. (1977) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.25.362 · Cited by 57 · see citing works

Mechanisms of pulmonary injury

Turino, G. M., Rodriguez, J. R., Greenbaum, L. M., & Mandl, I. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90142-9 · Cited by 55 · see citing works

Peptide chloromethyl ketones as irreversible inhibitors of elastase

Thompson, R. C., & BLOUT, E. R. (1973) · Biochemistry · doi:10.1021/bi00725a008 · Cited by 54 · see citing works

Fluorescent substrate assay for antithrombin III

Mitchell, G. A., Hudson, P. M., Huseby, R. M., Pochron, S. P., & Gargiulo, R. J. (1978) · Thrombosis Research · doi:10.1016/0049-3848(78)90293-1 · Cited by 48 · see citing works

Inhibition of human leukocyte elastase by peptide chloromethyl ketones

Tuhy, P. M. (1975) · FEBS Letters · doi:10.1016/0014-5793(75)80527-8 · Cited by 47 · see citing works

Use of N-benzoyl-L-tyrosine thiobenzyl ester as a protease substrate. Hydrolysis by alpha-chymotrypsin and subtilisin BPN.

Farmer, D. A., & Hageman, J. H. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40953-8 · Cited by 40 · see citing works

Use of peptidyl-4-methoxy-2-naphthylamides to assay plasmin

Clavin, S. A., Bobbitt, J. L., Shuman, R. T., & Smithwick, E. L. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90656-x · Cited by 32 · see citing works

Studies on tissue culture plasminogen activator II. The detection and assay of urokinase and plasminogen activator from LLC-PK1 cultures (porcine) by the synthetic substrate Nα-benzyloxycarbonyl-glycyl-glycyl-arginyl-4-methoxy-2-napthylamide

Huseby, R. M., Clavin, S. A., Smith, R. E., HULL, R. N., & Smithwick, E. L. (1977) · Thrombosis Research · doi:10.1016/0049-3848(77)90050-0 · Cited by 26 · see citing works

The Reaction of Active‐Site Inhibitors with Elastase Using a New Assay Substrate

Thomson, A., & Denniss, I. S. (1973) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1973.tb03024.x · Cited by 18 · see citing works

Sensitive fluorescence assays for urokinase using synthetic peptide 4-methoxy-β-naphthylamide substrates

Bigbee, W. L., Weintraub, H. B., & Jensen, R. H. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90403-7 · Cited by 17 · see citing works

Several Derivatives of Acetyl-dl-phenylalanine1

Goldenberg, V., Goldenberg, H., & McLaren, A. (1950) · Journal of the American Chemical Society · doi:10.1021/ja01167a512 · Cited by 13 · see citing works

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

Korkmaz, B., Horwitz, M. S., Jenne, D. E., & Gauthier, F. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002733 · Cited by 873 · see citing works

Replacement Therapy for Alpha1-Antitrypsin Deficiency Associated with Emphysema

Wewers, M. D., Casolaro, M. A., Sellers, S. E., Swayze, S. C., McPhaul, K. M., Wittes, J. T., & Crystal, R. G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704233161704 · Cited by 631 · see citing works

Matrix Metalloproteinase Expression and Production by Alveolar Macrophages in Emphysema

Finlay, G. A., O’Driscoll, L., RUSSELL, K. J., D'ARCY, E. M., Masterson, J., FitzGerald, M. X., & O'CONNOR, C. M. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.1.9612018 · Cited by 437 · see citing works

Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates

Barrett, A. J. (1980) · Biochemical Journal · doi:10.1042/bj1870909 · Cited by 404 · see citing works

IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection

Wu, Q., Martin, R. J., Rino, J. G., Breed, R., Torres, R. M., & Chu, H. W. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.10.012 · Cited by 301 · see citing works

Inhibition of serine proteases by peptidyl fluoromethyl ketones

Imperiali, B., & Abeles, R. H. (1986) · Biochemistry · doi:10.1021/bi00361a005 · Cited by 248 · see citing works

Proteolysis by Neutrophils

Campbell, E. J., Senior, R. M., McDonald, J. A., Cox, D. L., Greco, J. M., & Landis, J. A. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110681 · Cited by 243 · see citing works

Expression of degradative enzymes and protease inhibitors in corneas with keratoconus.

Zhou, L., Sawaguchi, S., Twining, S. S., Sugár, J., Feder, R. S., & Yue, B. Y. (1998) · PubMed · Cited by 220 · see citing works

Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.

Ogushi, F., Fells, G. A., Hubbard, R. C., Straus, S. D., & Crystal, R. G. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113214 · Cited by 215 · see citing works

Human plasma kallikrein releases neutrophil elastase during blood coagulation.

Wachtfogel, Y. T., Kucich, U., James, H. L., Scott, C. F., Schapira, M., Zimmerman, M. D., Cohen, A. B., & Colman, R. W. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111126 · Cited by 211 · see citing works

The major neutral proteinase of Entamoeba histolytica.

Keene, W. E., Petitt, M., Allen, S., & McKerrow, J. H. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.3.536 · Cited by 196 · see citing works

Neutrophil-mediated epithelial injury during transmigration: role of elastase

Ginzberg, H. H., Cherapanov, V., Dong, Q., Cantin, A. M., McCulloch, C. A., Shannon, P. T., & Downey, G. P. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g705 · Cited by 194 · see citing works

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

Kasperkiewicz, P., Poreba, M., Snipas, S. J., Parker, H., Winterbourn, C. C., Salvesen, G. S., & Drag, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318548111 · Cited by 189 · see citing works

Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors

Powers, J. C., Tanaka, T., Harper, J. W., Minematsu, Y., Barker, L. N., Lincoln, D., Crumley, K. V., Fräki, J. E., & Schechter, N. M. (1985) · Biochemistry · doi:10.1021/bi00329a037 · Cited by 175 · see citing works

Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide.

Connelly, J. C., Skidgel, R. A., Schulz, W., Johnson, A. R., & Erdös, E. G. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8737 · Cited by 172 · see citing works

Rhodamine-based compounds as fluorogenic substrates for serine proteinases

Leytus, S. P., Melhado, L. L., & Mangel, W. F. (1983) · Biochemical Journal · doi:10.1042/bj2090299 · Cited by 166 · see citing works

Functional Characteristics of Gingival and Periodontal Ligament Fibroblasts

Giannopoulou, C., & Cimasoni, G. (1996) · Journal of Dental Research · doi:10.1177/00220345960750030601 · Cited by 156 · see citing works

Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansoni.

McKerrow, J. H., Pino-Heiss, S., Lindquist, R. N., & Werb, Z. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83680-3 · Cited by 151 · see citing works

Antistasin, a Leech-derived Inhibitor of Factor Xa

Dunwiddie, C. T., Thornberry, N. A., Bull, H. G., Sardana, M. K., Friedman, P. A., Jacobs, J., & Simpson, E. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84761-0 · Cited by 151 · see citing works

Effect of Dexamethasone on Pulmonary Inflammation and Pulmonary Function of Ventilator-dependent Infants with Bronchopulmonary Dysplasia

Yöder, M. C., Chua, R., & Tepper, R. S. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.5_pt_1.1044 · Cited by 137 · see citing works

Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin.

Wewers, M. D., Herzyk, D. J., & Gadek, J. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113724 · Cited by 131 · see citing works

[44] Leukocyte Elastase

Barrett, A. J. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)80046-8 · Cited by 127 · see citing works

Elastase of U-937 Monocytelike Cells

Senior, R. M., Campbell, E. J., Landis, J. A., Cox, F. R., Kuhn, C., & Koren, H. S. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110462 · Cited by 125 · see citing works

The Herpesvirus Proteases as Targets for Antiviral Chemotherapy

Waxman, L., & Darke, P. L. (2000) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020001100101 · Cited by 122 · see citing works

Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis

Watt, A. P. (2004) · Thorax · doi:10.1136/thx.2003.008037 · Cited by 116 · see citing works

Significance of Cathepsin B Accumulation in Synovial Fluid of Rheumatoid Arthritis

Hashimoto, Y., Kakegawa, H., Narita, Y., Hachiya, Y., Hayakawa, T., Kos, J., Türk, V., & Katunuma, N. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4787 · Cited by 114 · see citing works

Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome.

Idell, S., Kucich, U., Fein, A. M., Kueppers, F., James, H. L., Walsh, P. N., Weinbaum, G., Colman, R. W., & Cohen, A. B. (1985) · PubMed · doi:10.1164/arrd.1985.132.5.1098 · Cited by 110 · see citing works

Elastases: Catalytic and Biological Properties

Bieth, J. G. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-487425-1.50012-7 · Cited by 109 · see citing works

Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice

Mentzel, S., Dijkman, H. B., Van Son, J. P., Koene, R. A., & Assmann, K. J. (1996) · Journal of Histochemistry & Cytochemistry · doi:10.1177/44.5.8627002 · Cited by 108 · see citing works

Purification and characterization of major extracellular proteinases from Trichophyton rubrum

Asahi, M., Lindquist, R. N., Fukuyama, K., Apodaca, G., Epstein, W. L., & McKerrow, J. H. (1985) · Biochemical Journal · doi:10.1042/bj2320139 · Cited by 106 · see citing works

A continuous, spectroscopic analysis of the kinetics of elastase secretion by neutrophils. The dependence of secretion upon receptor occupancy.

Sklar, L. A., McNeil, V. M., Jesaitis, A. J., Painter, R. G., & Cochrane, C. G. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83801-2 · Cited by 105 · see citing works

[2] Fluorimetric assays of proteolytic enzymes

Knight, C. G. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)48004-8 · Cited by 104 · see citing works

Human neutrophils contain and bind high molecular weight kininogen.

Gustafson, E. J., Schmaier, A. H., Wachtfogel, Y. T., Kaufman, N., Kucich, U., & Colman, R. W. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114151 · Cited by 104 · see citing works

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis

Dittrich, S. A., Kühbandner, I., Gehrig, S. M., Rickert-Zacharias, V., Twigg, M. S., Wege, S., Taggart, C. C., Herth, F. J. F., Schultz, C., & Mall, M. A. (2018) · European Respiratory Journal · doi:10.1183/13993003.01910-2017 · Cited by 101 · see citing works

Skin-derived antileucoproteases (SKALPs): characterization of two new elastase inhibitors from psoriatic epidermis

Schalkwijk, J., Chang, A., JANSSEN, P., de Jongh, G. J., & MIER, P. D. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb07285.x · Cited by 101 · see citing works

Safety and Efficacy of Recombinant Alpha1-Antitrypsin Therapy in Cystic Fibrosis

Martin, L., Downey, D. G., Bilton, D., Keogan, M. T., Edgar, J., Elborn, J. S., & on behalf of the Recombinant AAT CF Study Team (2005) · Pediatric Pulmonology · doi:10.1002/ppul.20345 · Cited by 100 · see citing works

Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells

Jean, F., Basak, A., Rondeau, N., Benjannet, S., Hendy, G. N., Seidah, N. G., Chrétien, M., & Lazure, C. (1993) · Biochemical Journal · doi:10.1042/bj2920891 · Cited by 96 · see citing works

Neutrophil cell death, activation and bacterial infection in cystic fibrosis

Watt, A. P. (2005) · Thorax · doi:10.1136/thx.2004.038240 · Cited by 95 · see citing works

Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region.

Johnson, D. A., Barrett, A. J., & Mason, R. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66935-2 · Cited by 95 · see citing works

Effects of Neutrophil Elastase Inhibitor on Bleomycin-Induced Pulmonary Fibrosis in Mice

Taooka, Y., Maeda, A., Hiyama, K., Ishioka, S., & Yamakido, M. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.1.9612077 · Cited by 92 · see citing works

Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates

McRae, B. J., Kurachi, K., Heimark, R. L., Fujikawa, K., Davie, E. W., & Powers, J. C. (1981) · Biochemistry · doi:10.1021/bi00528a022 · Cited by 92 · see citing works

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A.alpha., and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates

Harper, J. W., Cook, R. R., Roberts, C. J., McLaughlin, B. H., & Powers, J. C. (1984) · Biochemistry · doi:10.1021/bi00308a023 · Cited by 91 · see citing works

Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin

Scuderi, P., Nez, P. A., Duerr, M. L., Wong, B. J., & Valdez, C. M. (1991) · Cellular Immunology · doi:10.1016/0008-8749(91)90275-g · Cited by 89 · see citing works

Secretion of a proteolytic anticoagulant by Ancylostoma hookworms.

Hotez, P. J., & Cerami, A. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.157.5.1594 · Cited by 89 · see citing works

Elastase, α2‐macroglobulin and alkaline phosphatase in crevicular fluid from implants with and without periimplantitis

Plagnat, D., Giannopoulou, C., Carrel, A., Bernard, J., Mombelli, A., & Belser, U. C. (2002) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.2002.130301.x · Cited by 88 · see citing works

A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates.

Teshima, T., Griffin, J., & Powers, J. C. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34638-6 · Cited by 88 · see citing works

Neutrophil Elastase and its Inhibitors in Human Gingival Crevicular Fluid during Experimental Gingivitis

Giannopoulou, C., Andersen, E., Demeurisse, C., & Cimasoni, G. (1992) · Journal of Dental Research · doi:10.1177/00220345920710020301 · Cited by 88 · see citing works

Human bronchial leucocyte proteinase inhibitor. Rapid isolation and kinetic analysis with human leucocyte proteinases

Smith, C. E., & Johnson, D. A. (1985) · Biochemical Journal · doi:10.1042/bj2250463 · Cited by 87 · see citing works

Pharmacological profile of PKF242‐484 and PKF241‐466, novel dual inhibitors of TNF‐α converting enzyme and matrix metalloproteinases, in models of airway inflammation

Trifilieff, A., Walker, C., Keller, T. H., Kottirsch, G., & Neumann, U. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704616 · Cited by 86 · see citing works

Spatially Resolved Monitoring of Neutrophil Elastase Activity with Ratiometric Fluorescent Reporters

Gehrig, S. M., Mall, M. A., & Schultz, C. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201109226 · Cited by 85 · see citing works

Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase.

Schrijver, G., Schalkwijk, J., Robben, J. C. M., Assmann, K. J. M., & Koene, R. A. P. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1435 · Cited by 85 · see citing works

PATHOPHYSIOLOGICAL INTERPRETATION OF KINETIC CONSTANTS OF PROTEASE INHIBITORS

Bieth, J. G. (1981) · Elsevier eBooks · doi:10.1016/b978-0-08-027379-2.50020-x · Cited by 84 · see citing works

Inhibition of Proteinase 3 by α1-Antitrypsin In Vitro Predicts Very Fast Inhibition In Vivo

Duranton, J., & Bieth, J. G. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0258oc · Cited by 83 · see citing works

L-Pyroglutamyl-L-prolyl-L-valine-p-nitroanilide, a highly specific substrate for granulocyte elastase

Kramps, J. A., Twisk, C. V., & Derlinden, A. C. V. (1983) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365518309168282 · Cited by 83 · see citing works

Disruption of the Mucosal Barrier During Gut Ischemia Allows Entry of Digestive Enzymes Into the Intestinal Wall

Chang, M., Kistler, E. B., & Schmid‐Schönbein, G. W. (2011) · Shock · doi:10.1097/shk.0b013e318240b59b · Cited by 82 · see citing works

Interaction with Secretory Component Stimulates Effector Functions of Human Eosinophils But Not of Neutrophils

Motegi, Y., & Kita, H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.4340 · Cited by 80 · see citing works

Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors

Harper, J. W., & Powers, J. C. (1985) · Biochemistry · doi:10.1021/bi00346a028 · Cited by 80 · see citing works

A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo

Zhang, X., Wu, H., Li, P., Qu, Z., Tan, M., & Han, K. (2016) · Chemical Communications · doi:10.1039/c6cc04373a · Cited by 79 · see citing works

A nephritogenic rat monoclonal antibody to mouse aminopeptidase A. Induction of massive albuminuria after a single intravenous injection.

Assmann, K. J. M., van Son, J. P., Dijkman, H. B. P. M., & Koene, R. A. P. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.3.623 · Cited by 79 · see citing works

Nanocellulose-Based Biosensors: Design, Preparation, and Activity of Peptide-Linked Cotton Cellulose Nanocrystals Having Fluorimetric and Colorimetric Elastase Detection Sensitivity

Edwards, J. V., Prevost, N. T., French, A. D., Concha, M. C., DeLucca, A. J., & Wu, Q. (2013) · Engineering · doi:10.4236/eng.2013.59a003 · Cited by 76 · see citing works

The Histochemical and Cytochemical Localization of Proteases

Sannes, P. L. (1988) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(88)80004-4 · Cited by 76 · see citing works

Hypoxanthine and Oxygen Induced Lung Injury: A Possible Basic Mechanism of Tissue Damage?

Saugstad, O. D., Hallman, M., Abraham, J. L., Epstein, B. L., Cochrane, C. G., & Gluck, L. (1984) · Pediatric Research · doi:10.1203/00006450-198406000-00002 · Cited by 74 · see citing works

Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group

Tchoupé, J. R., Moreau, T., Gauthier, F., & Bieth, J. G. (1991) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(91)90232-o · Cited by 71 · see citing works

Comparison of alpha-1-antitrypsin levels and antineutrophil elastase capacity of blood and lung in a patient with the alpha-1-antitrypsin phenotype null-null before and during alpha-1-antitrypsin augmentation therapy.

Wewers, M. D., Casolaro, M. A., & Crystal, R. G. (1987) · PubMed · doi:10.1164/arrd.1987.135.3.539 · Cited by 70 · see citing works

Excessive Neutrophil Elastase in Bronchoalveolar Lavage Fluid in Subclinical Emphysema

Yoshioka, A., Betsuyaku, T., Nishimura, M., Miyamoto, K., Kondo, T., & Kawakami, Y. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.6.8520785 · Cited by 69 · see citing works

Sensor materials for the detection of human neutrophil elastase and cathepsin G activity in wound fluid

Hasmann, A., Geweßler, U., Hulla, E., Schneider, K. P., Binder, B., Francesko, A., Tzanov, T., SCHINTLER, M. V., van der Palen, J. A. M., Guebitz, G. M., et al. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01256.x · Cited by 68 · see citing works

Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates.

Kam, C. M., McRae, B. J., Harper, J. W., Niemann, M. A., Volanakis, J. E., & Powers, J. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61371-7 · Cited by 68 · see citing works

Thrombin Enhances Lung Fibroblast Proliferation in Bleomycin-induced Pulmonary Fibrosis

Tani, K., Yasuoka, S., Ogushi, F., Asada, K., Fujisawa, K., Ozaki, T., Sano, N., & Ogura, T. (1991) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/5.1.34 · Cited by 66 · see citing works

The interrelationship between markers of inflammation and oxidative stress in chronic obstructive pulmonary disease: modulation by inhaled steroids and antioxidant

Sadowska, A. M., van Overveld, F. J., Górecka, D., Zdral, A., Filewska, M., Demkow, U. A., Luyten, C., Saenen, E., Zielinski, J., & Backer, W. A. D. (2004) · Respiratory Medicine · doi:10.1016/j.rmed.2004.07.005 · Cited by 64 · see citing works

Lysosomal elastase and cathepsin G in beige mice. Neutrophils of beige (Chediak-Higashi) mice selectively lack lysosomal elastase and cathepsin G.

Takeuchi, K., Wood, H., & Swank, R. T. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.3.665 · Cited by 64 · see citing works

[32] Proteolysis of insoluble elastin

Stone, P. J., Franzblau, C., & Kagan, H. M. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)82089-2 · Cited by 62 · see citing works

Aptamer Capturing of Enzymes on Magnetic Beads to Enhance Assay Specificity and Sensitivity

Zhao, Q., Li, X., & Le, X. C. (2011) · Analytical Chemistry · doi:10.1021/ac203063z · Cited by 62 · see citing works

Kinetics of the conformational alterations associated with nucleophilic modification of .alpha.2-macrobglobulin

Strickland, D. K., Bhattacharya, P., & Olson, S. T. (1984) · Biochemistry · doi:10.1021/bi00309a002 · Cited by 61 · see citing works

Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock

Hu, J., den Steen, P. E. V., Dillen, C., & Opdenakker, G. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.047 · Cited by 55 · see citing works

Human Amyloid P Component: An Elastase Inhibitor

Li, J. J., & Mcadam, K. P. W. J. (1984) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1984.tb00995.x · Cited by 55 · see citing works

Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates

Cho, K., Tanaka, T., Cook, R. R., Kisiel, W., Fujikawa, K., Kurachi, K., & Powers, J. C. (1984) · Biochemistry · doi:10.1021/bi00299a009 · Cited by 55 · see citing works

Neutrophils Mediate Acute Lung Injury in Rabbits: Role of Neutrophil Elastase

Kinoshita, M., Ono, S., & Mochizuki, H. (2000) · European Surgical Research · doi:10.1159/000052215 · Cited by 54 · see citing works

Elastase secreted by activated polymorphonuclear leucocytes causes chondrocyte damage and matrix degradation in intact articular cartilage: escape from inactivation by alpha-1-proteinase inhibitor.

Schalkwijk, J., van den Berg, W. B., van de Putte, L. B., & Joosten, L. A. B. (1987) · PubMed Central · Cited by 54 · see citing works

Frontline Science: Aggregated neutrophil extracellular traps prevent inflammation on the neutrophil-rich ocular surface

Mahajan, A., Grüneboom, A., Hasíková, L., Podolska, M. J., Kling, L., Maueröder, C., Dahms, F., Christiansen, S. H., Lochnit, G., Krenn, V., et al. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.hi0718-249rr · Cited by 53 · see citing works

The predominant protein of canine seminal plasma is an enzyme.

Isaacs, W. B., & Coffey, D. S. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90893-8 · Cited by 52 · see citing works

The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation

Downey, D. G., Brockbank, S., Martin, L., Ennis, M., & Elborn, J. S. (2007) · Pediatric Pulmonology · doi:10.1002/ppul.20646 · Cited by 51 · see citing works

[8] Handles for solid-phase peptide synthesis

Songster, M. F., & Bárány, G. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)89047-7 · Cited by 50 · see citing works

Elastase, a marker for neutrophils in skin infiltrates

Lammers, A. M., van de Kerkhof, P. C. M., SCHALWIJK, J., & MIER, P. D. (1986) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1986.tb05715.x · Cited by 50 · see citing works

FRET‐based and other fluorescent proteinase probes

Hu, H., Gehrig, S. M., Reither, G., Subramanian, D., Mall, M. A., Plettenburg, O., & Schultz, C. (2014) · Biotechnology Journal · doi:10.1002/biot.201300201 · Cited by 49 · see citing works

Non-Peptide-Based Fluorogenic Small-Molecule Probe for Elastase

Sun, Q., Li, J., Liu, W.-N., Dong, Q., Yang, W., & Yang, G. (2013) · Analytical Chemistry · doi:10.1021/ac402097g · Cited by 49 · see citing works

Inhibition of Neutrophil Serine Proteinases by Suramin

Cadène, M., Duranton, J., North, A., Si‐Tahar, M., Chignard, M., & Bieth, J. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9950 · Cited by 49 · see citing works

Unconjugated Bilirubin Contributes to Early Inflammation and Edema after Intracerebral Hemorrhage

Loftspring, M. C., Johnson, H. L., Feng, R., Johnson, A. J., & Clark, J. F. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.203 · Cited by 48 · see citing works

Mapping the substrate binding site of human C1r and C1s with peptide thioesters. Development of new sensitive substrates.

McRae, B. J., Lin, T. Y., & Powers, J. C. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43280-2 · Cited by 48 · see citing works

Human neutrophil elastase alters human alpha-thrombin function: limited proteolysis near the gamma-cleavage site results in decreased fibrinogen clotting and platelet-stimulatory activity.

Brower, M. S., Walz, D. A., Garry, K., & Fenton, J. W. (1987) · PubMed · doi:10.1182/blood.v69.3.813.813 · Cited by 48 · see citing works

Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity.

Poe, M., Bennett, C. D., Biddison, W. E., Blake, J. T., Norton, G. P., Rodkey, J. A., SIGAL, N. H., Turner, R. V., Wu, J. K., & Zweerink, H. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37694-4 · Cited by 47 · see citing works

N-Acetylcysteine pretreatment of cardiac surgery patients influences plasma neutrophil elastase and neutrophil influx in bronchoalveolar lavage fluid

Backer, W. A. D., Amsel, B. J., Jorens, P. G., Bossaert, L. L., Hiemstra, P. S., van Noort, P., & van Overveld, F. J. (1996) · Intensive Care Medicine · doi:10.1007/bf02044114 · Cited by 47 · see citing works

Proteases released in organ culture by acute dermal inflammatory lesions produced in vivo in rabbit skin by sulfur mustard: Hydrolysis of synthetic peptide substrates for trypsin-like and chymotrypsin-like enzymes

樋口, 和., Kajiki, A., Nakamura, M., Harada, S., Pula, P. J., Scott, A. L., & Dannenberg, A. M. (1988) · Inflammation · doi:10.1007/bf00915768 · Cited by 47 · see citing works

Proteinase production by the parasitic cycle of the pathogenic fungus Coccidioides immitis

Resnick, S., Pappagianis, D., & McKerrow, J. H. (1987) · Infection and Immunity · doi:10.1128/iai.55.11.2807-2815.1987 · Cited by 47 · see citing works

Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin

Barrett, C. D., Moore, H. B., Banerjee, A. M., Silliman, C. C., Moore, E. E., & Yaffe, M. B. (2017) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001685 · Cited by 46 · see citing works

Specificity and reactivity of human leukocyte elastase, porcine pancreatic elastase, human granulocyte cathepsin G, and bovine pancreatic chymotrypsin with arylsulfonyl fluorides. Discovery of a new series of potent and specific irreversible elastase inhibitors.

Yoshimura, T., Barker, L. N., & Powers, J. C. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34637-4 · Cited by 46 · see citing works

Granulocyte elastase‐mediated proteolysis of alpha1‐antitrypsin in cystic fibrosis bronchopulmonary secretions

Cantin, A., Bilodeau, G., & Bégin, R. (1989) · Pediatric Pulmonology · doi:10.1002/ppul.1950070105 · Cited by 54 · see citing works

Polymorphonuclear Cells Isolated from Human Peripheral Blood Cleave Lipoprotein(a) and Apolipoprotein(a) at Multiple Interkringle Sites via the Enzyme Elastase

Edelstein, C., Italia, J. A., & Scanu, A. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11079 · Cited by 45 · see citing works

Identification of elastase in human eosinophils: Immunolocalization, isolation, and partial characterization

Lungarella, G., Menegazzi, R., Gardi, C., Spessotto, P., Santi, M. M. D., Bertoncin, P., Patriarca, P., Calzoni, P., & Zabucchi, G. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90060-a · Cited by 44 · see citing works

Biochemical methods for predicting metastatic ability of prostatic cancer utilizing the dunning R-3327 rat prostatic adenocarcinoma system as a model.

Lowe, F. C., & Isaacs, J. T. (1984) · PubMed · Cited by 44 · see citing works

Z-Isomers of lycopene and β-carotene exhibit greater skin-quality improving action than their all-E-isomers

Honda, M. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.135954 · Cited by 43 · see citing works

The synthesis and analytical use of a highly sensitive and convenient substrate of elastase

Bieth, J. G., Spiess, B., & Wermuth, C. G. (1974) · Biochemical Medicine · doi:10.1016/0006-2944(74)90134-3 · Cited by 732 · see citing works

Synthesis and Analytical Use of 3-Carboxypropionyl-alanyl-alanyl-valine-4-nitroanilide: A Specific Substrate for Human Leukocyte Elastase

Wenzel, H., Engelbrecht, S., REICH, H., MONDRY, W., & Tschesche, H. (1980) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1980.361.2.1413 · Cited by 39 · see citing works

N-acetyl-(L-Ala)3-p-nitroanilide as a new chromogenic substrate for elastase

Feinstein, G., Kupfer, A., & Sokolovsky, M. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)91508-8 · Cited by 62 · see citing works

An improved spectrophotometric assay for leucine aminopeptidase

Beattie, R., Guthrie, D. J. S., Elmore, D. T., Williams, C. H., & Walker, B. (1987) · Biochemical Journal · doi:10.1042/bj2420281 · Cited by 10 · see citing works

Water-soluble macromolecular fluorogenic substrates for assaying proteinases: Determination of pancreatic elastase activity

Anjuère, F., Monsigny, M. L. P., & Mayer, R. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90436-w · Cited by 8 · see citing works