Effects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cells
Abstract
The steroidogenic action of ACTH-(11-24) was studied on isolated zona glomerulosa and zona fasciculata cells dispersed by collagenase. ACTH-(11-24) stimulated the corticosterone production of zona fasciculata cells and the aldosterone production of zona glomerulosa cells; in addition, it potentiated the effects of ACTH-(1-39) on both cell systems. It is suggested that the ACTH molecule contains more active sites for steroidogenesis than usually acknowledged, as has been found for lipolysis and behavior.
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ACTH [11-24] stimulated steroidogenesis in dispersed zona glomerulosa and zona fasciculata cells.
“Szalay demonstrated that ACTH [11–24] stimulated steroidogenesis in dispersed zona glomerulosa and zona fasciculata cells (52)”
From ACTH Antagonists (2016) · cites this paper as [52]
Cites
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60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH
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Development of potent selective competitive-antagonists of the melanocortin type 2 receptor
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- Authors
- Szalay, K. S., de Wied, D., & Stark, E.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 32
- Issue
- 2
- Pages
- 259-262
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W2008390141
- Cited by
- 17
- References
- 19
- Citations by year
- 2016: 3 · 2014: 3
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Steroid Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- corticosteroid synthesis, adrenocortical cells, zona glomerulosa, zona fasciculata, aldosterone, corticosterone, ACTH 1-39
- MeSH terms
- Adrenal Cortex, Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Animals, Binding Sites, Corticosterone, Cosyntropin, Dose-Response Relationship, Drug, Male, Peptide Fragments, Rats, In Vitro Techniques
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