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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

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The Prediction of Human Pharmacokinetic Parameters from Preclinical and in Vitro Metabolism Data

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Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

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Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development

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A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

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Prediction of Human Pharmacokinetics from Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

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Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs

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Identification of drugs that interact with herbs in drug development

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Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

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Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation

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Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades

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Challenges and opportunities with modelling and simulation in drug discovery and drug development

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Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling

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An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery

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The Use of Human Hepatocytes to Select Compounds Based on Their Expected Hepatic Extraction Ratios in Humans

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Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance

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Prediction of Human Pharmacokinetic Profile in Animal Scale up Based on Normalizing Time Course Profiles

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Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling

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Prediction of Clearance, Volume of Distribution and Half-Life by Allometric Scaling and by Use of Plasma Concentrations Predicted from Pharmacokinetic Constants: A Comparative Study

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Interspecies Scaling: Predicting Volumes, Mean Residence Time and Elimination Half-life.* Some Suggestions

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Fungal-selective resorcylate aminopyrazole Hsp90 inhibitors: optimization of whole-cell anticryptococcal activity and insights into the structural origins of cryptococcal selectivity

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Liver organoids: Current advances and future applications for hepatology

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