Inhibition of aminoacyl-sRNA binding to ribosomes by tetracycline
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Typical tetracyclines inhibit accommodation of aminoacyl-tRNA into the ribosomal A site and prevent addition of new amino acids to the growing polypeptide.
“More precisely, they inhibit accommodation of aminoacyl-tRNA (aa-tRNA) into the ribosomal A site (Fig. 1, reactions a and b) and, therefore, prevent the addition of new amino acids to the growing polypeptide (22, 25, 29, 48).”
From Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance (2003) · cites this paper as [48]
Cites
Mans, R. J., & Novelli, G. D. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90009-1 · Cited by 2,051 · see citing works
RNA Codewords and Protein Synthesis
Nirenberg, M. W., & Leder, P. (1964) · Science · doi:10.1126/science.145.3639.1399 · Cited by 1,418 · see citing works
Polypeptide synthesis in Escherichia coli
Gilbert, W. (1963) · Journal of Molecular Biology · doi:10.1016/s0022-2836(63)80051-0 · Cited by 369 · see citing works
Effect of Chloramphenicol on Protein Synthesis in Cell-free Preparations of Escherichia coli
Rendi, R., & Ochoa, S. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84512-x · Cited by 144 · see citing works
Mediation of Divalent Metal Ions in the Binding of Tetracycline to Macromolecules
Kohn, K. W. (1961) · Nature · doi:10.1038/1911156a0 · Cited by 104 · see citing works
Specific interaction of soluble RNA with polyribonucleic acid induced polysomes
Kaji, A., & Kaji, H. K. (1963) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(63)90279-1 · Cited by 79 · see citing works
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Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
Connell, S. R., Tracz, D. M., Nierhaus, K. H., & Taylor, D. E. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.12.3675-3681.2003 · Cited by 449 · see citing works
Tet(M)-promoted release of tetracycline from ribosomes is GTP dependent
Burdett, V (1996) · Journal of Bacteriology · doi:10.1128/jb.178.11.3246-3251.1996 · Cited by 121 · see citing works
Role of magnesium in the binding of tetracycline to Escherichia coli ribosomes
White, J. P., & Cantor, C. R. (1971) · Journal of Molecular Biology · doi:10.1016/0022-2836(71)90255-5 · Cited by 59 · see citing works
Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them
Chopra, I. (1985) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-70304-1_6 · Cited by 44 · see citing works
Connell, S. R., Trieber, C. A., Stelzl, U., Einfeldt, E., Taylor, D. E., & Nierhaus, K. H. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03115.x · Cited by 42 · see citing works
Binding Interaction between Tet(M) and the Ribosome: Requirements for Binding
Dantley, K. A., Dannelly, H. K., & Burdett, V. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.16.4089-4092.1998 · Cited by 37 · see citing works
Chimeras of bacterial translation factors Tet(O) and EF‐G
Thakor, N. S., Nechifor, R., Scott, P. G., Keelan, M., Taylor, D. E., & Wilson, K. S. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.023 · Cited by 4 · see citing works
- Authors
- Suarez, G., & Nathans, D.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1965-03
- Volume
- 18
- Issue
- 5-6
- Pages
- 743-750
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1978321893
- Cited by
- 169
- References
- 6
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2019: 3 · 2018: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- tetracycline, aminoacyl-tRNA binding, ribosome, polyphenylalanine synthesis, phenylalanyl-tRNA, poly(U), puromycin, chloramphenicol, antibiotic binding sites, protein synthesis inhibition
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