Isolated adrenal cortex cells: ACTH agonists, partial agonists, antagonists; cyclic AMP and corticosterone production
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The first attempts to design ACTH-like peptide antagonists produced peptides that retained the tetrabasic address region but lacked the HFRW message sequence, leading to the development of ACTH [11-24] as a potential receptor antagonist.
“The first attempts to do this resulted in peptides that retained the tetrabasic address region, but lacked the HFRW message sequence. This led to the development of ACTH [11–24] (49, 50) as a potential receptor antagonist.”
From ACTH Antagonists (2016) · cites this paper as [50]
Cites
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Practical Procedure for Estimation of Corticosterone or Hydrocortisone
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The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver
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Isolated adrenal cells: Steroidogenesis and cyclic AMP accumulation in response to ACTH
Beall, R. J., & Sayers, G. (1972) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(72)90116-6 · Cited by 178 · see citing works
Self-citationA molecular basis for drug action
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ACTH: a short introductory review
Schwyzer, R. (1977) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1977.tb41843.x · Cited by 394 · see citing works
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“This led to the development of ACTH [11–24] (49, 50) as a potential receptor antagonist.”
BackgroundEffects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cells
Szalay, K. S., de Wied, D., & Stark, E. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90261-6 · Cited by 17 · see citing works
- Authors
- Seelig, S., & Sayers, G.
- Affiliations
- Case Western Reserve University (US)
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 1973-01
- Volume
- 154
- Issue
- 1
- Pages
- 230-239
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2043475832
- Cited by
- 87
- References
- 19
- Citations by year
- 2025: 1 · 2018: 1 · 2016: 1
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- ACTH, adrenal cortex cells, cyclic AMP, corticosterone production, ACTH analogs, partial agonists, competitive antagonists, second messengers, receptor reserve, intrinsic activity, hormone potency
- MeSH terms
- Cyclic AMP, Adrenal Cortex Hormones, Adrenal Glands, Adrenocorticotropic Hormone, Amides, Animals, Carbon Isotopes, Cells, Corticosterone, Dose-Response Relationship, Drug, Lysine, Structure-Activity Relationship, Swine, In Vitro Techniques
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