The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states
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B6 mice are sensitive to TCDD-induced hepatotoxicity and induction of P450s.
“This observation exists despite B6 mice being sensitive to TCDD-induced hepatotoxicity and induction of P450s (D. W. Nebert & Gelboin, 1969).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as D. W. Nebert & Gelboin, 1969
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AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899 · see citing works
The aryl hydrocarbon receptor and the gut–brain axis
Barroso, A., Mahler, J. V., Fonseca-Castro, P. H., & Quintana, F. J. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00585-5 · Cited by 152 · see citing works
Denison, M. S., Wilkinson, C. F., & Okey, A. B. (1986) · Chemosphere · doi:10.1016/0045-6535(86)90452-2 · Cited by 70 · see citing works
Comparative studies of aryl hydrocarbon hydroxylase and the Ah receptor in nonmammalian species
Denison, M. S., Hamilton, J. W., & Wilkinson, C. F. (1985) · Comparative Biochemistry and Physiology Part C: Comparative Pharmacology · doi:10.1016/0742-8413(85)90063-5 · Cited by 35 · see citing works
Rodent Genetic Models of Ah Receptor Signaling
Wilson, R. H., & Bradfield, C. A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1955916 · Cited by 16 · see citing works
“This observation exists despite B6 mice being sensitive to TCDD-induced hepatotoxicity and induction of P450s (Nebert and Gelboin 1969).”
Background
- Authors
- Nebert, D. W., & Gelboin, H. V.
- Affiliations
- National Institutes of Health (US)
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 1969-10
- Volume
- 134
- Issue
- 1
- Pages
- 76-89
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W1994800122
- Cited by
- 420
- References
- 0
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 1 · 2013: 3 · 2012: 2
- FWCI
- 23.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- aryl hydrocarbon hydroxylase, enzyme induction, polycyclic hydrocarbons, 3-methylcholanthrene, phenobarbital, fetal development, genetic strain differences, adrenalectomy, hypophysectomy, 3T3 fibroblasts, liver, lung, kidney
- MeSH terms
- Adrenalectomy, Age Factors, Animals, Haplorhini, Benz(a)Anthracenes, Benzopyrenes, Cell Line, Cell Membrane, Chick Embryo, Digestive System, Enzyme Induction, Female, Fetus, Cricetinae, Hydrocarbons, Mixed Function Oxygenases, Hypophysectomy, Kidney, Liver, Lung, Male, Methylcholanthrene, Organ Specificity, Phenobarbital, Placenta, Pregnancy, Species Specificity, Tritium, Culture Techniques, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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