Role of magnesium in the binding of tetracycline to Escherichia coli ribosomes
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Divalent magnesium is crucial for binding of tetracycline to the ribosome.
“Divalent magnesium is known to be crucial for binding of Tc to the ribosome (White and Cantor 1971”
From The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit (2000) · cites this paper as White and Cantor 1971
In the primary (and Tet-1) site, several tetracycline-RNA interactions are mediated through a magnesium ion known to be important for tetracycline binding.
“(ii) In the primary (and Tet-1) site, several tetracycline-RNA interactions are mediated through a magnesium ion which is known to be important for tetracycline binding (4, 57).”
From Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance (2003) · cites this paper as [57]
Cites
Fluorescence Spectroscopy of Proteins
Stryer, L. (1968) · Science · doi:10.1126/science.162.3853.526 · Cited by 709 · see citing works
Antibiotic inhibitors of the bacterial ribosome
Weisblum, B., & DAVIES, J. E. (1968) · Bacteriological Reviews · doi:10.1128/mmbr.32.4_pt_2.493-528.1968 · Cited by 318 · see citing works
Inhibition of aminoacyl-sRNA binding to ribosomes by tetracycline
Suarez, G., & Nathans, D. (1965) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(65)90848-x · Cited by 169 · see citing works
Kohn, K. W. (1961) · Analytical Chemistry · doi:10.1021/ac60175a015 · Cited by 150 · see citing works
Structure and functior of Escherichia coli ribosomes
Traub, P., & Nomura, M. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90182-4 · Cited by 124 · see citing works
Control of heme synthesis by feedback inhibition
Karibian, D., & London, I. M. (1965) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(65)90747-3 · Cited by 105 · see citing works
Mediation of Divalent Metal Ions in the Binding of Tetracycline to Macromolecules
Kohn, K. W. (1961) · Nature · doi:10.1038/1911156a0 · Cited by 104 · see citing works
FRANKLIN, T. (1963) · Biochemical Journal · doi:10.1042/bj0870449 · Cited by 100 · see citing works
Binding of Specific Soluble Ribonucleic Acid to Ribosomes
Kaji, H. K., Suzuka, I., & Kaji, A. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96767-0 · Cited by 80 · see citing works
Day, L. E. (1966) · Journal of Bacteriology · doi:10.1128/jb.92.1.197-203.1966 · Cited by 51 · see citing works
Proton magnetic relaxation studies of the binding of manganese ions to Escherichia coli ribosomes
Sheard, B., Miall, S., PEACOCKE, A. R., et al. (1967) · Journal of Molecular Biology · doi:10.1016/s0022-2836(67)80088-3 · Cited by 33 · see citing works
Brown pigmentation (lipofuscinosis) of canine intestinal muscularis
Cordes, D. O., & Mosher, A. H. (1966) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700920120 · Cited by 33 · see citing works
Studies on the intracellular localization of tetracycline in bacteria
Connamacher, R. H., & Mandel, H. G. (1968) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(68)90235-9 · Cited by 30 · see citing works
On the specificity of the two ribosomal binding sites: Studies with tetracycline
Bodley, J. W., & Zieve, F. J. (1969) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(69)90587-7 · Cited by 24 · see citing works
Ashton, A. A. (1966) · Analytica Chimica Acta · doi:10.1016/s0003-2670(01)81724-4 · Cited by 9 · see citing works
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Brodersen, D. E., Clemons, W. M., Carter, A. P., Morgan-Warren, R. J., Wimberly, B. T., & Ramakrishnan, V. (2000) · Cell · doi:10.1016/s0092-8674(00)00216-6 · Cited by 950 · see citing works
“…crucial for binding of Tc to the Tetracycline Also Binds in the H27 Switch Region The second binding site of Tc is located in the body of ribosome (White and Cantor, 1971), and is found here in an identical position relative to Tc as in the structure the subunit, in close proximity to H44 and…”
BackgroundRibosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
Connell, S. R., Tracz, D. M., Nierhaus, K. H., & Taylor, D. E. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.12.3675-3681.2003 · Cited by 449 · see citing works
Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them
Chopra, I. (1985) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-70304-1_6 · Cited by 44 · see citing works
Epe, B., & Woolley, P. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01771.x · Cited by 44 · see citing works
- Authors
- White, J. P., & Cantor, C. R.
- Affiliations
- Columbia University (US)
- ORCID
- Cantor, Charles R.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1971-05
- Volume
- 58
- Issue
- 1
- Pages
- 397-400
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W1967253354
- Cited by
- 59
- References
- 15
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- tetracycline, ribosome binding, magnesium chelation, Escherichia coli ribosome, fluorescence enhancement, antibiotic binding
- MeSH terms
- Binding Sites, Chelating Agents, Escherichia coli, Fluorescence, Magnesium, Manganese, Ribosomes, Tetracycline
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