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Cited by 93

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Heparan sulphate proteoglycans are involved in the lipoprotein lipase-mediated enhancement of the cellular binding of very low density and low density lipoproteins

Mulder, Monique, Lombardi, Paola, Jansen, Hans, van Berkel, Theo J.C., Frants, Rune R., Havekes, Louis M.·1992·Biochemical and Biophysical Research Communications
DOI 10.1016/0006-291x(92)91664-c
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Abstract

We found that LPL enhances the binding to HepG2 cells and fibroblasts of both VLDL and apoE free LDL. In the presence of 1.7 micrograms/ml of purified bovine LPL, the binding of LDL and VLDL was up to 60 fold increased as compared to the control binding. In addition, LPL enhances the binding in LDL-receptor negative fibroblasts to the same extent as it does in normal fibroblasts. The presence of 10 mM of EGTA could not prevent the LPL-mediated enhancement of the binding of both LDL and VLDL to fibroblasts, indicating that the binding is calcium independent. Furthermore, up- and down regulation of the LDL receptor did not influence the binding of these lipoproteins in the presence of LPL. Strikingly, we found that the enhancing effect of LPL on the binding of LDL and VLDL to HepG2 cells could be abolished by preincubation of the cells with heparinase, suggesting that heparan sulphate proteoglycans are involved in the LPL-mediated stimulation. We hypothesize that the enhancement of the cellular binding of LDL and VLDL in the presence of LPL is caused by an LPL-bridging between proteoglycans present on the plasma membrane and the lipoproteins, and that the LDL receptor and LRP are not involved.

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Crossref · 10.1016/0006-291x(92)91664-c

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2 of 2 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 20

  1. Herz, 1988, EMBO J, 7, 4119, 10.1002/j.1460-2075.1988.tb03306.x · DOI
  2. Beisiegel, 1989, Nature (London), 341, 162, 10.1038/341162a0 · DOI
  3. Kowal, 1989, 86, 5810
  4. Strickland, 1990, J. Biol. Chem, 265, 17401, 10.1016/S0021-9258(18)38172-9 · DOI · Paper page
  5. Kita, 1982, 79, 3623
  6. Mulder, 1990, Biochim. Biophys. Acta, 1081, 308, 10.1016/0005-2760(91)90287-R · DOI
  7. Windler, 1980, J. Biol. Chem, 255, 10464, 10.1016/S0021-9258(19)70487-6 · DOI
  8. Eisenberg, 1988, Arteriosclerosis, 8, 480, 10.1161/01.ATV.8.5.480 · DOI
  9. Harkes, 1989, Eur. J. Biochem, 180, 241, 10.1111/j.1432-1033.1989.tb14639.x · DOI
  10. Van Dijk, 1991, Biochem. J, 279, 863, 10.1042/bj2790863 · DOI
  11. Beisiegel, 1991, 88, 8342
  12. Villeli, 1991, Med. Sci. Res, 19, 111
  13. Lowry, 1951, J. Biol. Chem, 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
  14. Bilheimer, 1972, Biochim. Biophys. Acta, 260, 212, 10.1016/0005-2760(72)90034-3 · DOI
  15. Tajima, 1984, J. Biol. Chem, 96, 1753
  16. Lombardi, 1990, Biochim. Biophys. Acta, 1044, 127, 10.1016/0005-2760(90)90227-O · DOI
  17. Havekes, 1986, Biochim. Biophys. Acta, 875, 236, 10.1016/0005-2760(86)90173-6 · DOI
  18. Hamilton, 1990, J. Lipid Res, 31, 1589, 10.1016/S0022-2275(20)42343-0 · DOI · Paper page
  19. Brown, 1991, Current Opinion in Lipidology, 2, 65, 10.1097/00041433-199104000-00002 · DOI
  20. Cisar, 1989, J. Biol. Chem, 264, 1767, 10.1016/S0021-9258(18)94253-5 · DOI

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Metadata

Authors
Mulder, M., Lombardi, P., Jansen, H., van Berkel, T. J. C., Frants, R. R., & Havekes, L. M.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1992-06
Volume
185
Issue
2
Pages
582-587
ISSN
0006-291X
DOI
10.1016/0006-291x(92)91664-c
Cited by
93
References
2
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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