Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

Brown, M S; Goldstein, J L

doi:10.1172/jci111044

Cited by 545Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

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Brown, M S, Goldstein, J L·1983·Journal of Clinical Investigation

DOI 10.1172/jci111044PMC PMC1129238

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Abstract

A decade of intense investigation has established a central role for lipoprotein receptors in regulating plasma cholesterol traffic. These receptors bind cholesterol-carrying lipoproteins and transport them into cells by receptor-mediated endocytosis. The receptor for low density lipoprotein (LDL) was the first discovered; it has been purified and its structure characterized. The LDL receptor was described in cultured human fibroblasts; identical receptors are now known to function in liver as well as in extrahepatic tissues. Operationally, the LDL/LDL receptor system can be considered the primary transport mechanism for endogenous cholesterol. Dietary cholesterol, on the other hand, is transported from the intestine in chylomicron remnants, which enter hepatocytes via distinct chylomicron remnant receptors. The chylomicron remnant/remnant receptor system is to exogenous cholesterol transport as the LDL/LDL receptor system is to endogenous cholesterol transport. In this article, we review recent developments in this rapidly advancing field.

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LDL biology is mostly relevant for peripheral diseases.
“While LDL biology is mostly relevant for peripheral diseases32,54,55”
From Decreased lipidated ApoE‐receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes (2025) · cites this paper as [54]
The paper emphasizes hepatic LDL receptors rather than presenting LDL biology as mostly peripheral. In “Control Signals for Plasma Cholesterol Traffic” (pp. 1–2), it says that more than half of LDL receptors are in the liver and that changes in hepatic receptor activity alter plasma LDL levels. It also discusses extrahepatic tissues and atherosclerosis, but does not characterize LDL biology as mostly relevant to peripheral diseases. (LLM, conf=0.75)
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Authors: Brown, M. S., & Goldstein, J. L.
ORCID: Goldstein, J L
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1983-09-01
Volume: 72
Issue: 3
Pages: 743-747
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci111044
PMC: PMC1129238
OpenAlex: W2137716547
Cited by: 545
References: 48
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 13
FWCI: 66.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (HL20948)
Topics: Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: lipoprotein receptors, liver, LDL receptor, receptor-mediated endocytosis, chylomicron remnants, dietary cholesterol, hepatocytes
MeSH terms: Animals, Apolipoproteins, Apolipoproteins E, Apoproteins, Binding, Competitive, Cholesterol, Cyclohexanones, Dogs, Guinea Pigs, Cricetinae, Humans, Hyperlipoproteinemia Type II, Liver, Macaca mulatta, Molecular Weight, Rabbits, Receptors, Cell Surface, Receptors, LDL, Receptors, Lipoprotein, Rats

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Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

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